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Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice

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Abstract

The unresponsiveness to LPS detected in C57BL/10Cr mice is inherited as a recessive trait and is determined by an autosomal gene linked to theMup-1 locus on chromosome 4. Since no complementation for LPS responsiveness was observed in F1 hybrid mice between C3H/HeJ and C57BL/10Cr, we conclude that C57BL/10Cr mice carry a defective allele at the sameLps locus, previously identified by the mutation detected in the C3H/HeJ strain.

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Authors and Affiliations

  1. Basel Institute for Immunology, Grenzacherstrasse 487, Postfach, 4005, Basel 5, Switzerland

    Antonio Coutinho & Tommaso Meo

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  1. Antonio Coutinho
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  2. Tommaso Meo
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Coutinho, A., Meo, T. Genetic basis for unresponsiveness to lipopolysaccharide in C57BL/10Cr mice. Immunogenetics 7, 17–24 (1978). https://doi.org/10.1007/BF01843983

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  • DOI: https://doi.org/10.1007/BF01843983

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