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Action of β- receptor blocking sympatholytics and of catecholamine depleting agents on CaCl2-induced arrhythmias in rats

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Zusammenfassung

Nach mehrtägiger Vorbehandlung zeigt das amindepletierende DCI-Derivat I-06 (noch 24 h nach letzter Verabreichung) einen starken antifibrilla-torischen Effekt gegen CaCl2-Ventrikelflimmern. Das nicht amindepletierende Propranolol ist zu diesem Zeitpunkt unwirksam. Eine Schutzwirkung verursachen auch Prenylamin, Guanethidin, α-Methyldopa und in geringerem Masse auch Reserpin. Bretylium bleibt ohne Einfluss. Die eventuelle Bedeutung der amindepletierenden Wirkung im Mechanismus der langdauernden antiarrhythmischen Wirkung wird diskutiert.

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Authors and Affiliations

  1. Department of Pharmacology of the University Medical Schools of Pécs, Hungary

    J. Papp, W. Förster, L. Szekeres & V. Rösler

  2. Magdeburg, DDR

    J. Papp, W. Förster, L. Szekeres & V. Rösler

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  1. J. Papp
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  2. W. Förster
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  3. L. Szekeres
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  4. V. Rösler
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Papp, J., Förster, W., Szekeres, L. et al. Action of β- receptor blocking sympatholytics and of catecholamine depleting agents on CaCl2-induced arrhythmias in rats. Experientia 22, 524–525 (1966). https://doi.org/10.1007/BF01898669

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  • DOI: https://doi.org/10.1007/BF01898669

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