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Network regulation among T cells; Conclusions from limiting dilution experiments

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Abbreviations

Con A :

Concanavalin A

Con A sup :

Con A induced supernatant of rat spleen cells

TCGF :

T cell growth factors

MHC:

major histocompatibility complex

allo-H-2 :

allogeneic major histocompatibility antigens

H-minor :

minor histocompatibility antigens

TNP :

trinitrophenyl

TNBS :

trinitrobenzenesulfonic acid

TNCB :

trinitrochlorobenzene

TNP-Cap-Glu-Glu :

TNP-caproic acid-N-diglutamyl

SRBC :

sheep red blood cells

HRBC :

horse red blood cells

CRBC :

chicken red blood cells

Strep. A :

Group A streptococci

T E :

effector T cell

T S :

suppressor T cell

T H :

helper T cell

CTL :

cytotoxic T cell

P :

precursor

CFC :

clone-forming cell

F o :

probability to observe a negative culture

N :

cell number ø frequency

u=<j>=ø E .N :

multiplicity of effector T cells distributed around exact number j of TE

v=<i>=ø S .N :

multiplicity of suppressor T cells distributed around exact number i of TS

R=ø E /ø S ratio :

A(j): number of TS needed to suppress a culture containing j TE.

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  1. Max-Planck-Institute for Immunobiology, Stübeweg 51, Postfach 1169, D-7800, Freiburg-Zähringen, Germany

    K. Eichmann, K. Fey, R. Kuppers, I. Melchers, M. M. Simon & H. U. Weltzien

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Eichmann, K., Fey, K., Kuppers, R. et al. Network regulation among T cells; Conclusions from limiting dilution experiments. Springer Semin Immunopathol 6, 7–32 (1983). https://doi.org/10.1007/BF01857364

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