Summary
Urine amylase activity was measured in 142 boys and girls including unrelated twin individuals, aged 12–16 years. Statistical analysis revealed different distribution in the group with positive protein or blood reaction. Log distribution in a homogeneous sample population was unimodal with a skewness (\(\sqrt {\beta _1 } \)=−0.6493) and kurtosis (β2=3.4917). Intraclass correlation coefficients of overall activities were 0.6696 (p<0.001) in MZ twins (50 pairs) and −0.1299(n.s.) in DZ twins (22 pairs). In the rate of isozyme activity, correlation was nonsignificant.
Plasma of 36 twin pairs aged 13 to 15 years were similarly examined. Log distribution of overall activity was unimodal with a skewness (\(\sqrt {\beta _1 } \)=0.2321) and kurtosis (β2=0.7416). Intraclass correlation coefficients of overall activity were 0.8413 (p<0.001) in MZ twins (29 pairs) and 0.3689 (n.s.) in DZ twins (7 pairs). Intraclass correlation of plasma isozyme activity rate was 0.5490 (p<0.01) in MZ twins, but not significant in DZ twins.
Parent-offspring correlation of plasma overall amylase activity was 0.2848 (p<0.05) and its mid-parent-offspring correlation was 0.3727 (p<0.05). Heritability was 0.5298 from parent-offspring regression and 0.4408 from mid-parent-offspring regression.
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Park, K.S. Heritability of urine and plasma amylase activity. Jap J Human Genet 22, 79–88 (1977). https://doi.org/10.1007/BF01874272
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DOI: https://doi.org/10.1007/BF01874272
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