Summary
Allogeneic bone marrow transplantation was performed on twins with Sanfilippo B disease. They were the first two patients with this disorder to undergo the procedure. There was definite evidence of engraftment as shown by conversion to donor blood group antigen and tissue type, and increased leukocyte α-glucosaminidase activity. Nine years post transplant, neither twin is as handicapped as her untreated brothers were at the same age, although in one twin hyperactivity and behavioural problems, characteristic of the disorder, are present. Details of the twins' intellectual development and growth, their α-glucosaminidase activity and urinary glycosaminoglycan excretion are reported.
Similar content being viewed by others
References
Andria G, Di Natale P, Del Giudice E, Strisciuglio P, Murino P (1979) Sanfilippo B syndrome (MPS IIIB): mild and severe forms within the same sibship.Clin Genet 15: 500–504.
Bordigoni P, Vidailbet M, Lena M, Maire I, Gelot S (1989) Bone marrow transplantation for Sanfilippo syndrome. In Hobbs JR, ed.Correction of Certain Genetic Diseases by Transplantation. London: Cogent, 114–119.
Conzelmann E, Sandhoff K (1983) Partial enzyme deficiencies: residual activities and the development of neurological disorders.Dev Neurosci 6: 58–71.
Griffiths R (1970)The Abilities of Young Children. London: Child Development Research Centre.
Hobbs JR, Barrett AJ, Chambers D et al (1981) Reversal of clinical features of Hurler's disease and biochemical improvement after treatment by bone marrow transplantation.Lancet 2: 709–712.
Hobbs JR, Shaw PJ, Hugh-Jones K, Lindsay I, Hancock M (1987) Beneficial effect of pre-transplant splenectomy on displacement bone marrow transplantation for Gaucher's syndrome.Lancet 1: 1111–1115.
Kamp JJP van de, Pelt JF van, Liem KO, Giesberts MAH, Niepoth LTM, Staalman CR (1976) Clinical variability in Sanfilippo B disease: a report on six patients in two related sibships.Clin Genet 10: 279–284.
Neufeld EF, Muenzer J (1989) The mucopolysaccharidoses. In Scriver CR, Beaudet AL, Sly WS, Valle D, eds.The Metabolic Basis of Inherited Disease, 6th edn. McGraw-Hill, New York.
Whiteman P, Young E (1977) The laboratory diagnosis of Sanfilippo disease.Clin Chim Acta 76: 139–147.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vellodi, A., Young, E., New, M. et al. Bone marrow transplantation for Sanfilippo disease type B. J Inherit Metab Dis 15, 911–918 (1992). https://doi.org/10.1007/BF01800232
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01800232