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Technique for precise, graded arterial stenosis and occlusion

Eine Technik für die exkte, abgestafte Einengung von Arterien

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Summary

A variable mechanical occluder has been designed which, by means of a micrometer, permits graded stenosis of an artery in precise, reproducible increments. The design also allows transient, complete occlusion of the artery to establish zero flow without alteration of the level of stenosis established prior to the zeroing procedure. The device has been used to partially block the reactive hyperemic response following coronary and femoral artery occlusion, but is readily adaptable to vessels of other size by means of an interchangeable occluder subassembly.

Zusammenfassung

Es wurde eine mechanische Vorrichtung entworfen, die es erlaubt, mittels eines Mikrometers eine abgestufte, exakt reproduzierbare Einengung einer Arterie vorzunehmen. Die Apparatur wurde bisher an Koronararterien und Femoralarterien erprobt. Mittels eines austauschbaren Okkluderzusatzes ist sie jedoch leicht auch an Gefäße anderer Größe anzupassen.

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Author notes

  1. M. J. Hosko

    Present address: Department of Pharmacology, Medical College of Wisconsin, 561 North 15 Street, 53233, Milwaukee, Wisconsin, (USA)

Authors and Affiliations

  1. Department of Pharmacology, Medical College of Wisconsin, 561 North 15 Street, 53233, Milwaukee, Wisconsin, (USA)

    G. J. Gross (Recipient of a Pharmaceutical Manufacturers Association Career Development Award) & D. C. Warltier (Fellow of the National Science Foundation)

Authors
  1. M. J. Hosko
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  2. G. J. Gross
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  3. D. C. Warltier
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Additional information

With 6 figures and 2 tables

This study was supported by USPHS Grant HL 08311.

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Hosko, M.J., Gross, G.J. & Warltier, D.C. Technique for precise, graded arterial stenosis and occlusion. Basic Res Cardiol 72, 651–659 (1977). https://doi.org/10.1007/BF01907045

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  • DOI: https://doi.org/10.1007/BF01907045

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