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Arterial bridging for repair of peripheral nerve gap: a comparative study

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Summary

A new experimental model was designed in which the regeneration of rat femoral nerve across a 8 mm excised gap was investigated after insertion of the distal and proximal stumps into the anatomically and functionally intact femoral artery (AIAB). This model was compared with groups of free artery and autologous nerve grafting. After a period of 12 weeks, a histological and electrophysiological analysis was carried out, which demonstrated that the AIAB and autologous nerve grafting group had a significantly higher percentage of regeneration compared with the free artery-graft group. The nerve regeneration and intraneural vascular reconstruction that occured within AIAB group were more successful than those that occured in the artery and nerve-grafting groups.

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References

  1. Agnati LF, Zini I, Zali M (1988) Regeneration in the CNS: concepts and facts. In: Symon Let al (eds) Advances and technical standards in neurosurgery, Vol 16. Springer, Wien New York, pp 3–82

    Google Scholar 

  2. Aguayo AJ, Bray GM (1984) Cell interactions studied in the peripheral nerves of experimental animals. In: Dych PJet al (eds) Peripheral neuropathy, Vol 1, 2nd Ed. Saunders, Philadelphia, pp 39–96

    Google Scholar 

  3. Anderson PN, Turmain M (1986) Axonal regeneration through arterial grafts. J Anat 147: 73–82

    PubMed  Google Scholar 

  4. Bratton BR, Kline DG, Coleman W, Hudson AR (1979) Experimental interfascicular nerve grafting. J Neurosurg 51: 323–332

    PubMed  Google Scholar 

  5. Brunelli G, Brunelli F (1990) Strategy and timing of peripheral nerve surgery. Neurosurg Rev 13: 95–102

    PubMed  Google Scholar 

  6. Büngner OW (1891) Die Degenerations- und Regenerationsvorgänge an Nerven nach Verletzungen. Beitr Pathol Anat 10: 321–393

    Google Scholar 

  7. Chiu DTW, Janecka I, Krizek TJ, Wolff M, Lovelace RE (1982) Autogenous vein graft as a conduit for nerve regeneration. Surgery 91: 226–233

    PubMed  Google Scholar 

  8. Dahlin LB, Danielsen N, Ochi M, Lundborg G (1988) Axonal growth in mesothelial chambers: effects of a proximal preconditions lesion and/or predegeneration of the distal nerve stump. Exp Neurol 99: 655–663

    PubMed  Google Scholar 

  9. Danielsen N, Vahlsing HL, Manthorpe M, Varon S (1988) A two compartment modification of the silicone chamber model for nerve regeneration. Exp Neurol 98: 622–635

    Google Scholar 

  10. Eden R (1916) Untersuchungen über die spontane Wiedervereinigung durchtrennter Nerven im strömenden Blut und im leeren Gefäßrohr. Arch Klin Chir 108: 344–357

    Google Scholar 

  11. Fawcett JW, Keynes RJ (1990) Peripheral nervel regeneration. Ann Rev Neurosci 13: 43–60

    PubMed  Google Scholar 

  12. Fernandez E, Pallini R, Mercenti D (1990) Effects of topically administrated nerve growth factor on axonal regeneration in peripheral nerve autografts implanted in the spinal cord of rats. Neurosurgery 26: 37–42

    PubMed  Google Scholar 

  13. Foramitti C (1904) Zur Technik der Nervennaht. Arch Klin Chir 73: 643–648

    Google Scholar 

  14. Glosby MA, Gschmeissner SE, Huang CL-H, Pisouza PA (1986) Degenerated muscle grafts used for peripheral nerve repair in primates. J Hand Surg 11-B: 347–351

    Google Scholar 

  15. Gluck T (1880) Ueber Neuroplastik auf dem Wege der Transplantation. Arch Klin Chir 25: 606–616

    Google Scholar 

  16. Godard J, Coulon G, Monnier G, Rouillon D, Jacquet G, Bourghli A, Steimle R (1984) Regenerescence nerveuse à transverse un greffon veineux chez le rat. Neurochirurgie 30: 407–416

    PubMed  Google Scholar 

  17. Gospodorowicz D, III C (1980) Extracellular matrix and control of proliferation of vascular endothelial cells. J Clin Invest 65: 1351–1364

    PubMed  Google Scholar 

  18. Gulati AK (1989) Axon regeneration through blood vessel allografts after cyclosporine treatment. J Neurosurg 70: 115–120

    PubMed  Google Scholar 

  19. Hall SM (1989) Regeneration in the peripheral nervous system. Neuropathol Appl Neurobioll 5: 513–529

    Google Scholar 

  20. Henry EW, Chiu TH, Nyilas E (1985) Nerve regeneration through biodegradable polyester tubes. Exp Neurol 90: 652–676

    PubMed  Google Scholar 

  21. Jaffe EA, Mosher DF (1978) Synthesis of fibronectin by cultured human endothelial cells. J Exp Med 147: 1779–1791

    PubMed  Google Scholar 

  22. Jenq CB, Coggeshall RE (1985) Nerve regeneration through holey silicone tubes. Brain Res 361: 233–241

    PubMed  Google Scholar 

  23. Jenq CB, Coggeshall RE (1986) Regeneration of transected rat sciatic nerves after using isolated nerve as distal inserts in silicone tubes. Exp Neurol 91: 154–162

    PubMed  Google Scholar 

  24. Jenq CB, Jenq LL, Coggeshall RE (1987) Nerve regeneration changes with filters of different pore size. Exp Neurol 97: 662–671

    PubMed  Google Scholar 

  25. Kosaka M (1990) Enhancement of rat peripheral nerve regeneration through artery-including silicone tubing. Exp Neurol 107: 69–77

    PubMed  Google Scholar 

  26. Longo FM, Manthorpe M, Skaper SD (1983) Neuronotrophic activities occumulate in vivo within silicone nerve regeneration chambers. Brain Res 261: 109–117

    PubMed  Google Scholar 

  27. Lundborg G, Hansson HD (1979) Regeneration of peripheral nerve through a preformed tissue space: preliminary observations on the reorganization of regenerating nerve fibres and perineurium. Brain Res 179: 573–576

    Google Scholar 

  28. Lundborg G, Longo FM, Varon S (1982) Nerve regeneration model and trophic factors in vivo. Brain Res 232: 157–161

    PubMed  Google Scholar 

  29. Lundborg G (1987) Nerve regeneration and repair: a review. Acta Ortop Scand 58: 145–169

    Google Scholar 

  30. MacKinnon SE, Dellon AL, Hudson AR, Hunter DA (1985) Nerve regeneration through a pseudosynovial sheath in a primate model. Plast Reconst Surg 75: 833–839

    PubMed  Google Scholar 

  31. Nageotte J (1915) Le processus de la cicatrisation des nerfs. CR Soc Biol 78: 249–254

    Google Scholar 

  32. Risitano G, Covallaro G, Lentini M (1989) Autogenous vein and nerve grafts: a comperative study of nerve regeneration in the rat. J Hand Surg 14B: 102–104

    Google Scholar 

  33. Seckel BR, Ryan SE, Gagne RG (1986) Target-specific nerve regeneration through a nerve guide in the rat. Plast Reconst Surg 78: 793–798

    PubMed  Google Scholar 

  34. Seckel BR (1990) Enhancement of peripheral nerve regeneration. Muscle Nerve 13: 788–800

    Google Scholar 

  35. Suematsu N (1988) Vein graft for repair of peripheral nerve gap. J Reconst Microsurg 4: 313–318

    Google Scholar 

  36. Suematsu N (1989) Tubulation for peripheral nerve gap: its history and possibility. Microsurgery 10: 71–74

    PubMed  Google Scholar 

  37. Swan JJ (1914) Discussion on injuries to the peripheral nerves. Proc R Soc Med 34: 521–532

    Google Scholar 

  38. Vanlair C (1882) De la régénération des nerfs périphériques par le procède de la suture tubulair. CR Acad Sci (Paris) 65: 99–101

    Google Scholar 

  39. Weiss P (1944) The technology of nerve regeneration: a review. Sutureless tubulation and related methods of nerve repair. J Neurosurg 1: 400–450

    Google Scholar 

  40. Weiss P, Taylor AC (1944) Further experimental evidence against “neurotropism” in nerve regeneration. J Exp Zool 95: 233–257

    Google Scholar 

  41. Wrede L (1909) Ueberbrueckung eines Nervendefektes mittels Seidennaht und lebenden Venenstueckes. Dtsch Med Wschr 35: 1125

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurosurgery, Hacettepe University Medical School, Ankara, Turkey

    O. Çataltepe, O. E. Özcan & A. Erbengi

  2. Department of Pharmacology, Hacettepe University Medical School, Ankara, Turkey

    R. Onur

  3. Department of Pathology, Hacettepe University Medical School, Ankara, Turkey

    B. Demirhan & Ş. Ruacan

Authors
  1. O. Çataltepe
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  2. O. E. Özcan
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  3. R. Onur
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  4. B. Demirhan
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  5. Ş. Ruacan
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  6. A. Erbengi
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Çataltepe, O., Özcan, O.E., Onur, R. et al. Arterial bridging for repair of peripheral nerve gap: a comparative study. Acta neurochir 121, 181–186 (1993). https://doi.org/10.1007/BF01809272

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