Abstract
Wearing a special thermometric brassiere, selected women self-measured their breast surface temperature. These measurements were made during one hour each evening at home for one menstrual cycle under standard conditions of overclothing and room temperature. To stage their cycle they also collected daily samples of saliva in their freezer for immuno-assay of progesterone concentration in the laboratory. A total of 82 women participated, most having young families. This total included four groups, a control group (N = 25) and three ‘disease’ groups, namely: family history of breast cancer (14); benign breast disease (12); and a ‘cancer-associated’ group (31) who had had previous cancer surgery. A significant breast temperature rhythm with a period at or about 28 days was found not only in the controls but also in the three groups of breasts designated ‘disease’. Nevertheless, consistent rhythm abnormalities were found in all the disease groups. Most evident was a hyperthermia throughout the cycle, a reduction in the rhythm amplitude, and a tendency for the breast temperature rhythm to be manifest 1–2 days earlier in the menstrual cycle.
References
Simpson HW, Griffiths K, McArdle C, Pauson AW, Hume P, Turkes A: The luteal heat cycle of the breast in health. Breast Cancer Res Treat 27: 239–245, 1993
Gillis CR: Personal communication. West of Scotland Cancer Surveillance Unit, 1994.
Wang DW, Fentiman IS: Epidemiology and endocrinology of benign breast disease. Breast Cancer Res Treat 6: 5–36, 1985
Adami HO, Hansen J, Jung BO, Rimsten A: Characteristics of familial breast cancer in Sweden. Cancer 48: 1688–1695, 1981
Brinton LA, Hoover R, Fraumeni JF: Interaction of familial and hormonal risk factors for breast cancer. J Natl Cancer Inst 69: 817–822, 1982
Simpson HW, Griffiths K: The diagnosis of breast pre-cancer by the Chronobra. Chronobiol Internat 4: 355–393, 1989
Monson RR, Yen S, MacMahon B, Warren S: Chronic mastitis and carcinoma of the breast. Lancet ii: 224–226, 1976
Jensen HM, Rice JR, Wellings SR: Preneoplastic lesions in the human breast. Science 191: 295–297, 1976
Chaudary MA, Millis RR, Hoskins EOL, Halder M, Bulbrook RD, Cuzick J, Hayward JL: Bilateral primary breast cancer; a prospective study of disease incidence. Br J Surg 71: 711–714, 1984
Eremin O: Second primary breast cancer. Brit Med J 296: 1755, 1988
Griffiths K, Reid GF, Wilson DW, Fahmy DR: Breast cancer research: a new approach through assays for steroids in saliva. Rev Endocrine Related Cancer Suppl 13: 45–53, 1984
Reid GF, Bradley JA, Wilson DW, George WD, Griffiths K: Evaluation of luteal phase salivary progesterone levels in women with benign breast disease. Eur J Cancer Clin Oncol 21: 9–17, 1985
Presser HB: Temporal data relating to the human menstrual cycle. In: Ferin M, Halberg F, Richart RM, Vanden Wiele RL (eds) Biorhythms and Human Reproduction, Chapter 10. John Wiley, New York, 1974, p 158
Halberg F, Johnson EA, Nelson W, Runge W, Sothern R: Autorhythmometry procedures for physiological measurements and their analysis. The Physiology Teacher 1: 4,1–11, 1972. Published by the American Physiology Society
Matsumoto S, Nogami Y, Ohkuri S, Gunma J: Med Sci 11: 294, 1962, cited by Presser (see above)
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These data have been presented to the President Clinton's Cancer Panel's Special Commission on Breast Cancer, Miami, March 1993
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Simpson, H.W., Griffiths, K., McArdle, C. et al. The luteal heat cycle of the breast in disease. Breast Cancer Res Tr 37, 169–178 (1996). https://doi.org/10.1007/BF01806498
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DOI: https://doi.org/10.1007/BF01806498