Zusammenfassung
Es wird über erste klinische Erfahrungen in der Behandlung der Pachydermia laryngis mit dem Testosteronantagonisten Cyproteronazetat an elf Patienten beiderlei Geschlechts berichtet. Diese neuartige Therapie führte in vier Fällen zu vollständiger Heilung, bei sechs Patienten zu wesentlicher Besserung und blieb in einem Fall erfolglos! Hormonbestimmungen deckten Störungen im Androgen/Östrogen-Gleichgewicht auf. Die Bedeutung endokriner Faktoren für die Pathogenese und die Therapie von Epithelveränderungen im Larynx als einem sekundären Geschlechtsmerkmal wird diskutiert.
Summary
First clinical experiences with the anti-androgenic drug cyproteroneacetate in treatment of pachydermia laryngis are reported in eleven male and female patients. This endocrine therapy led to complete healing in four and to marked improvement in six patients. One did not respond. Evaluation of the endocrine state of these patients showed imbalance in the androgen/estrogen equilibrium. As the larynx constitutes a secondary sex characteristic and an endocrine target organ, the significance of endocrine factors for pathogenesis and therapy of epithelial changes on the vocal cords is discussed.
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Hussl, B., Loewit, K., Richter, E. et al. First clinical experiences with hormone-therapy of pachydermia laryngis. Arch Otorhinolaryngol 221, 221–225 (1978). https://doi.org/10.1007/BF01886299
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DOI: https://doi.org/10.1007/BF01886299