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Oncogene expression in related cancer lines differing in metastatic capacity

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Abstract

Various murine tumor cell lines with different metastatic capacities were testedin vitro for oncogene expression, especially of the p21-Ha-ras protein. Small differences were seen in the expression of several distinct oncogenes in the case of a high metastatic lymphoma variant (ESb) and its low metastatic parental line (Eb). In one instance we observed a 30-fold Ha-ras gene amplification in a metastasis-derived cell line from a spontaneous mouse mammary carcinoma. In spite of this amplification we did not find an increased p21 expression in these cells.

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  1. Rüdiger Heicappell

    Present address: Chirurgische Universitätsklinik, Moorenstrasse 5, 4000, Düsseldorf, F.R. Germany

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  1. Institute for Immunology and Genetics, German Cancer Research Center, Im Neuenheimerfeld 280, 6900, Heidelberg, F.R. Germany

    Jens Pohl, Adriana Radler-Pohl, Rüdiger Heicappell & Volker Schirrmacher

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Pohl, J., Radler-Pohl, A., Heicappell, R. et al. Oncogene expression in related cancer lines differing in metastatic capacity. Clin Exp Metast 6, 201–211 (1988). https://doi.org/10.1007/BF01782480

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