Summary
An evaluation of the potential role of the kidney in the regulation of the blood citrate level under different acid-base statuses and various diets was performed. Twenty-four hours after bilateral nephrectomy there was a highly significant increase in the blood citrate concentrations in female rats, whereas the blood citrate levels either remained unchanged or decreased in bilateral nephrectomized male animals. Our data clearly indicate a key role of sex dependency on kidney citrate metabolism in the rat.
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References
Milne MD, Scribner BH, Crawford MA (1958) Non-ionic diffusion and the excretion of weak acids and bases. Am J Med 24:709–715
Clarke E, Evans BM, MacIntyre I, Milne MD (1955) Acidosis in experimental electrolyte depletion. Clin Sci 14:421–440
Fourman P, Robinson JR (1953) Diminished urinary excretion of citrate during deficiencies of potassium in man. Lancet II:656–657
Harrison HE, Harrison HC (1955) Inhibition of urine citrate excretion and the production of renal calcinosis in the rat by acetazoleamide (Diamox) administration. J Clin Invest 34:1662–1670
Gordon EE, Sheps SG (1957) Effect of acetazolamide on citrate excretion and formation of renal calculi. Report of a case and study of five normal subjects. N Engl J Med 256:1215–1219
Gordon EE (1963) Effect of acute metabolic acidosis and alkalosis on acetate and citrate metabolism in the rat. J Clin Invest 42:137–142
Angielski S, Lukowicz J (1978) The role of the kidney in the removal of ketone bodies under different acid-base status of the rat. Am J Clin Nutr 31:1635–1641
Nieth H, Schollmeyer P (1966) Substrate-utilization of the human kidney. Nature 209:1244–1245
Balagura-Baruch S, Burich RL, King VF (1973) Effects of alkalosis on renal citrate metabolism in dogs infused with citrate. Am J Physiol 225:385–388
Martensson J (1940) On the citric acid metabolism in mammals. Acta Physiol Scand [Suppl 2] 1:1–96
Om P, Hohenegger M (1980) Energy metabolism in acute uremic rats. Nephron 25:249–253
Bergmeyer HU (1974) Methoden der enzymatischen Analyse. Verlag Chemie, Weinheim
Simpson DP (1963) Effect of nephrectomy on citrate metabolism in the rat. Am J Physiol 205:1049–1052
Cohen JJ, Kamm DE (1981) Renal metabolism: relation to renal function. In: Brenner BM, Rector FC (eds) The kidney, 2nd edn. Saunders, Philadelphia London Toronto, pp 144–248
Henneman DH, Shoemaker WC (1961) Effect of glucagon and epinephrine on regional metabolism of glucose, pyruvate, lactate, and citrate in normal conscious dogs. Endocrinology 68:889–898
Hörl WH, Schäfer RM, Heidland A (1984) Metabolic changes in acutely uraemic rats following dietary potassium depletion. Nephron (submitted)
Hörl WH, Kluthe R, Gierlach P, Schollmeyer P (1984) Kidney-independent serine synthesis in the rat. Effect of dietary serine and glycine restriction. Nephron (submitted)
Fleischner G, Robbins J, Arias IM (1972) Immunological studies of Y protein. J Clin Invest 51:677–684
Habig WH, Pabst MJ, Fleischner G, Gatmaitan Z, Arias IM, Jakoby WB (1974) The identity of glutathione S-transferase B with ligandin, a major binding protein of liver. Proc Natl Acad Sci USA 71:3879–3882
Lemieux G, Achkar M, Vinay P, Gougoux A (1981) The effect of acid-base status on renal utilization of ketone bodies. In vitro studies in the rat. Proc 8th Int Congr Nephrol, Athens, pp 834–840
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Supported by the Deutsche Forschungsgemeinschaft (Ho 781/3-3) and by the Österreichischer Fond zur Förderung der wissenschaftlichen Forschung (project no. 3364)
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Hörl, W.H., Echsel, E. & Hohenegger, M. The key role of sex dependency on kidney citrate metabolism in the rat. Res. Exp. Med. 185, 69–75 (1985). https://doi.org/10.1007/BF01851530
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DOI: https://doi.org/10.1007/BF01851530