Abstract
An intramolecular mutual activation between a phosphoryl group and carboxyl group results in the simultaneous formation of nucleotides and peptides by the reaction of nucleosides with N-(O,O-diisopropyl)phosphothreonine in anhydrous pyridine. These results suggest pathways for the simultaneous prebiotic synthesis of peptides and oligonucleotides.
Article PDF
Similar content being viewed by others
References
Cech, T. R., Zaug, A. T. and Grabowski, P. J.: 1981,Cell 27, 487–496.
Crik, F. H. C.: 1968,J. Mol. Biol. 38, 367.
Dai, X., Mesmaeker, A. D. and Joyce, G. F.: 1995,Science, 237–239.
Dunn, D. B. and Hall, R. H.: 1975,CRC Handbook of Biochemistry and Molecular Biology, CRC press, Cleveland, p. 65.
Fox, S. W. and Dose, K.: 1977,Molecular Evolution and the Origins of Life, 2nd, Marcel Dekker, New York.
Herschlag, D. and Cech, T. R.: 1990,Nature 344, 405–409.
Hulshof, J. and Ponamperuma: 1976,Orig. Life. Evol. Biosphere 7, 197.
Ji, G. J., Xue, C. B., Zeng, J. N., Li, L. P., Chai, W. G. and Zhao, Y. F.: 1988,Synthesis 6, 444.
Ju, Y., Zhao, Y. F., Sha, Y. W. and Tan, B.: 1995,Phosphorus Sulfur Silicon 101, 117.
Kovacs, J. and Nagy, H.: 1961,Nature 19, 531.
Li, Y. M., Yin, Y. W. and Zhao, Y. F.: 1992a,Int. J. Peptide Protein Res. 39, 375.
Li, Y. M., Zhang, D. Q., Zhang, H. W., Ji, G. J. and Zhao, Y. F.: 1992b,Bioorganic Chemistry 20, 285–295.
Miller, S. L. and Orgel, L. E.: 1974,The Origins of Life on the Earth, Prentice Hall Inc., Englewood Cliffs, New Jersey, U.S.A.
Morl, M., Niemer, I. and Schmeltzer, C.: 1992,Cell 70, 803–810.
Noller, H. F., Hoffarth, V. and Zimniak, L.: 1992,Science 256, 1416–1419.
Orgel, L. E.: 1968,J. Mol. Biol. 38, 381.
Rich, A.: 1962, M. Kasha and B. Pullman (eds.),Horizons in Biochemistry, Academic Press, p. 103.
Rolfing, D. L. and Fox, S. W.: 1969,Advances in Catalysis 20, 373.
Tan, B. and Zhao, Y. F.: 1995,Chinese Youji Huaxue 15, 30–34.
Wang, Q., Zhao, Y. F., An, F. L., Wang, Q. Z. and Mao, Y. Q.: 1995,Science in China (Series B) 25(7), 683–689.
Xue, C. B., Yin, Y. W. and Zhao, Y. F.: 1988,Tetrahedron Lett. 29, 1145–1148.
Yang, H. J., He, M. Y., Ye, Y. H. and Zhao, Y. F.: 1992,Org. Mass Spectrometry 27, 746–749.
Yin, Y. W., Ma, Y., Zhao, Y. F., Li, Y. F., Feng, Y. P. and Mao, Y. Q.: 1995,Science in China (Series B) 25(5), 472–479.
Yin, Y. W., Zhang, B. Z., Chen, Y. and Zhao, Y. F.: 1994,Chinese Kexue Tongbao 39, 333.
Yin, Y. W., Zhao, Y. F., Chen, Y., Ma, Y., In, B. and Wang, G. H.: 1994,Science in China (Series B) 24(9), 904–913cccc.
Zhao, Y. F., Ju, Y., Li, Y. M., Wang, Q., Yin, Y. W. and Tan, B.: 1995,Int. J. Peptide Protein Res. 45, 514–518.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Zhou, W., Ju, Y., Zhao, Y. et al. Simultaneous formation of peptides and nucleotides from n-phosphothreonine. Origins Life Evol Biosphere 26, 547–560 (1996). https://doi.org/10.1007/BF01808220
Received:
Issue Date:
DOI: https://doi.org/10.1007/BF01808220