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The influences of acute hyper- and hypocalcemia and of calcitonin on exocrine pancreatic function in man

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Research in Experimental Medicine

Summary

The influences of acute changes of the serum calcium and of calcitonin (CT) on the exocrine pancreatic function have been studied in man. During stimulation with secretin and cholecystokinin-pancreozymin (CCK-PZ) Ca++-glucolactobionate, Na2-EDTA, porcine and human synthetic CT were infused i.v. Hypercalcemia provoked an increase of enzyme secretion under unstimulated and secretin stimulated conditions; however, in the case of CCK-PZ administration enzyme output was not altered. EDTA-hypocalcemia inhibited pancreatic secretion during secretin as well as during CCK-PZ infusions. CT doses above 2 MRCU caused a decrease of enzyme secretion during simultanous secretin/CCK-PZ administration by about 70–80% of the initial value without decreasing serum Ca++; doses of 0.5 MRCU and less were without effect. In none of the experiments bicarbonate secretion was affected. The results show important changes of the pancreatic enzyme secretion during acute hyper- and hypocalcemia, while calcitonin exerts an inhibitory effect during normocalcemia.

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Authors and Affiliations

  1. Section of Gastroenterology, Center of Internal Medicine and Pediatrics, University of Ulm, Steinhövelstraße 9, D-7900, Ulm, Federal Republic of Germany

    J. Hotz

  2. Department of Internal Medicine, Endocrinology and Metabolism, Center of Internal Medicine and Pediatrics, University of Ulm, West-Germany

    H. Minne & R. Ziegler

Authors
  1. J. Hotz
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  2. H. Minne
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  3. R. Ziegler
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We wish to thank Mrs. H. Steger and Miss D. Riesenhuber for their skilful technical assistance.

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Hotz, J., Minne, H. & Ziegler, R. The influences of acute hyper- and hypocalcemia and of calcitonin on exocrine pancreatic function in man. Res. Exp. Med. 160, 152–165 (1973). https://doi.org/10.1007/BF01852252

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  • DOI: https://doi.org/10.1007/BF01852252

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