Abstract
Treatment of relatively concentrated aqueous solutions of O-phospho-serine (50 mM), aspartic acid (100 mM) or glutamic acid (100 mM) with carbonyldiimidazole leads to the formation of an activated intermediate that oligomerizes efficiently. When the concentration of amino acid is reduced tenfold, few long oligomers can be detected. Positively-charged cetyltrimethyl ammonium bromide micelles concentrate the negatively-charged activated intermediates of the amino acids at their surfaces and catalyze efficient oligomerization even from dilute solutions.
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Armstrong, D. W., Seguin, R., McNeal, C. J., Macfarlane, R. D. and Fendler, J. H.: 1978,J. Am. Chem. Soc. 100, 4605–4606.
Broxton, T. J. and Lucas, M.: 1994,J. Phys. Org. Chem. 7, 442–447.
Ehler, K. W.: 1976,J. Org. Chem. 41, 3041–3042.
Ehler, K. W., Girard, E. and Orgel, L. E.: 1977,Biochim. Biophys. Acta 491, 253–264.
Ehler, K. W. and Orgel, L. E.: 1976,Biochim. Biophys. Acta 434, 233–243.
Engbersen, J. F. J., Koudijs, A. and Vanderplas, H. C.: 1990,J. Mol. Cat. 57, 417–426.
Fendler, J. H. and Fendler, E. J.: 1975,Catalysis in Micellar and Macromolecular systems. Academic Press, New York.
Joyce, G. F., Inoue, T. and Orgel, L. E.: 1984,J. Mol. Biol. 176, 279–306.
Menger, F. M.: 1991,Angew. Chem. 103, 1104–1118.
Menger, F. M. and Fei, Z. X.: 1994,Angew. Chem. 33, 346–348.
Oparin, A. I.: 1924, Proischogdenie Zhizni. Translation in J.D. Bernal (1967) “The Origin of Life”, London, Weidenfeld and Nicolson; World Publishing Co., New York. Moscovsky Robotchii, Moscow.
Panigrahi, G. P. and Mishra, S. K.: 1993,J. Mol. Cat. 81, 349–362.
Patel, M. S., Bijma, K. and Engberts, J. B. F. N.: 1994,Langmuir 10, 2491–2492.
Zieboll, G. and Orgel, L. E.: 1994,J. Mol. Evol. 38, 561–565.
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Böhler, C., Hill, A.R. & Orgel, L.E. Catalysis of the oligomerization of O-phospho-serine, aspartic acid, or glutamic acid by cationic micelles. Origins Life Evol Biosphere 26, 1–5 (1996). https://doi.org/10.1007/BF01808155
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DOI: https://doi.org/10.1007/BF01808155