Summary
The bolus injection test was used to study the intracranial volume-pressure relationships in an experimental population of normal and hydrocephalic dogs. Hydrocephalus was developed by means of an intracisternal injection of a kaolin powder solution. Hydrocephalic animals were tested a mean of 15 days after kaolin injection. The intraventricular pressure (ICPo) and amplitude of intraventricular pulse wave (AMPo) were measured at baseline steady-state. Pressure-volume index (PVI) and intracranial compliance (C) were calculated from bolus injection tests. The ICPo (p<0.01) and AMPo (p<0.001) were much higher in hydrocephalic animals and C decreased significantly (p<0.001). There were no statistical differences regarding PVI. A direct linear correlation was found between AMPo and ICPo (p<0.001) and between PVI and ICPo (p<0.05) but no correlations were found between PVI and AMPo. The regression analysis showed a non-linear correlation between C and ICPo (p<0.01) and between C and AMPo (p<0.001). The results of our experimental study suggest that: 1) pulse amplitude relates to the intracranial compliance, and 2) the intracranial compliance is a better parameter of the volume-pressure response than PVI.
Similar content being viewed by others
References
Avezaat CJJ, van Eijndhoven JHM, Wyper DJ (1979) Cerebrospinal fluid pressure and intracranial volume-pressure relationships. J Neurol Neurosurg Psychiatry 4: 687–700
Bering EA Jr (1955) Choroid plexus and arterial pulsation of cerebrospinal fluid. Arch Neurol Psychiatry 73: 165–172
Cardoso ER, Rowan JO, Galbraight S (1983) Analysis of the cerebrospinal fluid wave in intracranial pressure. J Neurosurg 59: 817–821
Foltz EL (1984) Hydrocephalus and CSF pulsatility: clinical and laboratory studies. In: Shapiro K, Marmarou A, Portnoy H (eds) Hydrocephalus. Raven Press, New York, pp 337–362
González-Darder JM, Barberá J, Cerdá-Nicolás, Segura D, Broseta J, Barcia-Salorio JL (1984) Sequental morphological and functional changes in kaolin-induced hydrocephalus. J Neurosurg 61: 918–924
Kosteljanetz M (1985) Pressure-volume conditions in patients with subarachnoid and/or intraventricular hemorrhage. J Neurosurg 63: 398–403
Kosteljanetz M (1986) CSF dynamics and pressure-volume relationships in communicating hydrocephalus. J Neurosurg 64: 45–52
Marmarou A, Shulman K, La Morguesse J (1975) Compartmental analysis of compliance and outflow resistance of the cerebrospinal fluid system. J Neurosurg 43: 523–534
Marmarou A, Shulman K, Rosende RM (1976) A non linear analysis of the cerebrospinal fluid system and intracranial pressure dynamics. J Neurosurg 48: 332–344
Matsumoto T, Nagai H, Kasuga, Kamiya K (1986) Changes in intracranial pressure (ICP) pulse wave following hydrocephalus. Acta Neurochir (Wien) 82: 50–56
Miller JD, Garibi J (1972) Intracranial volume-pressure relationships during continuous monitoring of ventricular fluid pressure. In: Brock M, Dietz H (eds) Intracranial pressure: experimental and clinical aspects. Springer, Berlin Heidelberg New York, pp 270–274
Portnoy HD, Chopp M (1981) Cerebrospinal fluid pulse form analysis during hypercapnia and hypoxia. Neurosurgery 9: 14–27
Shapiro K, Fried A, Marmarou A (1985) Biomechanical and hydrodynamic characterization of the hydrocephalic infant. J Neurosurg 63: 69–75
Shapiro K, Marmarou A (1982) Clinical applications of the pressure-volume index in treatment of pediatric head injuries. J Neurosurg 56: 819–825
Sklar FH, Linder M (1984) The role of the pressure-volume relationship of brain elasticity in the mechanics and treatment of hydrocephalus. In: Shapiro K, Marmarou A, Portnoy H (eds) Hydrocephalus. Raven Press, New York, pp 323–336
Szewczykowski J, Sliwka S, Kunicki A, Dytko P, Korsak-Sliwka J (1977) A fast method of estimating the elastance of the intracranial system. A practical application in neurosurgery. J Neurosurg 47: 19–26
Tans JTJ, Poortvliet DCJ (1983) Intracranial volume-pressure relationship in man. Part 2: Clinical significance of the pressure-volume index. J Neurosurg 59: 810–816
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Gonzĺez-Darder, J.M., Barcia-Salorio, J.L. Pulse amplitude and volume-pressure relationships in experimental hydrocephalus. Acta neurochir 97, 166–170 (1989). https://doi.org/10.1007/BF01772830
Issue Date:
DOI: https://doi.org/10.1007/BF01772830