Summary
Hypervariable ‘minisatellite’ regions which are dispersed in the human genome show restriction fragment length polymorphisms (RFLPs) due to allelic differences in the number of tandem repeats containing the core sequence. Southern blot hybridization using minisatellite core probes produces various band patterns, which are completely individual-specific and of which few fragments are shared between two randomly selected individuals. If the band patterns are identical between twins, they must be monozygotic. We report here the use of minisatellite core probe for zygosity determination in five Japanese twin pairs and in a set of triplets.
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Motomura, K., Tateishi, H., Nishisho, I. et al. The zygosity determination of Japanese twins using a minisatellite core probe. Jap J Human Genet 32, 9–14 (1987). https://doi.org/10.1007/BF01876522
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DOI: https://doi.org/10.1007/BF01876522