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Split of HLA-DRw2 into subtypic specificities closely correlated to two HLA-D products

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Abstract

Two B-lymphocyte-specific human alloantisera were studied, PA59 and 51.23. They identify two new HLA-DR alleles, which are both subtypic to HLA-DRw2. Moreover, they are closely correlated with two HLA-D products, Dw2 and tb24 (tb24 is a new specificity described by our group). Thus, DRw2 can be “split” into two subtypic specificities that have been named TO60 and TO61, which appear more strongly correlated with HLA-D antigens. Absorption studies demonstrated cytotoxicity-negative, absorption-positive (CYNAP) reactions, and cross-reactive groups of antibodies.

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Authors and Affiliations

  1. Centro CNR Immunogenetica ed Istocompatibilità, Institute of Medical Genetics, University of Turin, Via Santena 19, 10126, Turin, Italy

    Patricia Richiardi, Mariaclara Belvedere, Iolanda Borelli, Mario De Marchi & Emilio Sergio Curtoni

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  1. Patricia Richiardi
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  2. Mariaclara Belvedere
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  3. Iolanda Borelli
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  4. Mario De Marchi
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  5. Emilio Sergio Curtoni
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Richiardi, P., Belvedere, M., Borelli, I. et al. Split of HLA-DRw2 into subtypic specificities closely correlated to two HLA-D products. Immunogenetics 7, 57–61 (1978). https://doi.org/10.1007/BF01843988

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  • DOI: https://doi.org/10.1007/BF01843988

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