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Contemporaneous bilateral postero-ventral pallidotomy for early onset “juvenile type” Parkinson's disease. Case report

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Summary

Early onset “juvenile type” Parkinson's disease is commonly associated with disabling bilateral levodopa-induced dyskinesias. We report here a successful contemporaneous bilateral postero-ventral pallidotomy performed on a 46-year-old male with juvenile type Parkinson's and associated levodopa incited symmetric dyskinesias. A comparison of various surgical alternatives is included. Preoperative and postoperative evaluation, operative method and postero-ventral pallidotomy's therapeutic mechanism are presented.

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References

  1. Aziz TZ, Peggs D, Agarwal E, Sambrook MA, Crossman AR (1992) Subthalamic nucleotomy alleviates parkinsonism in the 1-methly-4-phenyl-1,2,3,6-tetrahydrophyridine (MPTP)-exposed monkey. Br J Neurosurg 6: 575–582

    PubMed  Google Scholar 

  2. Brotchie JM, Mitchell IJ, Sambrook MA, Crossman AR (1991) Alleviation of Parkinsonism by antagonism of excitatory amino acid transmission in the medial segment of the globus pallidus in rat and primate. Mov Disord 6: 133–138

    PubMed  Google Scholar 

  3. Bergman H, Wichmann T, DeLong MR (1990) Reversal of experimental Parkinsonism by lesions of the subthalamic nucleus. Science 249: 1436–1438

    PubMed  Google Scholar 

  4. Caparros-Lefebvre, Blond S, Vermersch P, Peckeux N, Guieu JD, Petit H (1993) Chronic thalamic stimulation improves tremor and levodopa induced dyskinesias in Parkinson's disease. J Neurol Neurosurg Psychiatry 56: 268–273

    PubMed  Google Scholar 

  5. Carpenter MB (1991) Core test of neuroanatomy, 4th Ed. Williams and Wilkins, Baltimore, p 346

    Google Scholar 

  6. Crossman AR, Jackson A (1983) Nucleus tegmenti pedunculopontinus: efferent connections with special reference to the basal ganglia, studied in the rat by anterograde and retrograde transport of horseradish peroxidase. Neuroscience 10: 725–765

    PubMed  Google Scholar 

  7. DeVito JL, Anderson ME (1982) An autoradiographic study of efferent connections of the globus pallidus in macaca mulatta. Exper Brain Res 46: 107–117

    Google Scholar 

  8. Freed CR, Breeze RE, Rosenberg NL, Schneck SA, Kriek E, Qi J, Lone T, Zhang Y, Snyder JA, Wells T, Ramig LO, Thompson L, Mazziotta JC, Huang SC, Grafton ST, Brooks D, Sawle G, Schroter G, Ansari AA (1992) Survival of implanted fetal dopamine cells and neurologic improvement 12 to 46 months after transplantation for Parkinson's disease. N Engl J Med 327: 1549–1555

    PubMed  Google Scholar 

  9. Freed CR (1988) Transplantation of fetal substantia nigra and adrenal medulla to the caudate nucleus in two patients with Parkinson's disease. N Engl J Med 319: 370–371

    PubMed  Google Scholar 

  10. Gershanik OS (1993) Early-onset Parkinsonism. In: Jankovic J, Tolosa E (eds) Parkinson's disease and movement disorders, 2nd Ed. Williams and Wilkins, Baltimore, pp235–252

    Google Scholar 

  11. Goetz GC, Olanow W, Koller WC, Penn RD, Cahill D, Morantz R, Stebbins F, Tanner CM, Klawans HL, Shannon KM, Waxman M, Gauger L (1989) Multicenter study of autologous adrenal medullary transplantation to the corpus striatum in patients with advanced Parkinson's disease. N Engl J Med 320: 337–341

    PubMed  Google Scholar 

  12. Guridi J, Luguin MR, Herrero MT, Guillen J, Obeso JA (1993) Antiparkinsonian effect of subthalamotomy in MPTP-exposed monkeys. Mov Disord 8: 415

    Google Scholar 

  13. Hammond C, Rouzaire-Dubois B, Feger J, Jackson A, Crossman AR (1983) Anatomical and electrophysiological studies on the reciprocal projections between the subthalamic nucleus and nucleus tegmenti pedunculopontinus in the rat. Neuroscience 9: 41–52

    PubMed  Google Scholar 

  14. Hirsch EC, Duyckaerts C, Javoy-Agid F, Hauw JJ, Agid Y (1990) Does adrenal graft enhance recovery of dopaminergic neurons in Parkinson's disease? Ann Neurol 27: 676–682

    PubMed  Google Scholar 

  15. Iacono RP, Nashold BS Jr (1991) Stereotactic neurosurgery. In: Sabiston DC (ed) Textbook of surgery. The biological basis of modern surgical practice, 14th Ed. Saunders, Philadelphia, pp1287–1290

    Google Scholar 

  16. Iacono RP, Shima F (1994) Deep brain stimulation of the internal globus pallidum in Parkinson's disease. Presented at the 1994 AANS Annual Meeting San Diego, CA, April 1994

  17. Iacono PR, Shima F, Tang AZ, Yamada S (1993) Culminating improvements of fetal graft vs P-V pallidotomy for movement disorders. World Society for Stereotactic and Functional Neurosurgery, Istapa, Mexico, October 1993

  18. Kim R, Nakano K, Jayaraman A, Carpenter MB: Projections of the globus pallidus and adjacent structures: an autoradiographic study in the monkey. J Comp Neurol 169: 263–290

  19. Laitinen LV, Hariz MI (1990) Pallidal surgery abolishes all Parkinsonian symptoms. Mov Disord 5: 82

    Google Scholar 

  20. Laitinen LV, Bergenheim AT, Hariz MI (1992) Leksell's posteroventral pallidotomy in the treatment of Parkinson's disease. J Neurosurg 76: 53–61

    PubMed  Google Scholar 

  21. Lang AE (1990) Clinical rating scales and videotape analysis. In: Koller WC, Parlson G (ed) Therapy of Parkinson's disease. Marcel Dekker, New York

    Google Scholar 

  22. Lieberman A, Ranssohoff J, Berczeller P, Brous P, Eng K, Goldstein M, Daufman B, Koslow M (1988) Neural and adrenal medullary transplants as a treatment for Parkinson's disease and other neurodegenerative disorders. Neuro view trends. Clin Neurol 4: 1–14

    Google Scholar 

  23. Milner KL, Mogenson GJ (1988) Electrical and chemical activation of the mesencephalic and subthalamic locomotor regions in freely moving rats. Brain Res 452: 273–285

    PubMed  Google Scholar 

  24. Narabayashi H (1990) Surgical treatment in the levodopa era. In: Stern G (ed) Parkinson's disease. Chapman and Hall, London, pp597–646

    Google Scholar 

  25. Narabayashi H (1962) Neurophysiological ideas on pallidotomy and ventrolateral thalamotomy for hyperkinesis. 1st Int Symp Stereoencephalotomy, Philadelphia 1961. Confin Neurol 22: 291–303

    PubMed  Google Scholar 

  26. Pallis CA (1971) Parkinsonism: natural history and clinical feature. BMS 3: 683–690

    Google Scholar 

  27. Pantelatos A, Fornadi F (1993) Clinical features medical treatment of Parkinson's disease in patient groups selected in accordance with age at onset. Adv Neurol 60: 690–697

    PubMed  Google Scholar 

  28. Parent A, Smith Y (1987) Organization of efferent projections of the subthalamic nucleus in the squirrel monkey as revealed by retrograde labeling methods. Brain Res 436: 296–310

    PubMed  Google Scholar 

  29. Peppe A, Dambrosia J, Chase T (1993) Risk factors for motor response complications in L-DOPA-treated parkinsonian patients. Adv Neurol 60: 698–702

    PubMed  Google Scholar 

  30. Percheron G, Filion M, Tremblay L, Fenelon G, Francois C, Yelnik J (1993) The role of the medical pallidum in the pathophysiology of akinesia in primates. Adv Neurol 60: 84–87

    PubMed  Google Scholar 

  31. Robertson RG, Clarke CA, Boyce S, Sambrook MA, Crossman AR (1990) The role of striatopallidal neurones utilizing gamma-aminobutyric acid of the pathophysiology of MPTP-induced parkinsonism in the primate: evidence from [3H]flunitrazepam autoradiography. Brain Res 531: 95–104

    PubMed  Google Scholar 

  32. Sandyk R, Iacono RP (1988) The relationship of the reticular system to the primary pathoetiology of Parkinson's disease. Int J Neuroscience 42: 297–300

    Google Scholar 

  33. Sandyk R, Iacono R (1989) Non-dopaminergic mechanisms in adrenal medullary transplantation for Parkinson's disease. Int J Neurosci 45: 259–260

    PubMed  Google Scholar 

  34. Scarnati E, Campana E, Pacitti C (1984) Pedunculopontine-evoked excitation of substantia nigra neurons in the rat. Brain Res 304: 351–361

    PubMed  Google Scholar 

  35. Spencer DD, Robbins RJ, Naftolin F, Phil D, Marek KL, Vollmer T, Leranth C, Roth RH, Price LH, Gjedde A, Bunney BS, Sass KJ, Elsworth JD, Kier L, Makuch R, Hoffer PB, Redmond DE (1992) Unilateral transplantation of human fetal mesencephalic tissue into the caudate nucleus of patients with Parkinson's disease. N Engl J Med 327: 1541–1548

    PubMed  Google Scholar 

  36. Svennilson E, Torvik A, Lowe R, Leksell L (1960) Treatment of Parkinsonism by stereotactic thermolesions in paludal region. Psychiatr Neurol Scand 35: 358–377

    Google Scholar 

  37. Wichmann T, DeLong M (1993) Pathophysiology of Parkinsonian motor abnormalities. Adv Neurol 60: 5360

    Google Scholar 

  38. Widner H, Tetrud J, Rehncrona S, Snow B, Brundin P, Custavii B, Bjorklund A, Lindvall O, Langston W (1992) Bilateral fetal mesencephalic grafting in two patients with parkinsonism induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydrophydridine. N Engl J Med: 1556

  39. Widner H, Tetrud J, Rehncrona S,et al (1993) Fifteen months follow-up on bilateral embryonic mesencephalic grafts in two cases of severe MPTP-induced parkinsonism. Adv Neurol 60: 729–733

    PubMed  Google Scholar 

  40. Zweig RM, Jankel WR, Hedreen JC, Mayeux R, Price DL (1989) The pedunculopontine nucleus in Parkinson's disease. Am Neurol Assoc 26: 41–46

    Google Scholar 

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Iacono, R.P., Lonser, R.R. & Yamada, S. Contemporaneous bilateral postero-ventral pallidotomy for early onset “juvenile type” Parkinson's disease. Case report. Acta neurochir 131, 247–252 (1994). https://doi.org/10.1007/BF01808622

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