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Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan

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Abstract

Repeated administration of the hepatic lectin blocking agents D-galactose or arabinogalactan completely prevented the settling of metastatic cells of sarcoma L-1 tumor in the liver of Balb/c mice and greatly reduced the colonization process of highly metastatic ESb lymphoma cells of the liver of DBA/2 mice. Therefore, when hepatic lectins were blocked with competitive glycoconjugates, tumor cell colonization of the liver could be prevented in two different model systems.

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Authors and Affiliations

  1. Institute of Hygiene, University of Cologne, D-5000, Cologne 41, F.R. Germany

    J. Beuth, H. L. Ko & G. Pulverer

  2. Deutsches Krebsforschungszentrum, D-6900, Heidelberg, F.R. Germany

    V. Schirrmacher

  3. Department of Immunobiology, Medical University Clinic I, D-5000, Cologne 41, F.R. Germany

    G. Uhlenbruck

Authors
  1. J. Beuth
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  2. H. L. Ko
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  3. V. Schirrmacher
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  4. G. Uhlenbruck
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  5. G. Pulverer
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Beuth, J., Ko, H.L., Schirrmacher, V. et al. Inhibition of liver tumor cell colonization in two animal tumor models by lectin blocking with D-galactose or arabinogalactan. Clin Exp Metast 6, 115–120 (1988). https://doi.org/10.1007/BF01784842

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  • DOI: https://doi.org/10.1007/BF01784842

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