Abstract
Coronary flow reserve (CFR) improves in most patients immediately following coronary angioplasty (PTCA). The degree of improvement, however, may be variable and its predictive value for a favorable long-term angiographic result is unknown. To evaluate these issues, we used digital subtraction angiography to measure CFR in 15 patients before and immediately after PTCA. Minimum coronary diameter improved and percent diameter stenosis was reduced immediately following PTCA (from 0.75 ± 0.35 mm to 2.19 ± 0.56 mm, and from 74 ± 12% to 27 ± 15%, respectively; p<0.001). While CFR improved in patients immediately following PTCA (from 1.49 ± 0.75 to 2.68 ± 1.73; p<0.05), a substantial variability in CFR measurements (range 0.80 to 8.33) was present. At repeat arteriography 2.9 ± 0.6 months later, 4 patients demonstrated restenosis. Compared with the 11 patients without restenosis, those with restenosis had similar coronary dimensions and CFRs immediately following PTCA. We conclude that coronary flow reserve, determined by digital subtraction angiography, improves in most patients immediately after PTCA but the degree of improvement is variable. Its ability to predict long-term angiographic outcome remains uncertain.
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Zijlstra F, Reiber JC, Juilliere Y, Serruys PW. Normalization of coronary flow reserve by percutaneous transluminal coronary angioplasty. Am J Cardiol 61: 55–60, 1988.
Hodgson JM, Riley RS, Most AS, Williams DO. Assessment of coronary flow reserve using digital angiography before and after successful percutaneous transluminal coronary angioplasty. Am J Cardiol 60: 61–5, 1987.
O'Neill WW, Walton JA, Bates ER, Colfer HT, Aueron FM, LeFree MT, Pitt B, Vogel RA. Criteria for successful coronary angioplasty as assessed by alterations in coronary vasodilatory reserve. J Am Coll Cardiol 3: 1382–90, 1984.
Wilson RF, Johnson MR, Marcus ML, aylward PEG, Skorton DJ, Collins S, White CW. The effect of coronary angioplasty on coronary flow reserve. Circulation 77: 873–85, 1988.
Zijlstra F, den Boer A, Reiber JHC, van Es GA, Lubsen J, and Serruys PW. Assessment of immediate and long term functional results of percutaneous transluminal coronary angioplasty. Circulation 78: 15–24, 1988.
Serruys PW, Reiber JHC, Wijns W, van den Brand M, Kooijman DJ, ten Katen HJ, Hugenholtz PG. Assessment of percutaneous transluminal coronary angioplasty by quantitative coronary angiography: Diameter versus densitometric area measurements. Am J Cardiol 54: 482–8, 1984.
Fleck E, Dacian S, Dirschinger J, Hall D, Rudolph W. Quantitative changes in stenotic coronary artery lesions during follow-up after PTCA (abstr). Circulation 70 (suppl II) II-176, 1984.
Johnson MR, Brayden GP, Ericksen EE, Collins SM, Skorton DJ, Harrison DG, Marcus ML, White CW. Changes in cross-sectional area of the coronary lumen in the six months after angioplasty: A quantitative analysis of the variable response to percutaneous transluminal angioplasty. Circulation 73: 467–75, 1986.
Bove AA, Holmes DR Jr., Owen RM, Bresnahan JF, Reeder GS, Smith HC, Vlietstra RE. Estimation of the effects of angioplasty on coronary stenosis using quantitative video angiography. Cath Cardiovasc Diag 11: 5–16, 1985.
Sanz ML, Mancini J, LeFree MT, Mickelson JK, Starling MR, Vogel RA, Topol EJ. Variability of quantitative digital subtraction coronary angiography before and after percutaneous transluminal coronary angioplasty. Am J Cardiol 60: 55–60, 1987.
Bates ER, Aueron FM, Legrand V, LeFree MT, Mancini GBJ, Hodgson JM, Vogel RA. Comparative long-term effects of coronary artery bypass graft surgery and percutaneous transluminal coronary angioplasty on regional coronary flow reserve. Circulation 72: 833–9, 1985.
Eichhorn EJ, Konstam MA, Salem, DN, Isner JM, Deckelbaum L, Stransky NB, Metherall JA, and Toltzis HI. Dipyridamole thallium-201 imaging pre- and post-coronary angioplasty for assessment of regional myocardial ischemia in humans. Am Heart J 1989; 117: 1203–1209.
Klocke FJ. Measurements of coronary flow reserve: Defining pathophysiology versus making decisions about patient care. Circulation 76: 1183–89, 1987.
Rothman MT, Baim DS, Simpson JB, Harrison DC. Coronary hemodynamics during percutaneous transluminal coronary angioplasty. Am J Cardiol 49: 1615–22, 1982.
LeFree MI, Simon SB, Mancini GBJ, Vogel RA. Digital radiographic assessment of coronary arterial geometric diameter and videodensitometric cross-sectional area. Proc SPIE 626: 334–41, 1986.
Mancini GBJ, Simon SB, McGillem MJ, LeFree MT, Friedman HZ, Vogel RA. Automated quantitative coronary arteriography: Morphologic and physiologic validation in vivo of a rapid digital angiographic method. Circulation 75: 452–60, 1987.
Hodgson JM, Legrand V, Bates ER, Mancini GBJ, Aueron FM, O'Neill WW, Simon SB, Beauman GJ, LeFree MT, Vogel RA. Validation in dogs of a rapid digital angiographic technique to measure relative coronary blood flow during routine cardiac catheterization. Am J Cardiol 55: 188–93, 1985.
Vogel R, LeFree M, Bates E, O'Neill W, Foster R, Kirlin P, Smith D, Pitt B. Application of digital techniques to selective coronary arteriography: Use of myocardial contrast appearance time to measure coronary flow reserve. Am Heart J 107: 153–64, 1984.
Dehmer GJ, Popma JJ, van den Berg EK, Eichhorn EJ, Prewitt JB, Campbell WB, Jennings L, Willerson JT, and Schmitz JM. Reduction in the rate of early restenosis after coronary angioplasty by a diet supplemented with n-3 fatty acids. N Engl J Med 319: 733–740, 1988.
Gruentzig AR, King SB, Schlumpj M, and Siegenthaler W. Long-term follow-up after percutaneous transluminal coronary angioplasty. N Engl J Med 316: 1127–32, 1987.
Arnett EN, Isner JM, Redwood DR, Kent KM, Baker WP, Ackerstein H, Roberts WC. Coronary artery narrowing in coronary heart disease: Comparison of cineangiographic and necropsy findings. Ann Int Med 91: 350–6, 1979.
Grondin CM, Dyrda I, Pasternac A, Campeau L, Bourassa MG, Lesperance J. Discrepancies between cineangiographic and postmortem findings in patients with coronary artery disease and recent myocardial revascularization. Circulation 49: 703–8, 1974.
McPherson DD, Hiratzka LF, Lamberth WC, Brandt B, Hunt M, Kieso RA, Marcus ML, Kerber RE. Delineation of the extent of coronary atherosclerosis by high-frequency epicardial echocardiography. New Engl J Med 316: 304–9, 1987.
Zir LM, Miller SW, Dinsmore RE, Gilbert JP, Harthorne JW. Inter-observer variability in coronary angiography. Circulation 53: 627–32, 1976.
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Popma, J.J., Dehmer, G.J. & Eichhorn, E.J. Variability of coronary flow reserve obtained immediately after coronary angioplasty. Int J Cardiac Imag 6, 31–38 (1990). https://doi.org/10.1007/BF01798430
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DOI: https://doi.org/10.1007/BF01798430