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Surface markers of resting and activated human T cells. Functional implications and experimental limits

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References

  1. Accolla RS, Gross N, Carrel S, Corte G (1981) Distinct forms of both α and β subunits are present in the human la molecular pool. Proc Natl Acad Sci USA 78: 4549

    PubMed  Google Scholar 

  2. Accolla RS, Moretta A, Cerottini JC (1981) Allogeneic mixed lymphocyte reactions in humans: pretreatment of either the stimulator or the responder cell population with monoclonal anti-Ia antibodies leads to an inhibition of cell proliferation. J Immunol 127: 2438

    PubMed  Google Scholar 

  3. Aiuti F, Wigzell H (1973) Function and distribution pattern of human T lymphocytes. I. Production of anti-T lymphocyte specific sera as estimated by cytotoxicity and elimination of function of lymphocytes. Clin Exp Immunol 13: 171

    PubMed  Google Scholar 

  4. Albrechtsen D, Solheim BG, Thorsby E (1977) Antiserum inhibition of mixed lymphocyte culture (MLC) interaction. Inhibitory effect of antibodies reactive with HLA-D-associated determinants. Cell Immunol 28: 258

    PubMed  Google Scholar 

  5. Balch CM, Dougherty PA, Dagg MK, Diethelm AG, Lawton AR (1977) Detection of human T cells using anti-monkey thymocyte antisera: Tissue distribution and evidence for antigenic heterogeneity. Clin Immunol Immunopathol 8: 448

    PubMed  Google Scholar 

  6. Balch CM, Lawton AR, Cooper MD (1976) Preparation of heterologous antisera specific for human T cells. In: Bloom BR, David JR (eds) In vitro methods in cell-mediated immunity. Academic Press, New York, p 105

    Google Scholar 

  7. Brain P, Gordon J, Willetts WA (1970) Rosette formation by peripheral lymphocytes. Clin Exp Immunol 6: 681

    PubMed  Google Scholar 

  8. Brown G, Greaves MF (1974) Cell surface markers for human T and B lymphocytes. Eur J Immunol 4: 302

    PubMed  Google Scholar 

  9. Canonica GW, Pistoia V, Ghio R, Mingari MC, Moretta L (1980) Suppressor activity of T cell bearing Fe receptors for IgG on lymphoid colony formation. Scand J Immunol 12: 507

    PubMed  Google Scholar 

  10. Colombatti M, Heumann D, Moretta L (1981) Distribution and properties of Fc receptors for IgG on different leukocyte populations in man. Clin Exp Immunol 46: 453

    PubMed  Google Scholar 

  11. Coombs RR, Gurner BW, Wilson AB (1970) Rosette formation between human lymphocytes and sheep red cells not involving immunoglobulin receptors. Int Arch Allergy Appl Immunol 39: 658

    PubMed  Google Scholar 

  12. Cordier G, Samarut Ch, Revillard JP (1977) Changes of Fc-receptor-related properties induced by interaction of human lymphocytes with insoluble immune complexes. J Immunol 119: 1943

    PubMed  Google Scholar 

  13. Corte G, Calabi F, Damiani G, Bargellesi A, Tosi R, Sorrentino R (1981) Human la molecules carrying DC1 determinants differ in bothα andβ subunits from la molecules carrying DR determinants. Nature 2921: 357

    Google Scholar 

  14. Corte G, Mingari MC, Moretta A, Damiani G, Moretta L, Bargellesi A (1982) Human T cell subpopulations defined by a monoclonal antibody. I. A small subset is responsible for proliferation to allogeneic cells or to soluble antigens and for helper activity for B cell differentiation. J Immunol 118: 16

    Google Scholar 

  15. Corte G, Moretta L, Damiani G, Mingari MC, Bargellesi A (1981) Surface antigens specially expressed by activated T cells in humans. Eur J Immunol 11: 162

    PubMed  Google Scholar 

  16. Dickler HB (1976) Lymphocyte receptor for immunoglobulin. In Adv Immunol (Dixon F.J. and Kunkel, H. G. Eds): 167

  17. Eisenbarth GS, Haynes BJ, Schroer JA, Fauci AS (1980) Production of monoclonal antibodies reacting with peripheral blood mononuclear cell surface differentiation antigens. J Immunol 126: 1237

    Google Scholar 

  18. Engleman EG, Warnke R, Fox RI, Levy R (1981) Studies of a human T lymphocyte antigen recognized by a monoclonal antibody. Proc Natl Acad Sci USA 78: 1791

    PubMed  Google Scholar 

  19. Evans RL, Breard JM, Lazarus H, Schlossman SF, Chess L (1977) Detection, isolation and functional characterization of two human T-cell subclasses bearing unique differentiation antigens. J Exp Med 145: 221

    PubMed  Google Scholar 

  20. Evans RL, Faldetta TJ, Humphreys RE, Pratt DM, Yunis EJ, Schlossman SF (1978) Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express la-like antigens. J Exp Med 148: 1440

    PubMed  Google Scholar 

  21. Ferrarini M, Moretta L, Abrile R, Durante ML (1975) Receptors for IgG molecules on human lymphocytes forming spontaneous rosettes with sheep red cells. J Immunol 5: 70

    Google Scholar 

  22. Fridman WH, Rabourdin-Combes C, Neauport-Sautes C, Gisler RH (1981) Characterization and function of T cell Fcγ receptor. Immunol Rev 56: 51

    PubMed  Google Scholar 

  23. Greaves MF, Janossy G (1976) Antisera to human T lymphocytes. In: Bloom BR, David JR (eds) In vitro methods in cell-mediated and tumor immunity. Academic Press, New York p 89

    Google Scholar 

  24. Haynes BF, Katz P, Fauci AS (1980) Immune responses of human lymphocytes in vitro. Prog Clin Immunol 23

  25. Haynes BF, Mann DL, Hemler ME, Schroer HA, Shelhamer HH, Eisenbarth GS, Strominger JL, Thomas CA, Mostowski HS, Fauci AS (1980) Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci USA 77: 2914

    PubMed  Google Scholar 

  26. Humphreys RE, McCune JM, Chess L, Herrman HC, Malenka DJ, Mann DL, Parham P, Schlossman SF, Strominger JL (1976) Isolation and immunologic characterization of a human lymphocyte specific cell surface antigen. J Exp Med 144: 98

    Google Scholar 

  27. Kratzin H, Yang C, Gotz H, Pauly E, Kolbel S, Enpert G, Thinnes FP, Wernet P, Altevogt P, Hilsehmann N (1981) Primärstruktur menschlicher Histokompatibilitätsantigene der Klasse II Aminosäuresequenz der N-Terminalen 198 Reste der Kette des HLA-DW 2,2, DR 2, 2, Alloantigens. Hoppe-Seyler's Z Physiol Chem 362: 1655

    Google Scholar 

  28. Jondal M, Holm G, Wigzell H (1972) Surface markers on human T and B lymphocytes: I. A large population of lymphocytes forming nonimmune rosettes with sheep red blood cells. J Exp Med 136: 207

    PubMed  Google Scholar 

  29. Ledbetter JA, Evans RL, Lipinski M, Cunningham-Rundles C, Good RA, Herzenberg LA (1981) Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J Exp Med 153: 310

    PubMed  Google Scholar 

  30. Le Thi Bich-Thuy, Samarut C, Brochier J, Fridman WH, Revillard JP (1980) Suppression of mitogeninduced peripheral B cell differentiation by soluble receptors for FcIgG released from lymphocytes. Eur J Immunol 10: 894

    PubMed  Google Scholar 

  31. Malissen B, Rebai N, Liabeuf A, Mawas C (to be published) Human cytotoxic T cell structures associated with expression of cytolysis. I. Analysis at the clonal cell level of the cytolysis inhibiting effect of seven monoclonal antibodies. Eur J Immunol

  32. bis. Mingari MC, Melioli G, Moretta A, Pantaleo G, Moretta L (1983) Surface markers of cloned human T cells with helper to suppressor activity on Pokeweed mitogen-driven B-cell differentiation. Eur J Immunol (in press)

  33. Mingari MC, Moretta L, Moretta A, Ferrarini M, Preud'homme JL (1978) Fc-receptors for IgG and IgM immunoglobulins on human T-lymphocytes: mode of reexpression after proteolysis or interaction with immune complexes. J Immunol 121: 767

    PubMed  Google Scholar 

  34. Mingari MC, Moretta L (1982) Role of Ia antigens in the human autologous mixed lymphocyte reaction. Eur J Immunol 12: 98

    PubMed  Google Scholar 

  35. Möller G (ed) (1980) T cell stimulating growth factors. Immunol Rev 51

  36. Möller G (ed) 1980 T cell clones. Immunol Rev

  37. Moretta A, Accolla RS, Cerottini JC (1982) IL-2 mediated T cell proliferation in human is blocked by a monoclonal antibody directed against monomorphic determinants of HLA-DR antigens. J Exp Med 155: 599

    PubMed  Google Scholar 

  38. Moretta L, Ferrarini M, Cooper MD (1978) Characterization of human T cell subpopulations as defined by specific receptors for immunoglobulins. Contemp Top Immunobiol 8: 19

    PubMed  Google Scholar 

  39. Moretta L, Ferrarini M, Durante ML, Mingari MC (1975) Expression of a receptor for IgM by human T cells in vitro. Eur J Immunol 5: 565

    PubMed  Google Scholar 

  40. Moretta L, Ferrarini M, Mingari MC, Moretta A, Webb SR (1976) Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsivness. J Immunol 117: 2171

    PubMed  Google Scholar 

  41. Moretta A, Mingari MC, Colombatti M, Moretta L (1981) Fc receptors on human T lymphocytes: loss of Fcµ and expression of Fcγ receptors by T cells stimulated in mixed lymphocyte reactions. Scand J Immunol 13: 447

    PubMed  Google Scholar 

  42. Moretta A, Mingari MC, Haynes BF, Sekaly RP, Moretta L, Fauci AS (1981) Phenotypic characterization of human cytolytic T lymphocytes generated in mixed lymphocyte culture. J Exp Med 153: 213

    PubMed  Google Scholar 

  43. Moretta L, Mingari MC, Moretta A (1979) Human T cell subpopulations in normal and pathologic conditions. Immunol Rev 45: 163

    PubMed  Google Scholar 

  44. Moretta L, Mingari MC, Romanzi CA (1978) Loss of Fc-receptors for IgG from human T lymphocytes exposed to IgG immune complexes. Nature 272: 618

    PubMed  Google Scholar 

  45. Moretta L, Mingari MC, Sekaly RP, Moretta A, Chapuis B, Cerottini JC (1981) Surface markers of cloned human T cells with various cytolytic activities. J Exp Med 154: 569

    PubMed  Google Scholar 

  46. Moretta L, Moretta A, Canonica GW, Bacigalupo A, Mingari MC, Cerottini JC (1981) Receptors for immunoglobulins on resting and activated human T cells. Immunol Rev 56: 141

    PubMed  Google Scholar 

  47. bis. Moretta A, Pantaleo G, Moretta L, Cerottini JC, Mingari MC (1983) Direct demonstration of the clonogenic potential of every human peripheral blood T cell. Clonal analysis of HLA-DR expression and cytolytic activity. J Exp Med (in press)

  48. Moretta L, Webb SR, Grossi CE, Lydyard PM, Cooper MD (1977) Functional analysis of two human T cell subpopulations: Help and suppression of B cell responses by T cells bearing receptors for IgM (TM) or IgG (TG). J Exp Med 146: 184

    PubMed  Google Scholar 

  49. Perlmann P, Perlmann H, Moretta L, Rönnholm M (1981): Regulation of IgG-antibody dependent cellular cytotoxicity in vitro by IgM-antibodies. Scand J Immunol 14: 47

    PubMed  Google Scholar 

  50. Platsoucas CD, Good RA (1981) Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens. Proc Natl Acad Sci USA 78: 4500

    PubMed  Google Scholar 

  51. Playfair JHL (1974) The role of antibody in T-cell responses. Clin Exp Immunol 17: 1

    PubMed  Google Scholar 

  52. Raff MC (1970) Two distinct populations of peripheral lymphocytes in mice distinguishable by immunofluorescence. Immunol 19: 637

    Google Scholar 

  53. Reinherz EL, Hussey RE, Fitzgerald K, Snow P, Terhorst C, Sclossman SF (1981) Antibody directed at a surface structure inhibits cytolytic but not suppressor function of human T lymphocytes. Nature 294: 168

    PubMed  Google Scholar 

  54. Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1979) A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol 123: 1312

    PubMed  Google Scholar 

  55. Reinherz EL, Kung PC, Goldstein G, Schlossman SF (1980) A monoclonal antibody reactive with the human cytotoxic suppressor T cell subset previously defined by an heteroantibody termed TH2. J Immunol 124: 1301

    PubMed  Google Scholar 

  56. Reinherz EL, Morimoto C, Fitzgerald KA, Hussey RE, Daley JF, Sclossman SF (1982) Heterogeneity of human T4 inducer T cells defined by a monoclonal antibody that delineates two functional subpopulations. J Immunol 128: 463

    PubMed  Google Scholar 

  57. Reinherz EL, Morimoto C, Penta AC, Schlossman SF (1980) Regulation of B cell immunoglobulin secretion by functional subsets of T lymphocytes in man. Eur J Immunol 10: 570

    PubMed  Google Scholar 

  58. Reinherz EL, Schlossman SF (1980) The differentiation and function of human T lymphocytes. Cell 19: 821

    PubMed  Google Scholar 

  59. Schlossman SF, Chess L, Humphreys RE, Strominger JL (1976) Distribution of la-like molecules on the surface of normal and leukemic cells. Proc Nall Acad Sci USA 73: 1288

    Google Scholar 

  60. Silverstein SC, Steinman RM, Cohn ZA (1977) Endocytosis. Annu Rev Biochem 46: 669

    PubMed  Google Scholar 

  61. Sinclair NRS (1969) Regulation of the immune response. I. Reduction in ability of specific antibody to inhibit long-lasting IgG immunological priming after removal of the Fc fragment. J Exp Med 129: 1183

    PubMed  Google Scholar 

  62. Snary D, Barnstahle CJ, Bodmer WF, Goodfellow PM, Crumpton MJ (1977) Cellular distribution, purification and molecular nature of human Ia antigens. Scand J Immunol 6: 439

    PubMed  Google Scholar 

  63. Sulica A, Gherman M, Medesan C, Sjöquist J, Ghetie V (1979) IgG-binding sites on macrophage cell membrane. I. Identification of two distinct Fc receptors on mouse peritoneal macrophages. Eur J Immunol 9: 979

    PubMed  Google Scholar 

  64. Tosi R, Tanigaki N, Centis D, Ferrara GB, Pressman D (1978) Immunological dissection of human Ia molecules. J Exp Med 148: 1592

    PubMed  Google Scholar 

  65. Van Rood JJ, Van Leuwen A, Termiitelen A, Kevning JJ (1976) In: Katz DH, Benacerraf B (eds) The role of products of the histocompatibility gene complex in immune response. Academic Press, New York, p 51

    Google Scholar 

  66. Winchester RJ, Kunkel HG (1980) The human la system. Adv Immunol 28: 22

    Google Scholar 

  67. Wybran J, Carr MC, Fudenberg HH (1972) The human rosette-forming cell as a marker of a population of thymus-derived cells. J Clin Invest 51: 2537

    PubMed  Google Scholar 

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Authors and Affiliations

  1. Lausanne Branch Chemin des Boveresses, Ludwig Institute for Cancer Research, CH-1066, Epalinges, Switzerland

    Maria Cristina Mingari, Alessandro Moretta & Lorenzo Moretta

  2. Istituto di Patologia Medica, University of Bari, Italy

    Giuseppe Pantaleo

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  1. Maria Cristina Mingari
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  2. Alessandro Moretta
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  3. Giuseppe Pantaleo
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  4. Lorenzo Moretta
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Mingari, M.C., Moretta, A., Pantaleo, G. et al. Surface markers of resting and activated human T cells. Functional implications and experimental limits. Springer Semin Immunopathol 5, 477–488 (1982). https://doi.org/10.1007/BF01857432

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