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A phase I study of toremifene

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Abstract

A Phase I study of the new antiestrogenic drug toremifene was carried out in 27 Japanese women, using oral doses of 10–480 mg per day for one or five days. Serum concentrations reached a dose-dependent maximum 2–6 hours after each oral administration. Side effects were generally mild.

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References

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Authors and Affiliations

  1. Dept. of Surgery, Tokyo Metropolitan Komagome Hospital, 18-22 Honkomagome 3-chome, Bunkyo-ku, 113, Tokyo, Japan

    Takeshi Tominaga

  2. Keio University, Tokyo, Japan

    Osahiko Abe

  3. Gunma University, Maebashi, Japan

    Masuru Izuo

  4. National Kyushu Cancer Center Hospital, Fukuoka, Japan

    Yasuo Nomura

Authors
  1. Takeshi Tominaga
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  2. Osahiko Abe
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  3. Masuru Izuo
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  4. Yasuo Nomura
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Tominaga, T., Abe, O., Izuo, M. et al. A phase I study of toremifene. Breast Cancer Res Tr 16 (Suppl 1), S (1990). https://doi.org/10.1007/BF01807141

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  • DOI: https://doi.org/10.1007/BF01807141

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