Skip to main content
Log in

The effects of caffeine on ambulatory blood pressure, heart rate, and mood in coffee drinkers

  • Published:
Journal of Behavioral Medicine Aims and scope Submit manuscript

Abstract

The present study examined the effects of caffeine, as typically ingested through coffee, on ambulatory systolic and diastolic blood pressure (BP), heart rate, and mood. Normotensive coffee drinkers wore a BP monitor for two 24-hr periods, consuming decaffeinated coffee. Each cup was supplemented with 125 mg caffeine or cornstarch. Systolic and diastolic BPs were elevated on the day caffeine was consumed (maximum, 3.6 and 5.6 mm Hg, respectively), most notably shortly after ingestion. Heart rate was higher overnight following caffeine consumption. Negative Affectivity was also increased by caffeine, but Positive Affectivity and tiredness were unaffected.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • American Psychological Association (1992). Ethical principles of psychologists and code of conduct.Am. Psychol. 47: 1597–1611.

    Google Scholar 

  • Barone, J. J., and Grice, H. C. (1994). Meeting report: seventh international caffeine workshop, Santorini, Greece 13–17 June 1993.Food Chem. Tox. 32: 65–77.

    Google Scholar 

  • Benowitz, N. L. (1990). Clinical pharmacology of caffeine.Annu. Rev. Med. 41: 277–288.

    PubMed  Google Scholar 

  • Benowitz, N. L., Hall, S. M., and Modin, G. (1989). Persistent increases in caffeine concentrations in people who stop smoking.Br. Med. J. 298: 1075–1076.

    Google Scholar 

  • Bonham, G. S., and Leaverton, P. E. (1980).Use Habits Among Adults of Cigarettes, Coffee, Aspirin, and Sleeping Pills (Series 10, Vol. 131), Vital Health and Statistics, Washington, DC, pp. 80–1559.

  • Casiglia, E., Bonjiovi, S., Paleari, C. D., Petucco, S., Boni, M., Colangeli, G., Penzo, M., and Pessina, A. C. (1991). Haemodynamic effects of coffee and caffeine in normal volunteers: A placebo-controlled clinical study.J. Int. Med. 229: 501–504.

    Google Scholar 

  • Casiglia, E., Paleari, C. D., Petucco, S., Bonjiovi, S., Colangeli, G., Baccilieri, M. S., Pavan, L., Pernice, M., and Pessina, A. C. (1992). Haemodynamic effects of coffee and purified caffeine in normal volunteers: A placebo-controlled clinical study.J. Hum. Hypertens. 6: 95–99.

    PubMed  Google Scholar 

  • Charney, D. S., Galloway, M. P., and Heninger, G. R. (1984). The effects of caffeine on plasma MHPG, subjective anxiety, autonomic symptoms, and blood pressure in healthy humans.Life Sci. 35: 135–144.

    PubMed  Google Scholar 

  • Eggertsen, R., Andreasson, A., Hedner, T., Karlberg, B. E., and Hansson, L. (1993). Effect of coffee on ambulatory blood pressure in patients with treated hypertension.J. Int. Med. 233: 351–355.

    Google Scholar 

  • France, C., and Ditto, B. (1988). Caffeine effects on several indices of cardiovascular activity at rest and during stress.J. Behav. Med. 11: 473–482.

    PubMed  Google Scholar 

  • France, C., and Ditto, B. (1989). Cardiovascular response to occupational stress and caffeine in telemarketing employees.Psychosom. Med. 51: 145–151.

    PubMed  Google Scholar 

  • Fredholm, B. B. (1984). Cardiovascular and renal effects of methylxanthines. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.), and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 303–330.

    Google Scholar 

  • Gilbert, R. M., Marshman, J. A., Schwieder, M., and Berg, R. (1976). Caffeine content of beverages as consumed.CMA J. 114: 205–208.

    Google Scholar 

  • Gilliland, K., and Andress, D. (1981). Ad lib caffeine consumption, symptoms of caffeinism, and academic performance.Am. J. Psychiat. 138: 512–514.

    PubMed  Google Scholar 

  • Griffiths, R. R., and Woodson, P. P. (1988). Caffeine physical dependence: A review of human and laboratory animal studies.Psychopharmacology. 94: 437–451.

    PubMed  Google Scholar 

  • Griffiths, R. R., Bigelow, G. E., and Liebson, I. A. (1989). Reinforcing effects of caffeine in coffee and capsules.J. Exp. Anal. Behav. 52: 127–140.

    PubMed  Google Scholar 

  • Griffiths, R. R., Evans, S. M., Heishman, S. J., Preston, K. L., Sannerud, C. A., Wolf, B., and Woodson, P. P. (1990). Low-dose caffeine discrimination in humans.J. Pharmacol. Exp. Ther. 252: 970–978.

    PubMed  Google Scholar 

  • Grilly, D. M. (1994).Drugs and Human Behavior (2nd ed), Allyn and Bacon, Boston, pp. 193–196.

    Google Scholar 

  • Hirsh, K. (1984). Central nervous system pharmacology of the dietary methylxanthines. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.), and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 235–302.

    Google Scholar 

  • Hypertension Detection and Follow-up Program Cooperative Group (1979). Five year findings of the Hypertension Detection and Follow-up Program.JAMA 242: 2562–2571.

    Google Scholar 

  • Jeong, D., and Dimsdale, J. E. (1990). The effects of caffeine on blood pressure in the work environment.Am. J. Hypertens. 3: 749–753.

    PubMed  Google Scholar 

  • Lane, J. D. (1983). Caffeine and cardiovascular response to stress.Psychosom. Med. 45: 447–451.

    PubMed  Google Scholar 

  • Lane, J. D. and Manus, D. C. (1989). Persistent cardiovascular effects with repeated caffeine administration.Psychosom. Med. 51: 373–380.

    PubMed  Google Scholar 

  • Lane, J. D., and Williams, R. B. (1987). Cardiovascular effects of caffeine and stress in regular coffee drinkers.Psychophysiology 24: 157–164.

    PubMed  Google Scholar 

  • Loke, W. H. (1988). Effects of caffeine on mood and memory.Physiol. Behav. 44: 367–372.

    PubMed  Google Scholar 

  • Loke, W. H. (1990). Effects of repeated caffeine administration on cognition and mood.Hum. Psychopharmacol. Clin. Exp. 5: 339–348.

    Google Scholar 

  • Lovallo, W. R., Pincomb, G. A., Sung, B. H., Everson, S. A., Passey, R. B., and Wilson, M. F. (1991). Hypertension risk and caffeine's effect on cardiovascular activity during mental stress in young men.Health Psychol. 10: 236–243.

    PubMed  Google Scholar 

  • MacDonald, T. M., Sharpe, K., Fowler, G., Lyons, D., Freestone, S., Lovell, H. G., Webster, J., and Petrei, J. C. (1991). Caffeine restriction: Effect on mild hypertension.Br. Med. J. 303: 1235–1238.

    Google Scholar 

  • Myers, M. G., and Reeves, R. A. (1991). The effect of caffeine on daytime ambulatory blood pressure.Am. J. Hypertens. 4: 427–431.

    PubMed  Google Scholar 

  • Parsons, W. D., and Neims, A. H. (1978). Effect of smoking on caffeine clearance.Clin. Pharmacol. Ther. 24: 40–45.

    PubMed  Google Scholar 

  • Passmore, A. P., Kondowe, G. B., and Johnston, G. D. (1987). Renal and cardiovascular effects of caffeine: A dose-response study.Clin. Sci. 72: 749–756.

    PubMed  Google Scholar 

  • Periti, M., Salvaggio, A., Quaglia, G., and DiMarzio, L. (1987). Coffee consumption and blood pressure: An Italian study.Clin. Sci. 72: 443–447.

    PubMed  Google Scholar 

  • Pickering, T. G. (1980). Sleep, circadian rhythms, and cardiovascular disease.Cardiovasc. Rev. Rep. 1: 37–46.

    Google Scholar 

  • Pincomb, G. A., Lovallo, W. R., Passey, R. B., Whitsett, T. L., Silverstein, S. M., and Wilson, M. F. (1985). Effects of caffeine on vascular resistance, cardiac output and myocardial contractility in young men.Am. J. Cardiol. 56: 119–122.

    PubMed  Google Scholar 

  • Robertson, D., Frolich, J. C., Carr, R. K., Watson, J. T., Hollifield, J. W., Shand, D. G., and Oats, J. A. (1978). Effects of caffeine on plasma renin activity, catecholamines, and blood pressure.N. Engl. J. Med. 298: 181–186.

    PubMed  Google Scholar 

  • Robertson, D., Wade, D., Workmsn, R., Woosley, R. L., and Oats, J. A. (1981). Tolerance to the humoral and hemodynamic effects of caffeine in man.J. Clin. Invest. 67: 1111–1117.

    PubMed  Google Scholar 

  • Shi, J., Benowitz, N. L., Denaro, C. P., and Sheiner, L. B. (1993). Pharmacokinetic-pharmacodynamic modeling of caffeine: Tolerance to pressor effects.Clin. Pharmacol. Ther. 53: 6–14.

    PubMed  Google Scholar 

  • Silverman, K., and Griffiths, R. R. (1992). Low-dose caffeine discrimination and self-reported mood effects in normal volunteers.J. Exp. Behav. 57: 91–107.

    Google Scholar 

  • Southard, D. R., Coates, T. J., Kolodner, K., Parker, F. C., Padgett, N. E., and Kennedy, H. L. (1986). Relationship between mood and blood pressure in the natural environment: An adolescent population.Health Psychol. 5: 469–480.

    PubMed  Google Scholar 

  • Spiller, G. A. (1984). Overview of the methylxanthine beverages and foods and their effect on health. In Black, N., Brewer, G. J., Eijsvoogel, V. P., Grover, R., Hirschhorn, K., Kety, S. S., Udenfriend, S., and Uhr, J. W. (ser. eds.) and Spiller, G. A. (vol. ed.),Progress in Clinical and Biological Research: Vol. 158. The Methylxanthine Beverages and Foods, Alan R. Liss, New York, pp. 1–8.

    Google Scholar 

  • Sung, B. H., Lovallo, W. R., Pincomb, G. A., and Wilson, M. F. (1990). Effects of caffeine on blood pressure response during exercise in normotensive healthy young men.Am. J. Cardiol. 65: 909–913.

    PubMed  Google Scholar 

  • Superko, H. R., Myll, J., DiRicco, C., Williams, P. T., Bortz, W. M., and Wood, P. D. (1993). Effects of cessation of caffeinated-coffee consumption on ambulatory blood pressure and resting blood pressure in men.Am. J. Cardiol. 73: 780–784.

    Google Scholar 

  • Van Dusseldorp, M., and Katan, M. B. (1990). Headache caused by caffeine withdrawal among moderate coffee drinkers switched from ordinary to decaffeinated coffee: A 12-week double-blind trial.Br. Med. J. 300: 1558–1559.

    Google Scholar 

  • Van Dusseldorp, M., Smits, P., Thein, T., and Katan, M. B. (1989). Effects of decaffeinated versus regular coffe on blood pressure.Hypertension 14: 563–569.

    PubMed  Google Scholar 

  • Van Dusseldorp, M., Smits, P., Lenders, J. W. M., Thein, T., and Katan, M. B. (1991). Boiled coffee and blood pressure: A 14-week controlled trial.Hypertension 18: 607–613.

    PubMed  Google Scholar 

  • Watson, D. (1988). The vicissitudes of mood measurement: Effect of varying descriptors, time frames, and response formats on measures of positive and negative affect.J. Person. Soc. Psychol. 55: 128–141.

    Google Scholar 

  • Watson, D., and Tellegen, A. (1985). Toward a consensual structure of mood.Psychol. Bull. 98: 219–235.

    PubMed  Google Scholar 

  • Watson, D., Clark, L. A., and Tellegen, A. (1988). Development and validation of brief measures of positive and negative affect: The PANAS Scales.J. Person. Soc. Psychol. 54: 1063–1070.

    Google Scholar 

  • White, B. C., Lincoln, C. A., Pearce, N. W., Reeb, R., and Vaida, C. (1980). Anxiety and muscle tension as consequences of caffeine withdrawal.Science 209: 1547–1548.

    PubMed  Google Scholar 

  • Zwyghuizen-Doorenbos, A., Roehrs, T. A., Lipschutz, L., Timms, V., and Roth, T. (1990) Effects of caffeine on alertness.Psychopharmacology 100: 36–39.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

Green, P.J., Suls, J. The effects of caffeine on ambulatory blood pressure, heart rate, and mood in coffee drinkers. J Behav Med 19, 111–128 (1996). https://doi.org/10.1007/BF01857602

Download citation

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01857602

Key words

Navigation