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References
Abita, J.-P., Dorche, C. and Kaufman, S. (1974). Further studies on the nature of phenylalanine hydroxylation in brain.Pediatr. Res.,8, 714
Abita, J.-P., Milstein, S., Chang, N. and Kaufman, S. (1976).In vitro activation of rat liver phenylalanine hydroxylase by phosphorylation.J. Biol. Chem.,251, 5310
Cheema, S., Soldin, S. J., Knapp, A., Hofmann, T. and Scrimgeour, K. G. (1973). Properties of purified quinonoid dihydropterin reductase.Can. J. Biochem.,51, 1229
Craine, J. E., Hall, E. S. and Kaufman, S. (1972). The isolation and characterization of dihydropteridine reductase from sheep liver.J. Biol. Chem.,247, 6082
Fisher, D. B., Kirkwood, R. and Kaufman, S. (1972). Rat liver phenylalanine hydroxylase, an iron enzyme.J. Biol. Chem.,247, 5161
Friedman, P. A., Kappelman, A. H. and Kaufman, S. (1972). Partial purification and characterization of tryptophan hydroxylase from rabbit hindbrain.J. Biol. Chem.,247, 4165
Friedman, P. A., Fisher, D. B., Kang, E. S. and Kaufman, S. (1973). Detection of hepatic 4-phenylalanine hydroxylase in classical phenylketonuria.Proc. Natl. Acad. Sci. USA,70, 552
Kaufman, S. (1959). Studies on the mechanism of the enzymatic conversion of phenylalanine to tyrosine.J. Biol. Chem.,234, 2677
Kaufman, S. (1973). The structure of phenylalanine hydroxylation cofactor.Proc. Natl. Acad. Sci. USA,50, 1085
Kaufman, S. (1964). Further studies on the structure of the primary oxidation product formed from tetrahydropteridines during phenylalanine hydroxylation.J. Biol. Chem.,239, 332
Kaufman, S. (1967a). Metabolism of the phenylalanine hydroxylation cofactor.J. Biol. Chem.,242, 3934
Kaufman, S. (1967b). Pteridine cofactors.Ann. Rev. Biochem.,36, 171
Kaufman, S. (1969). Phenylalanine hydroxylase of human liver: assay and some properties.Arch. Biochem. Biophys.,134, 249
Kaufman, S. (1971). The phenylalanine hydroxylating system from mammalian liver.Adv. Enzymol.,35, 245
Kaufman, S. (1976). Phenylketonuria: biochemical mechanisms. In:Advances in Neurochemistry (B. W. Agranoff and M. H. Aprison, eds), p. 1. New York: Plenum Press
Kaufman, S. and Fisher, D. B. (1970). Purification and some physical properties of phenylalanine hydroxylase from rat liver.J. Biol. Chem.,245, 4745
Kaufman, S. and Fisher, D. B. (1974). Pterin-requiring aromatic amino acid hydroxylases. In:Molecular Mechanisms of Oxygen Activation (O. Hayaishi, ed.), p. 285. New York: Academic Press
Kaufam, S., Holtzman, N. A., Milstein, S., Butler, I. J. and Krumholz, A. (1975). Phenylketonuria due to a deficiency of dihydropteridine reductase.N. Engl. J. Med.,293, 785
Milstein, S., Holtzman, N. A., O'Flynn, M. E., Thomas, G. H., Butler, I. J. and Kaufman, S. (1976). Hyperphenylalaniemia due to dihydropteridine reductase deficiency.J. Pediatr.,89, 763
Nielsen, K. M., Simonsen, V. and Lind, K. E. (1969). Dihydropteridine reductase. A method for the measurement of activity, and investigations of the specificity for NADH and NADPH.Eur. J. Biochem.,9, 497
Wapnir, R. A., Hawkins, R. L. and Stevenson, J. H. (1971). Ontogenesis of phenylalanine and tryptophan hydroxylation in rat brain and liver.Biol. Neonate,118, 85
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Kaufman, S. The enzymes of the hepatic phenylalanine hydroxylating system. J Inherit Metab Dis 1, 63–65 (1978). https://doi.org/10.1007/BF01801846
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DOI: https://doi.org/10.1007/BF01801846