Summary
This review summarizes current knowledge concerning cataract formation. Metabolically induced forms of cataract are discussed, but mainly aspects of cataract formation in older patients are described, especially with respect to lens protein modifications and epidemiological results. In most cases, cataract in older people is a multifactorial process and therefore cataracts appear in a multitude of different morphological types. Only accurate documentation of lens disturbances and the use of reproducible methods can provide more detailed information about the complexity of the disease cataract.
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References
Anthonisen, H. The frequency of diabetic cataract and diabetic glaucoma as compared to the frequency of diabetes in the general population of Denmark.Acta Ophthalmol. (Kbh.) 14 (1936) 150–158
Benedek, G. Theory of transparency of the eye.Appl. Opt. 10 (1971) 459–472
Harding, J.J. and van Heyningen, R. Beer, cigarettes and military work as risk factors for cataract. In Hockwin, O., Sasaki, K. and Leske, M.C. (eds.), Risk factors for cataract development.Dev. Ophthalmol., Karger, Basel, 1989, pp. 13–16
Hiller, R., Giacometti, L. and Yuen, K. Sunlight and cataract: an epidemiological investigation.Am. J. Epidemiol. 105 (1977) 450–459
Hockwin, O., Biochemie des Auges.Klinsche Monatsblätter für Augenheilkunde, Beiheft 107, Enke, Stuttgart, 1985
Hockwin, O., Okamoto, T., Bergeder, H.D., Klein, W., Ferrari, L. and Streit, W. Genesis of cataracts. Cumulative effects of subliminal noxious influences.Ann. Ophthalmol. 1 (1969) 321–325
Hockwin, O., Dragomirescu, V. and Koch, H.R. Spezialkamera für die Augenphotographie.DFG-Mitteilungen 3 (1978) 17–20
Hockwin, O. and Ohrloff, C. Enzymes in normal, ageing, and cataractous lenses. In Bloemendal (ed.),Molecular and Cellular Biology of the Eye Lens, Wiley, New York, 1981, pp. 367–413
Kahn, H.A., Leibowitz, H., Ganley, J.et al. The Framingham eye study. I. Outline and major prevalence findings.Am. J. Epidemiol. 106 (1977) 17
Kinoshita, J.H. Selected topics in ophthalmic biochemistry.Arch. Ophthalmol. 72 (1964) 554–572
Kinoshita, J.H. Cataracts in galactosemia.Invest. Ophthalmol. 4 (1965) 786–799
Klang, G. Measurements and studies of the fluorescence of the human lensin vivo.Acta Ophthalmol. Suppl. 31 (1948) 1–152
Lerman, S. and Borkman, R.F. Spectroscopic evaluation and classification of the normal, ageing, and cataractous lens.Ophthalmic Res. 8 (1976) 335–353
Ohrloff, C., Stoffel, C., Koch, H.R.et al. Experimental cataracts in rat due to tryptophan-free diet.Graefes Arch. Ophthalmol. 205 (1978) 73
Spencer, W.H.Ophthalmic Pathology, Saunders, Philadelphia, 1985
Trokel, S. The physical basis for the transparency of the lens.Invest. Opthalmol. 1 (1962) 493–502
Wegener, A., Münch, C., Byrd, D.J., Jaeger, W., Hockwin, O. and Bours, J. Die Morphologie von Linsenveränderungen bei experimentell phenylketonurischen Ratten mit ohne Tryptophanmangeldiät.Fortschr. Ophthalmol. 81 (1984) 626–628
Zigman, S., Datiles, M. and Torczynski, E. Sunlight and human cataracts.Invest. Ophthalmol. 18 (1979) 462–467
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Schmitt, C., Hockwin, O. The mechanisms of cataract formation. J Inherit Metab Dis 13, 501–508 (1990). https://doi.org/10.1007/BF01799507
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DOI: https://doi.org/10.1007/BF01799507