Abstract
During an inflammation neutrophils are stimulated to produce reactive oxygen species (ROS). These ROS induce the release of histamine from mast cells, which are also present at the inflammation site. In this study dibutyryl cAMP differentiated HL60 cells are used as a model for human neutrophils. The effect of histamine on formyl-methionyl-leucyl-phenylalanine (fmlp) stimulated cells is examined. Except for histamine also an accumulation of ROS takes place at the inflammation site and we investigated if ROS can influence the response of the stimulated HL60 cells. It is found that 10−3 M histamine can inhibit the fmlp induced superoxide anion radical production. This occurs partly via an H2 receptor because H2 antagonists like famotidine, mifentidine and ranitidine could partially antagonize this effect of histamine. When HL60 cells are exposed to hydrogen peroxide or hypochlorous acid (20 min), an increased fmlp response is found while the inhibiting effect of histamine remains unchanged.
Similar content being viewed by others
References
Clark RA. The human neutrophil respiratory burst oxidase. J Infect Dis 1990;317:1140–7.
Morel F, Doussiere J, Vignais PV. The superoxide-generating oxidase of phagocytic cells. Eur J Biochem 1991;210:523–46.
Thelen M, Dewald B, Baggiolini M. Neutrophil signal transduction and activation of the respiratory burst. Physiol Rev 1993;73:797–821.
Chaplinski TJ, Niedel JE. Cyclic nucleotide-induced maturation of human promyelocytic leukemia cells. J Clin Invest 1982;70:953–64.
Wieland T, Gierschik P, Jakobs KH. G-protein-mediated receptor-receptor interaction: studies with chemotactic receptors in membranes of human leukemia (HL60) cells. Naunyn-Schmiedeberg's Arch Pharmacol 1992;346:475–81.
Gespach C, Saal F, Cost H, Abita JP. Identification and characterization of surface receptors of histamine in the human promyelocytic leukemia cell line HL-60. Mol Pharmacol 1982;22:547–53.
Seifert R, Hoer A, Offermanns S, Buschauer A, Schunank W. Histamine increases cytosolic Ca2+ in dibutyryl-cAMP-differentiated HL-60 cells via H1 receptors and is an incomplete secretagogue. Mol Pharmacol 1992;42:227–34.
Seifert R, Hoer A, Schwaner I, Buschauer A. Histamine increases cytosolic Ca2+ in HL-60 promyelocytes predominantly via H2 receptors with an unique agonist/antagonist profile and induces functional differentiation. Mol Pharmacol 1992;42:235–41.
Mitsuhashi M, Mitsuhashi T, Payan DG. Multiple signalling pathways of histamine H2 receptors. J Biol Chem 1989;264:18356–62.
Mitsuhashi M, Mitsuhashi T, Dazin PF, Payan DG. Agonistic activities of histamine-albumin conjugates at histamine H2 receptors on human HL-60 promyelocytic leukemia cells. Mol Pharmacol 1991;40:271–75.
Burde R, Seifert R, Buschauer A, Schultz G. Histamine inhibits activation of human neutrophils and HL-60 leukemic cells via H2-receptors. Naunyn-Schmiedelberg's Arch Pharmacol 1989;340:671–78.
Burde R, Buschauer A, Seifert R. Characterization of histamine H2-receptors in human neutrophils with a series of guanidine analogues of impromidine. Naunyn-Schmiedelberg's Arch Pharmacol 1990;341:455–61.
Cochrane CG. Cellular injury by oxidants. Am J Med 1991;91(3C):23S–30S.
Bast A, Haenen GRMM, Doelman CJA. Oxidants and antioxidants: State of the art. Am J Med 1991;91(3C):2S–13S.
Haenen GRMM, Veerman M, Bast A. Reduction ofβ-adrenoceptor function by oxidative stress in the heart. Free Rad Biol Med 1990;9:279–88.
Doelman CJA, Bast A. Oxygen radicals in lung pathology. Free Rad Biol Med 1990;9:381–400.
Fantozzi R, Brunelleschi S, Giuliattini L, Blandina P, Masini E, Gavallo G, Mannaioni PF. Mast cell and neutrophil interactions: a role for superoxide anion and histamine. Agents Actions 1985;16:260–64.
Mannaioni PF, Masini E. The release of histamine by free radicals. Free Rad Biol Med 1988;5:177–97.
Sirak AA, Laskin JD, Robertson FM, Laskin DL. Failure of f-met-leu-phe to induce chemotaxis in differentiated promyelocytic (HL-60) leukemia cells. J Leuk Biol 1990;48:333–42.
Taniguchi K, Takanaka K. Inhibitory effects of various drugs on phorbol myristate acetate and n-formyl methionyl leucyl phenylalanine induced O -2 production in polymorphonuclear leukocytes. Biochem Pharmacol 1984;33:3165–99.
Rovera G, Santoli D, Damsky C. Human promyelocytic leukemia cells in culture differentiate into macrophage-like cells when treated with a phorbol diester. Proc Natl Acad Sci USA 1979;76:2779–83.
Collins SJ, Ruscetti FW, Gallagher RE, Gallo RC. Normal functional characteristics of cultured human promyelocytic leukemia cells (HL-60) after induction of differentiation by dimethylsulfoxide. J Exp Med 1979;149:969–74.
Lord JM, Bunce CM, French PJ, Jones NA, Baxter MA, Grafton G, et al. Protein phosphorylation events and changes in inositol metabolism during HL60 cell differentiation. Biochem Soc Transactions 1991;19:315–20.
Perez HD, Kelly E, Holmes R. Regulation of formyl peptide receptor expression and its mRNA levels during differentiation of HL-60 cells. J Biol Chem 1992;267:358–63.
Tanaka Y, Yoshihara K, Tsuyuki M, Itaya-Hironaka A, Inada Y, Kamiya T. Retinoic acid-specific induction of a protein kinase C isoform during differentiation of HL-60 cells. J Biochem 1992;111:265–71.
Sadler KL, Badwey JA. Second messengers involved in superoxide production by neutrophils. Hematology 1988;2:185–200.
Johnson CL, Sawutz DG. Desensitization of histamine H2 receptor in human leukemia cells. In: Ganellin CR, Schwartz JC, eds. Frontiers in histamine research. Oxford: Pergamon Press, 1984:79–88.
Sheerin HE, Snyder LM, Fairbanks G. Cation transport in oxidant-stressed human erythrocytes: heightened N-ethylmaleimide activation of passive K+ influx after mild peroxidation. Biochim Biophys Acta 1989;983:65–76.
Barchowsky A, Kent RS, Whorton AR. Recovery of porcine aortic endothelial cell prostaglandin synthesis following inhibition by sublethal concentrations of hydrogen peroxide. Biochim Biophys Acta 1987;927:372–81.
van der Vliet A, Bast A. Effect of oxidative stress on receptors and signal transmission. Chem Biol Interact 1992;85:95–116.
Kramer K, Doelman CJA, Timmerman H, Bast A. A disbalance betweenβ-adrenergic and muscarinic responses caused by hydrogen peroxide in rat airways in vitro. Biochem Biophys Res Comm 1987;145:357–62.
Winn JS, Guille J, Gebicki JM, Day RO. Hydrogen peroxide modulation of the respiratory burst of human neutrophils. Biochem Pharmacol 1991;41:31–6.
Hyslop PA, Hinshaw DB, Schraufstatter IU, Sklar LA, Spragg RG, Cochrane CG. Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D1 cells. J Cell Physiol 1986;129:356–66.
Oosting RS, van Bree L, van Iwaarden JF, van Golde LMG, Verhoef J. Impairment of phagocytic functions of alveolar macrophages by hydrogen peroxide. Am J Physiol 1990;259:L87-L94.
Beer DJ, Matloff SM, Rocklin RE. The influence of histamine on immune and inflammatory responses. Adv Immunol 1984;35:209–68.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Ching, T.L., Koelemij, J.G. & Bast, A. The effect of histamine on the oxidative burst of HL60 cells before and after exposure to reactive oxygen species. Inflamm Res 44, 99–104 (1995). https://doi.org/10.1007/BF01782018
Received:
Revised:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01782018