Summary
This report is about a 23-year-old man who required hemodialysis in connection with an acute renal failure resulting from uric acid nephropathy without hyperuricemia. After recovering renal function he showed extreme hypouricemia (0,1–0,3 mg/dl) and elevated uric acid clearance (100–300 ml/min). The fractional excretion of uric acid (Cua/Cer) could be suppressed by oral pyrazinamide and enhanced by probenecid. As no other renal tubular or metabolic abnormalities were detected, it is suggested that a markedly increased renal tubular urate secretion was responsible for the hypouricemia and also for the rare side-effect of an uric acid nephropathy in this patient.
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Abbreviations
- PZA:
-
pyrazinamide
- GFR:
-
glomerular filtration rate
- SUA :
-
serum uric acid
- UVUA :
-
urinary excretion of uric acid
- CUA :
-
uric acid clearance
- CCR :
-
creatinine clearance
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Erley, C.M.M., Hirschberg, R.R., Hoefer, W. et al. Acute renal failure due to uric acid nephropathy in a patient with renal hypouricemia. Klin Wochenschr 67, 308–312 (1989). https://doi.org/10.1007/BF01892900
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DOI: https://doi.org/10.1007/BF01892900