Summary
The expression of H-Y antigen was examined in 30 patients with abnormal gonadal differentiation. Four patients with XX true hermaphroditism and 8 with XX male syndrome were all H-Y positive, in spite of the absence of cells bearing Y chromosome in the body. Of the 7 patients studied with XY gonadal dysgenesis, 6 paitents were H-Y positive and one was negative. The reduced antigen titer as compared to normal males was observed in one of the H-Y positive patients. Clinical and cytogenetic studies in the total 30 patients adding 4 of mixed gonadal dysgenesis and 3 of male pseudohermaphroditism, could not establish strict correlations among sex chromosome complement, H-Y antigen, and gonadal type of patients. However, a distinct association was recognized; when testicular structure was seen in the gonad, the H-Y antigen of the patient was always positive regardless of sex chromosome complement. In this study, our modified method and technical problems on the H-Y antigen examination are described, and genetic mechanisms for the regulation of H-Y antigen expression are discussed.
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Yamada, K., Isurugi, K. H-Y antigen studies in thirty patients with abnormal gonadal differentiation: Correlations among sex chromosome complement, H-Y antigen, and gonadal type. Jap J Human Genet 26, 227–235 (1981). https://doi.org/10.1007/BF01896134
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DOI: https://doi.org/10.1007/BF01896134
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