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Preliminary studies of the metabolism of 2-guanidinomethyl-1:4-benzodioxan sulphate (guanoxan)

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El sulfato de 2-guanidinometil-1:4-benzo-dioxano (guanidino14C) se sintetizó a partir del 2-aminometil-1: 4-benzodioxano y el sulfato de S-metiltiouronio (uronio14C). Un 52–53% de la dosis radioactiva administrada a los perros se recuperó en la orina en la forma de los siguientes compuestos radioactives:arginina, creatina, acido guanidino acético, creatinina, urea, 2-guanidinometil-1: 4-benzodioxano y un derivado hidroxilado (fenólico) del anterior. Se sintetizó tambien el sulfato de 2-guanidinometil-7-hidroxi-1:4-benzodioxano.

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  1. Chemical Research Department, Pfizer Ltd., Sandwich, Kent, England

    A. Cañas-Rodriguez

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  1. A. Cañas-Rodriguez
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Cañas-Rodriguez, A. Preliminary studies of the metabolism of 2-guanidinomethyl-1:4-benzodioxan sulphate (guanoxan). Experientia 22, 472–473 (1966). https://doi.org/10.1007/BF01900994

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  • DOI: https://doi.org/10.1007/BF01900994

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