Skip to main content
SpringerLink
Log in

Transformation of morphological, functional and metabolic properties of fast-twitch muscle as induced by long-term electrical stimulation

Transformation morphologischer, funktioneller und metabolischer Eigenschaften schneller Muskeln durch langdauernde elektrische Reizung

  • Original Contributions
  • Published:
Basic Research in Cardiology Aims and scope Submit manuscript

Summary

Transformation of structural, functional, metabolic and molecular characteristics is induced by stimulating fast-twitch muscles with the frequency pattern of a motoneuron normally innervating a slow-twitch muscle. These changes correspond to a transition of a “fast-white” into a “slow-red” muscle. Intermittent stimulation (8 h/d) does not affect the system but causes alterations of the sarcoplasmic reticulum which lead to changes in time to peak and half relaxation time. Continuous stimulation (24 h/d) induces a transformation of the muscle also at the level of the myosin system.

Zusammenfassung

Dauerstimulation schneller Muskeln mit dem Frequenzmuster langsamer Motoneurone induziert in schnellen Kaninchenmuskeln eine Transformation morphologischer, funktioneller, metabolischer und molekularer Merkmale. Diese Veränderungen entsprechen der Umwandlung eines “schnellen/weißen” in einen “langsamen/roten” Muskel. Intermittierende (8 Std/Tag) Stimulation bewirkt keine Umwandlung des Myosins, induziert aber eine solche des sarkoplasmatischen Retikulums. Kontinuierliche (24 Std/Tag) Stimulation bewirkt eine Transformation des Muskels, die auch eine Umwandlung des Myosins einschließt.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. Salmons, S., G. Vrbová: The Influence of Activity on Some Contractile Characteristics of Mammalian Fast and Slow Muscles. J. Physiol. (Lond.)201, 535 (1969).

    Google Scholar 

  2. Pette, D., H. W. Staudte, G. Vrbová: Physiological and Biochemical Changes Induced by Long-Term Stimulation of Fast Muscle. Naturwissensch.59, 469 (1972).

    Article  Google Scholar 

  3. Pette, D., M. E. Smith, H. W. Staudte, G. Vrbová: Effects of Long-Term Electrical Stimulation on Some Contractile and Metabolic Characteristics of Fast Rabbit Muscles. Pflügers Arch.338, 257 (1973).

    Article  Google Scholar 

  4. Peckham, P. H., J. T. Mortimer, J. P. van der Meulen: Physiologic and Metabolic Changes in White Muscle of Cat Following Induced Exercise. Brain Res.50, 424 (1973).

    Article  PubMed  Google Scholar 

  5. Cotter, M., O. Hudlická, D. Pette, H. W. Staudte, G. Vrobá: Changes of Capillary Density and Enzyme Pattern in Fast Rabbit Muscles During Long-Term Stimulation. J. Physiol. (Lond.)230, 34 P (1973).

    Google Scholar 

  6. Brown, M. D., M. Cotter, O. Hudlická, M. E. Smith, G. Vrbová: The Effect of Long-Term Stimulation of Fast Muscles on Their Ability to Withstand Fatigue. J. Physiol. (Lond.)238, 47 (1973).

    Google Scholar 

  7. Sréter, F. A., J. Gergely, S. Salmons, F. Romanul: Synthesis by Fast Muscle of Myosin Light Chains Characteristic of Slow Muscle in Response to Long-Term Stimulation. Nature New Biol.241, 17 (1973).

    PubMed  Google Scholar 

  8. Sréter, F. A., F. C. A. Romanul, S. Salmons, J. Gergely: The Effect of a Changed Pattern of Activity on Some Biochemical Characteristics of Muscle. In: “Exploratory Concepts in Muscular Distrophy II” (A. T. Milhorat ed.). Int. Congr. Ser.333, 338, Excerpta Medica (Amsterdam 1974).

    Google Scholar 

  9. Romanul, F. C. A., F. A. Sréter, S. Salmons, J. Gergely: The effect of a Changed Pattern of Activity on Histochemical Characteristics of Muscle Fibers. In “Exploratory Concepts in Muscular Dystrophy II” (A. D. Milhorat ed.), Int. Congr. Ser.333, 344, Excerpta Medical (Amsterdam 1974).

    Google Scholar 

  10. Ramirez, B. U., D. Pette: Effects of Long-Term Electrical Stimulation on Sarcoplasmic Reticulum of Fast Rabbit Muscle. FEBS Lett.49, 188 (1974).

    Article  PubMed  Google Scholar 

  11. Pette, D., B. U. Ramirez, W. Müller, R. Simon, R. Hildebrand: Influence of Intermittent Long-Term Stimulation on Contractile, Histochemical and Metabolic Properties of Fibre Populations in Fast and Slow Rabbit Muscles. Pflügers Arch.361, 1 (1975).

    Article  Google Scholar 

  12. Pette, D., W. Müller, E. Leisner, G. Vrbová: Time Dependent Effects on Contractile Properties, Fibre Population, Myosin Light Chains and Enzymes of Energy Metabolism in Intermittently and Continuously Stimulated Fast Twitch Muscles of the Rabbit. Pflügers Arch.364, 103 (1976).

    Article  Google Scholar 

  13. Brown, M. D., M. A. Cotter, O. Hudlická, G. Vrbová: The Effects of Different Patterns of Muscle Activity on Capillary Density, Mechanical Properties and Structure of Slow and Fast Rabbit Muscles. Pflügers Arch.361, 241 (1976).

    Article  Google Scholar 

  14. Salmons, S., F. A. Sréter: Significance of Impulse Activity in the Transformation of Skeletal Muscle Type. Nature263, 30 (1976).

    PubMed  Google Scholar 

Download references

Author information

Author notes

  1. D. Pette

    Present address: Fachbereiche Biologie, Universität Konstanz, Postfach 77 33, D-7750, Konstanz

Authors and Affiliations

  1. Fachbereiche Biologie, Universität Konstanz, Postfach 77 33, D-7750, Konstanz

    C. Heilmann

Authors
  1. D. Pette
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. Heilmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

With 3 figures

This study was supported by the Deutsche Forschungsgemeinschaft, Sonderforschungsbereich 138 “Biologische Grenzflächen und Spezifität”.C. Heilmann ist postdoctoral fellow of the Deutsche Forschungsgemeinschaft.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Pette, D., Heilmann, C. Transformation of morphological, functional and metabolic properties of fast-twitch muscle as induced by long-term electrical stimulation. Basic Res Cardiol 72, 247–253 (1977). https://doi.org/10.1007/BF01906369

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01906369

Keywords

Search

Navigation