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Tumor cytotoxicity and interleukin 1 production of blood monocytes of lung cancer patients

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Summary

The effects of lung cancer on the abilities of blood monocytes to produce interleukin-1 and to mediate antitumor activity were examined. The functional integrity of blood monocytes was determined by their capacity to respond in vitro to a variety of activating agents and become tumoricidal, as assessed by a radioactive release assay and ability to produce interleukin-1 in vitro. The results show that the presence of lung cancer significantly increased the number of harvested blood monocytes and that the spontaneous tumoricidal activity of these monocytes was slightly high as compared to monocytes obtained from healthy donors. The production of interleukin-1 by monocytes of healthy donors and lung cancer patients was similar. Blood monocytes obtained from lung cancer patients were less cytotoxic against allogeneic A375 melanoma cells as compared with those of healthy donors subsequent to incubation with a soluble muramyl dipeptide analog or lipopolysaccharide, but were as tumoricidal as those from healthy donors when activated with lipophilic muramyl tripeptide (MTP-PE) entrapped in multilamellar liposomes. The finding that monocytes of patients with lung cancer can respond to MTP-PE encapsulated in liposomes, recommends the use of these liposomes in therapy of human lung cancer.

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Authors and Affiliations

  1. 3rd Department of Internal Medicine, The University of Tokushima School of Medicine, Kuramoto-cho, 770, Tokushima, Japan

    Saburo Sone, Teruhiro Utsugi, Priti Tandon, Hiroaki Yanagawa, Akio Okubo & Takeshi Ogura

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  1. Saburo Sone
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  2. Teruhiro Utsugi
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  3. Priti Tandon
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  4. Hiroaki Yanagawa
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  5. Akio Okubo
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  6. Takeshi Ogura
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Sone, S., Utsugi, T., Tandon, P. et al. Tumor cytotoxicity and interleukin 1 production of blood monocytes of lung cancer patients. Cancer Immunol Immunother 30, 357–362 (1990). https://doi.org/10.1007/BF01786885

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  • DOI: https://doi.org/10.1007/BF01786885

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