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Dendritic cells in rheumatoid inflammation

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Conclusions

Rheumatoid inflammatory synovial and blood DC seem to have the same characteristics as LDC. Thus, the cells are strongly positive for class II MHC antigens and the common leukocyte antigen, while they lack almost all other mononuclear cell markers. Rheumatoid DC also produce IL-1, a cytokine which has many different functions in the rheumatoid inflammation. IL-1 is involved in tissue destruction and in triggering of T lymphocytes as well as in the maturation of B lymphocytes. The rheumatoid synovial DC are potent accessory cells for T cell responses and probably play an important role for starting and perpetuating the chronic rheumatoid inflammation. To further characterize the DC, we need reliable methods for the purification of these cells. Thus, it is important to clone DC and to produce monoclonal antibodies specific for human blood and synovial DC surface antigens.

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Authors and Affiliations

  1. Institute of Immunology and Rheumatology, University of Oslo, Fredrikke, Qvamsgate 1, N-0172, Oslo 1, Norway

    Kristian Waalen & Jacob B. Natvig

  2. Oslo Sanitetsforenings Rheumatism Hospital, Akersbakken 27, N-0172, Oslo 1, Norway

    Øystein Førre

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  3. Jacob B. Natvig
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Waalen, K., Førre, Ø. & Natvig, J.B. Dendritic cells in rheumatoid inflammation. Springer Semin Immunopathol 10, 141–156 (1988). https://doi.org/10.1007/BF01857220

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