Summary
Using a special Millar ultraminiature catheter pressure transducer, right ventricular functional parameters were measured in anesthetized, closed-chest rats under control conditions, during acute pulmonary hypertension and after induction of right ventricular hypertrophy. Acute i.v. infusion of noradrenaline and a brief period of hypoxia in female Sprague-Dawley rats elicited a marked increase in right ventricular systolic pressure (RVSP) and in the maximal rate of rise in right ventricular pressure (RV dp/dtmax). After 3 and 16 days of daily administrations of triodothyronine in female Sprague-Dawley rats, all right ventricular hemodynamic parameters were enhanced along with the increase in left ventricular function. The right and left ventricles were hypertrophicd, and cardiac output was increased. After 40 and 45 days subsequent to bilateral thorax irradiation of male Brown-Norway rats, RVSP and RV dp/dtmax were increased, the right ventricle was hypertrophied, while the left ventricle did not exhibit appreciable hemodynamic or morphologic alterations. Cardiac output was depressed. Thus, these two experimental models differ considerably as to the mechanism and time course of the development of right ventricular hypertrophy as well as to the participation of the left ventricle and the involvement of volume overload.
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Abraham AS, Kay JM, Cole RB, Pincock AC (1971) Haemodynamic and pathological study of the effect of chronic hypoxia and subsequent recovery of the heart and pulmonary vasculature of the rat. Cardiovasc Res 5:95–102
Bak G, Strubelt O (1975) Seasonal variations of cardiac output in rats. Experientia 31/11:1304–1306
Büttner D, Plonait H (1980) Langfristige Messungen der maximalen, mittleren und Ruhefrequenz an Laborratten mittels implantierbarer Telemetriesender. Zbl Vet Med A 27:269–278
Chesney CF, Allen JR, Hsu IC (1974) Right ventricular hypertrophy in monocrotaline pyrolle treated rats. Exp Mol Pathol 20:257–268
Dowell RT, Cutilletta AF, Sodt PC (1975) Functional evaluation of the rat heart in situ. J Appl Physiol 39:1043–1047
Fishman AP (1976) Hypoxia on the pulmonary circulation. How and where it acts. Circ Res 38:221–231
Fleck A, Munroe HN (1962) The precision of ultraviolet absorption measurements in the Schmidt-Thannhauser procedure for nucleic acid estimation. Biochim Biophys Acta 55:571–583
Gerdes AM, Moore JA, Bishop SP (1985) Failure of propranolol to prevent chronic hyperthyroid induced cardiac hypertrophy and multifocal cellular necrosis in the rat. Can J Cardiol 1:340–345
Ghodsi F, Will JA (1981) Changes in pulmonary structure and function induced by monocrotaline intoxication. Am J Physiol 240:H149-H155
Gross NJ (1981) The pathogenesis of radiation-induced lung damage. Lung 159:115–125
Hayes BE, Will JA (1978) Pulmonary artery catheterization in the rat. Am J Physiol 235:H452-H454
Heath D, Castillo Y, Arias-Stclla J, Harris P (1969) The small pulmonary arteries of the Ilama and other domestic animals native to high altitudes. Cardiovasc Res 3:75–78
Herget J, Palaček F (1972) Pulmonary arterial blood pressure in closed chest rats changes after catecholamines, histamine and serotonin. Arch Int Pharacodyn 198:107–117
Lin Y-C, Dawson CA, Nadel ER, Horvath SM (1970) Reliability of cardiac output mcasured by thermodilution method in small animals. Comp Biochem Physiol 34:245–250
Maisin JR (1970) The ultrastructure of the lung of mice exposed to a supra-lethal dose of ionizing radiation on the thorax. Radiation Res 44:545–564
Mannesmann G, Müller B (1980) Measurement of cardiac output by the thermodilution method in rats: The effect of different volumes and temperatures of the indicator solution on cardiac output measurements and on cardiodynamics and hemodynamics of the anesthetized rat. J Pharmacol Methods 4:11–18
Meidell RS, Sen A, Henderson SA, Slahetka MF, Chien KR (1986) α1-Adrenergic stimulation of rat myocardial cells increases protein synthesis. Am J Physiol 251:H1076-H1084
Meyrick B, Gamble W, Reid L (1980) Development of crotalaria pulmonary hypertension: hemodynamic and structural study. Am J Physiol 239:H692-H702
Motley HL, Cournand A, Werko L, Himmelstein A, Dresdale D (1947) The influence of short periods of induced acute anoxia upon pulmonary artery pressures in man. Am J Physiol 150:315–320
Pfeffer MA, Pfeffer JM, Fishbein MC, Fletcher PJ, Spadaro J, Kloner RA, Braunwald E (1979) Myocardial infarct size and ventricular function in rats. Circ Res 44:503–512
Raab W (1943) The pathogenic significance of adrenaline and related substances in the heart muscle. Exp Med Surg 1:188–225
Rabinovitch M, Gamble W, Nadas AS, Miettinen OS, Reid L (1979) Rat pulmonary circulation after chronic hypoxia: hemodynamic and structural features. Am J Physiol 236:H818-H827
Simpson P (1985) Stimulation of hypertrophy of cultured neonatal rat heart cells through an α1-adrenergic receptor and induction of heating through an α1- and β1-adrenergic receptor interaction. Evidence for independent regulation of growth and beating. Circ Res 56:884–894
Slauson DO, Hahn FF, Chiffelle TL (1977) The pulmonary vascular pathology of experimental radiation pneumonitis. Am J Pathol 88:635–648
Steele WJ, Okamura N, Busch H (1964) Prevention of loss of RNA, DNA and protein into lipid solvents. Biochim Biophys Acta 87:490–492
Stinger RB, Iacopino VJ, Alter I, Fitzpatrick TM, Rose JC, Kot PA (1981) Catheterization of the pulmonary artery in the closed chest rat. J Appl Physiol: Respirat Environ Exercise Physiol 51:1047–1050
Van Liere EJ, Sizemore DA, Hunnell J (1969) Size of cardiac ventricles in experimental hyporthyroidism in the rat. Proc Soc Exp Biol Med 132:663–665
Vetterlein F, Sammler J, Dal Ri H, Schmidt G (1984) Method for measurement of heart rate in awake, noninstrumented small mammals. Am J Physiol 247:H1010-H1012
Voelkel NF, McMurty IF, Reeves JT (1980) Chronic propranolol treatment blunts right ventricular hypertrophy in rats at high altitude. J Appl Physiol: Respirat Environ Exercise Physiol 48:473–478
Von Euler US, Liljestrand G (1947) Observation on the pulmonary arterial blood pressure in the cat. Acta Physiol Scand 12:301–320
Zimmer H-G (1983) Measurement of left ventricular hemodynamic parameters in closed-chest rats under control and various pathophysiologic conditions. Basic Res Cardiol 78:77–84
Zimmer H-G (1983) Normalization of depressed heart function in rats by ribose. Science 220:81–82
Zimmer H-G (1984) Correlation between haemodynamic and metabolic changes in three models of experimental cardiac hypertrophy. Eur Heart J 5 (Suppl F):171–179
Zimmer H-G, Gerlach E (1980) Early metabolic alterations during the development of experimentally induced cardiac hypertrophy. Arzneim Forsch/Drug Res 30(II) 11a:2001–2007
Zimmer H-G, Ibel H (1979) Effects of isoproterenol and dopamine on the myocardial hexose monophosphate shunt. Expericntia 35:510–511
Zimmer H-G, Ibel H (1983) Effects of ribose on cardiac metabolism and function in isoproterenoltreated rats. Am Physiol 245:H880-H886
Zimmer H-G, Pfeffer H (1986) Metabolic aspects of the development of experimental cardiac hypertrophy. Basic Res Cardiol 81 (Suppl 1):127–137
Zimmer H-G, Zierhut W, Marschner G (1987) Combination of ribose with calcium antagonist and β-blocker treatment in closed-chest rats. J Mol Cell Cardiol 19:635–639
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Zimmer, H.G., Zierhut, W., Seesko, R.C. et al. Right heart catheterization in rats with pulmonary hypertension and right ventricular hypertrophy. Basic Res Cardiol 83, 48–57 (1988). https://doi.org/10.1007/BF01907104
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DOI: https://doi.org/10.1007/BF01907104