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A case of congenital leukemia with monosomy 7

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Summary

A case of congenital leukemia with monosomy 7 is reported. Immunological study of the blast cells using monoclonal antibodies was suggestive of both myelomegakaryocytic and T-lymphoblastic leukemia. Chromosomal analysis of the bone marrow cells showed monosomy 7. Chemotherapy was initiated with a combination of adriamycin, cytosine arabinoside, 6-mercaptopurine, and prednisolone. The patient obtained complete remission, which has been maintained for 4 years and 1 month. He receives no chemotherapy now. Our case shows that monosomy 7 in congenital leukemia is rare, but the presence of monosomy 7 in congenital leukemia does not necessarily indicate a poor prognosis.

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Authors and Affiliations

  1. Department of Pediatrics, Gunma University School of Medicine 3-39-15, Showa-machi, Maebashi City, 371, Gunma, Japan

    Toshiji Shitara, Noriyuki Suetake, Shin -Ichiroh Yugami, Manabu Sotomatu, Yukio Oshima, Hiroko Ijima & Takayoshi Kuroume

  2. Department of Pediatrics, Yamanashi Medical College 1110, Shimokato, Tkmaho-cho, Nakakomagun, 409-38, Yamanashi, Japan

    Shinpei Nakazawa

Authors
  1. Toshiji Shitara
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  2. Noriyuki Suetake
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  3. Shin -Ichiroh Yugami
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  4. Manabu Sotomatu
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  5. Yukio Oshima
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  6. Hiroko Ijima
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  7. Takayoshi Kuroume
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  8. Shinpei Nakazawa
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Shitara, T., Suetake, N., Yugami, S.I. et al. A case of congenital leukemia with monosomy 7. Ann Hematol 65, 274–277 (1992). https://doi.org/10.1007/BF01836073

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  • DOI: https://doi.org/10.1007/BF01836073

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