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Theory of lipid monolayer and bilayer phase transitions: Effect of headgroup interactions

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Summary

Headgroup and soft core interactions are added to a lipid monolayer-bilayer model and the surface pressure-area phase diagrams are calculated. The results show that quite small headgroup interactions can have biologically significant effects on the transition temperature and the phase diagram. In particular, the difference in transition temperatures of lecithins and phosphatidyl ethanolamines is easy to reproduce in the model. The phosphatidic acid systems seem to require weak transient hydrogen bonding which is also conjectured to play a role in most of the lipid systems. By a simple surface free energy argument it is shown that monolayers under a surface pressure of 50 dynes/cm should behave as bilayers, in agreement with experiment. Although the headgroup interactions are biologically very significant, in fundamental studies of the main phase transition in lipids they are secondary in importance to the hydrocarbon chain interactions (including the excluded volume interaction, the rotational isomerism, and the attractive van der Waals interaction).

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References

  1. Alexander, A.E. 1942. The role of hydrogen bonds in condensed monolayers.Proc. Roy. Soc. London A 179:470

    Google Scholar 

  2. Cater, B.R., Chapman, D., Hawes, S.M., Saville, J. 1974. Lipid phase transitions and drug interactions.Biochim. Biophys. Acta 363:54

    PubMed  Google Scholar 

  3. Coulson, C.A. 1961. Valence. Oxford University Press, p. 353

  4. Devaux, P., McConnell, H.M. 1972. Lateral diffusion in spin-labeled phosphatidylcholine multilayers.J. Am. Chem. Soc. 94:4475

    PubMed  Google Scholar 

  5. Gaines, G.L. 1966. Insoluble Monolayers at Liquid-Gas Interfaces. Wiley, New York

    Google Scholar 

  6. Hui, S.W., Cowden, M., Papahadjopoulos, D., Parsons, D.F. 1975. Electron diffraction study of hydrated phospholipid single bilayers.Biochim. Biophys. Acta 382:265

    PubMed  Google Scholar 

  7. Jacobson, K., Papahadjopoulos, D. 1975. Phase transitions and phase separations in phospholipid membranes induced by changes in temperature, pH, and concentration of bivalent cations.Biochemistry 14:152

    PubMed  Google Scholar 

  8. Marcelja, S. 1974. Chain ordering in liquid crystals. II. Structure of bilayer membranes.Biochim. Biophys. Acta 367:165

    PubMed  Google Scholar 

  9. Marsh, D. 1974. Statistical mechanics of the fluidity of phospholipid bilayers and membranes.J. Membrane Biol. 18:145

    Google Scholar 

  10. McConnell, H.M., McFarland, B. 1972. The flexibility gradient in biological membranes.Ann. N. Y. Acad. Sci. 195:207

    PubMed  Google Scholar 

  11. Melchior, D.L., Morowitz, H.J. 1972. Dilatometry of dilute suspensions of synthetic lecithin aggregates.Biochemistry 11:4558

    PubMed  Google Scholar 

  12. Michaelson, D.M., Horwitz, A.F., Klein, M.P. 1974. Head group modulation of membrane fluidity in sonicated phospholipid dispersions.Biochemistry 13:2605

    PubMed  Google Scholar 

  13. Nagle, J.F. 1973a. Theory of biomembrane phase transitions.J. Chem. Phys. 58:252

    Google Scholar 

  14. Nagle, J.F. 1973b. Lipid bilayer phase transition: Density measurements and theory.Proc. Nat. Acad. Sci. USA 70:3443

    PubMed  Google Scholar 

  15. Nagle, J.F. 1974. Statistical mechanics of the melting transition in lattice models of polymers.Proc. R. Soc. London, Ser. A 337:569

    Google Scholar 

  16. Nagle, J.F. 1975. Critical points for dimer models with 3/2-order transitions.Phys. Rev. Lett. 34:1150

    Google Scholar 

  17. Nagle, J.F. 1975. Chain model theory of lipid monolayer transitions.J. Chem. Phys. 63:1255

    Google Scholar 

  18. Ohnishi, S., Ito, T. 1974. Calcium-induced phase separations in phosphatidylserine-phosphatidylcholine membranes.Biochemistry 13:881

    Google Scholar 

  19. Oldani, D., Hauser, H., Nichols, B.W., Phillips, M.C. 1975. Monolayer characteristics of some glycolipids at the air-water interface.Biochim. Biophys. Acta 382:1

    PubMed  Google Scholar 

  20. Onsager, L. 1944. Crystal statistics. I. A two-dimensional model with an order-disorder transition.Phys. Rev. 65:117

    Google Scholar 

  21. Phillips, M.C., Cadenhead, D.A., Good, R.J., King, H.F. 1971. Dipole interactions in monomolecular layers.J. Colloid Interface Sci. 37:437

    Google Scholar 

  22. Phillips, M.C., Chapman, D. 1968. Monolayer characteristics of saturated lecithins and phosphatidylethanolamines at the air-water interface.Biochim. Biophys. Acta 163:301

    PubMed  Google Scholar 

  23. Phillips, M.C., Finer, E.G., Hauser, H. 1972. Differences between conformations of lecithin and phosphatidylethanolamine polar groups and their effects on interactions of phospholipid bilayer membranes.Biochim. Biophys. Acta 290:397

    PubMed  Google Scholar 

  24. Phillips, M.C., Graham, D.E., Hauser, H. 1975. Lateral compressibility and penetration into phospholipid monolayers and bilayer membranes.Nature 254:154

    PubMed  Google Scholar 

  25. Poste, G., Papahadjopoulos, D., Jacobson, K., Vail, W.J. 1975. Local anaesthetics increase susceptibility of untransformed cells to agglutination by concanavalin A.Nature 253:552

    PubMed  Google Scholar 

  26. Scott, H.L. 1974. A model for phase transitions in lipid bilayers and biological membranes.J. Theor. Biol. 46:241

    PubMed  Google Scholar 

  27. Scott, H.L. 1975. Some models for lipid bilayer and biomembrane phase transitions.J. Chem. Phys. 62:1347

    Google Scholar 

  28. Srinivasan, K.R., Kay, R.L., Nagle, J.F. 1974. The pressure dependence of the lipid bilayer phase transition.Biochemistry 13:3494

    PubMed  Google Scholar 

  29. Shimshick, E.J., McConnell, H.M. 1973. Lateral phase separation in phospholipid membranes.Biochemistry 12:2351

    Google Scholar 

  30. Simon, S.A., Lis, L.J., Kauffman, J.W., MacDonald, R.C. 1975. A calorimetric and monolayer investigation of the influence of ions on the thermodynamic properties of phosphatidylcholine.Biochim. Biophys. Acta 375:317

    PubMed  Google Scholar 

  31. Singer, S.J., Nicolson, G.L. 1972. The fluid mosaic model of the structure of cell membranes.Science 175:720

    PubMed  Google Scholar 

  32. Tardieu, A., Luzzati, V., Reman, F.C. 1973. Structure and polymorphism of the hydrocarbon chains of lipids.J. Mol. Biol. 75:711

    PubMed  Google Scholar 

  33. Tien, H. Ti 1968. The thermodynamics of bimolecular (black) lipid membranes at the water-oil-water biface.J. Phys. Chem. 72:2723

    PubMed  Google Scholar 

  34. Träuble, H., Eibl, H. 1974. Electrostatic effects on lipid phase transitions.Proc. Nat. Acad. Sci. USA 71:214

    PubMed  Google Scholar 

  35. Trudell, J.R., Payan, D.G., Chin, J.H., Cohen, E.N. 1975. The antagonistic effect of an inhalation anaesthetic and high pressure on the phase diagram of mixed bilayers.Proc. Nat. Acad. Sci. USA 72:210

    PubMed  Google Scholar 

  36. Vaughan, D.J., Keough, K.M. 1974. Changes in phase transitions of phosphatidyl-ethanolamine and phosphatidylcholine water dispersions induced by small modifications in the headgroup and backbone regions.FEBS Lett. 47:158

    PubMed  Google Scholar 

  37. Verkleij, A.J., de Kruyff, B., Ververgaert, P.H.J.Th., Tocanne, J.F., Van Deenen, L.L.M. 1974. The influence of pH, Ca++ and protein on the thermotropic behavior of phosphatidylglycerol.Biochim. Biophy. Acta 339:432

    Google Scholar 

  38. Vilallonga, F. 1968. Surface chemistry ofl-α-dipalmitoyl lecithin at the air-water interface.Biochim. Biophys. Acta 163:290

    PubMed  Google Scholar 

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  1. Physics and Biological Sciences Departments, Carnegie-Mellon University, 15213, Pittsburgh, Pa.

    J. F. Nagle

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Nagle, J.F. Theory of lipid monolayer and bilayer phase transitions: Effect of headgroup interactions. J. Membrain Biol. 27, 233–250 (1976). https://doi.org/10.1007/BF01869138

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  • DOI: https://doi.org/10.1007/BF01869138

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