Summary
To study the survival time of kidney-transplants in closely related species cat kidneys were transplanted to the iliac vessels of mongrel dogs by an “en bloc” method. A type of delayed hyperacute rejection was observed. The function time of the transplant kidneys ranged from 15 to 24 hrs. The decrease of complement activity and the appearance of cat-tissue protein in serum and urine samples show that the rejection began at an early stage. Since the antigen-antibody reaction seems to be finished after 6 hrs, indicated by an increase of complementactivity, the final loss of function may be effected by an unspecific reaction. Recipients survived after removal of the transplant and got a second kidney graft 3 weeks after the first set. These kidneys were rejected within 15–20 min with the sign of typical hyperacute rejection.
Zusammenfassung
Um das Verhalten vascularisierter Xenotransplantate zwischen Tieren enger zoologischer Verwandtschaft zu untersuchen, wurden Katzennieren „en bloc“ auf Hunde transplantiert. In diesem System zeigte sich, mit einer Funktionsdauer von 15–24 Std, der Typ einer verzögert hyperakuten Abstoßung. Der Abfall des Komplements im peripheren Blut und das Auftreten von Katzenprotein im Urin schon während der ersten Stunden deutet auf einen früheren Beginn dieser Reaktion hin, während die endgültige Zerstörung des Transplantates durch unspezifische, jedoch von der Antigen-Antikörper-Reaktion gestartete Mechanismen bedingt zu sein scheint. Den Empfängern dieser Ersttransplantate wurden 3 Wochen später mit einer Ex vivo-Hämoperfusion eine zweite Katzenniere angeschlossen. Innerhalb von 15–20 min waren diese Nieren unter dem Bild einer typischen hyperakuten Abstoßung zerstört.
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Abbreviations
- CFA:
-
complement fixing antibodies
- C'H-50:
-
50% hemolytic complement activity
- Hagg.:
-
Hemagglutinins
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Dedicated to Prof. Dr. Dr. R. Zenker for his 70th birthday.
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Chaussy, C., Hammer, C., v. Scheel, J. et al. Experimental xenogeneic kidney transplantation in closely related species. Res. Exp. Med. 159, 266–275 (1973). https://doi.org/10.1007/BF01851601
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DOI: https://doi.org/10.1007/BF01851601