Conclusion
It is important to take into account the heterogeneity of flows when estimating PS m when the cell uptake rate is above 1 mlg−1 min−1. At lower PS m 's the need is not so great when PSc is about 1 mlg−1 min−1 because of counteropposing influences of the various parameters on the shapes of the counteropposing influences of the various parameters on the shapes of the curves. It is not known whether this generally applies when PSc is much higher or much lower than 1 mlg−1 min−1.
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Bassingthwaighte, J.B., Levin, M. Analysis of coronary outflow dilution curves for the estimation of cellular uptake rates in the presence of heterogeneous regional flows. Basic Res Cardiol 76, 404–410 (1981). https://doi.org/10.1007/BF01908332
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DOI: https://doi.org/10.1007/BF01908332