Summary
A multi-institutional randomized clinical trial was carried out to evaluate the effect of vincristine (V) added to cyclophosphamide, methotrexate, 5-fluorouracil, and prednisone (CMFP) for the treatment of metastatic breast cancer. There were 427 patients entered into the study and randomly assigned to one of the two treatments, i.e. the five drug therapy CMFPV or the four drug therapy CMFP. The differences in patient survival and tumor response between the two treatment groups were not statistically significant. The data were also analyzed using multivariate procedures to determine those factors ascertained at entry into the study which were predictors of survival or predictors of response to therapy. The one factor that predicted both response and survival was performance status. An additional important predictor of survival was sites of metastatic involvement. Other significant predictors of response were menopausal age, BUN, and hematocrit.
References
Greenspan EM: Combination cytotoxic chemotherapy in advanced disseminated breast carcinoma. J Mt Sinai Hosp 33: 1–17, 1966
Cooper RG: Combination chemotherapy in hormone resistant breast cancer (Abstract). Proc AACR 10: 15, 1969
Ansfield FJ, Ramirez E, Korbits BC, Davis jr AL: Fivedrug therapy for advanced breast cancer: a phase I study. Cancer Chemother Rep 55: 183–187, 1971
Carter SK: Single and combination nonhormone chemotherapy in breast cancer. Cancer 30: 1543–1555, 1972
Segaloff A: Assessment of response to treatment by the Co-operative Breast Cancer Group. In: JL Hayward, RO Bulbrook (eds): Clinical Evaluation of Breast Cancer. Academic Press, London, 1966, pp 125–130
Culter SJ and Ederer F: Maximum utilization of the life table method in analyzing survival. J Chron Dis 8: 699–712, 1958
Mantel N: Evaluation of survival data and two new rank order statistics arising in its consideration. Cancer Chemother Rep 50: 163–169, 1966
Snedecor GW, Cochran WG: Statistical Methods (Sixth Edition). The Iowa State University Press, Ames, Iowa, 1967, pp 217
Snedecor GW, Cochran WG: Statistical Methods (Sixth Edition). The Iowa State University Press, Ames, Iowa, 1967, pp 246–250
Cox DR: Regression models and life tables (with discussion). J Roy Stat Soc (B) 34: 187–220, 1972
Walker SH, Duncan DB: Estimation of the probability of an event as a function of several independent variables. Biometrika 54: 167–179, 1967
Mantel N: Why stepdown procedures in variable selection. Technometrics 12: 621–625, 1970
Ahmann DL, Bisel HF, Hahn RG, Eagan RT, Edmonson JH, Steinfeld JL, Tormey DC, Taylor WF: An analysis of a multiple-drug program in the treatment of patients with advanced breast cancer utilizing 5-fluorouracil, cyclophosphamide, and prednisone with or without vincristine. Cancer 36: 1925–1935, 1975
Rainey JM, Jones SE, Salmon SE: Combination chemotherapy for advanced breast cancer utilizing vincristine, adriamycin, and cyclophosphamide (VAC). Cancer 43: 66–71, 1979
Steiner R, Stewart JF, Cantwell BMJ, Minton MJ, Knight RK, Rubens RD: Adriamycin alone or combined with vincristine in the treatment of advanced breast cancer. Eur J Cancer Clin Oncol 19: 1553–1557, 1983
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Deceased, February, 1985
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Segaloff, A., Hankey, B.F., Carter, A.C. et al. An evaluation of the effect of vincristine added to cyclophosphamide, 5-fluorouracil, methotrexate, and prednisone in advanced breast cancer. Breast Cancer Res Tr 5, 311–319 (1985). https://doi.org/10.1007/BF01806026
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DOI: https://doi.org/10.1007/BF01806026