References
Avalos BR, Gasson JC et al. (1989) Molecular characterization of the human G-CSF receptor. J Cell Biochem 13 [part C, Suppl 0]:22
Avalos BR, Gasson JC et al. (1990) Human granulocyte colony-stimulating factor: biologic activities and receptor characterization on hematopoietic cells and small cell lung cancer cell lines. Blood 75:851–857
Begley CD, Metcalf D et al. (1988) Binding characteristics and proliferative action of purified granulocyte colony-stimulating factor (G-CSF) on normal and leukemic human promyelocytes. Exp Hematol 16:71–79
Bodey GP Buckley M et al. (1966) Quantitative relationships between circulating leukocytes and infection in patients with acute leukemia. Ann Intern Med 64:328–340
Bonilla M, Gillio AP et al. (1989) Effects of recombinant human granulocyte colony-stimulating factor on neutropenia of patients with congenital agranulocytosis. N Engl J Med 320:1574–1580
Bosly A, Coiffier B et al. (1992) Bone marrow transplantation prolongs survival after relapse in aggressive lymphoma patients treated with the LNH-84 regimen. J Clin Oncol 10:1615–1623
Bronchud M (1993) Can hematopoietic growth factors be used to improve the success of cytotoxic chemotherapy? Anticancer Drugs 4:127–139
Bronchud MH, Potter MR et al. (1988) In vitro and in vivo analysis of the effects of recombinant human granulocyte colony-stimulating factor in patients. Br J Cancer 58:64–69
Bronchud MH, Scarffe JH et al. (1987) Phase-I/II study of recombinant human granulocyte colony-stimulating factor in patients receiving intensive chemotherapy for small cell lung cancer. Br J Cancer 56:809–813
Brugger W, Birken R et al. (1993) Peripheral blood progenitor cells mobilized by chemotherapy plus granulocyte colony-stimulating factor accelerate both neutrophil and platelet recovery after high-dose VP16, ifosfamide and cisplatin. Br J Haematol 84:402–407
Brugger W, Möcklin W et al. (1993) Ex vivo expansion of enriched peripheral blood CD34 + progenitor cells by stem cell factor, interleukin 1b (IL-1Β), IL-6, IL-3, interferon-γ, and erythropoietin. Blood 81:2579–2584
Budman DR, Wood W et al. (1992) Initial findings of CALGB 8541: a dose and dose-intensity trial of cyclophosphamide (c), doxorubicin (a), and 5-fluorouracil (f) as adjuvant treatment of stage II, node+, female breast cancer. Proc Am Soc Clin Oncol 11:51
Cairo MS Mauss D et al. (1990) Prophylactic or simultaneous use of recombinant human granulocyte colony-stimulating factor in the treatment of group B streptococcal sepsis in neonatal rats. Pediatr Res 27:612–616
Cohen AM, Hines DK et al. (1988) In vivo activation of neutrophil function in hamsters by recombinant human granulocyte colony-stimulating factor. Infect Immun 56:2861–2865
Crawford J, Kreisman H et al. (1992) A pharmacodynamic investigation of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) schedule variation in patients with small cell lung cancer (SCLC) given CAE chemotherapy. Proc Am Soc Oncol 11:298
Crawford J, Ozer H et al. (1991) Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer. N Engl J Med 325:164–170
Dale DC, Bonifia MA et al. (1993) A randomized controlled phase-III trial of recombinant human granulocyte colony-stimulating factor (filgrastim) for treatment of severe chronic neutropenia. Blood 81:2496–2502
Decoster G (1990) Tolerability profile of recombinant metHUG-CSF (Amgen). Ann Oncol 1:80
Delwel R, Salem M et al. (1988) Growth regulation of human acute myeloid leukemia: effects of five recombinant hematopoietic factors in a serum-free culture system. Blood 72:1944–1949
DeVita VTJ, Jaffe ES et al. (1989) Lymphocytic lymphomas. In: DeVita VTJ, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology. Lippincott, Philadelphia, pp 1741–1798
Dexter TM, Heyworth CM et al. (1990) The role of growth factors in self-renewal and differentiation of haemopoietic stem cells. Philos Trans R Soc Lond 327:85–98
Duhrsen U, Villeval JL et al. (1988) Effects of recombinant human granulocyte colony-stimulating factor on hematopoietic progenitor cells in cancer patients. Blood 72:2074–2081
Fukuda M, Kojima S et al. (1992) Autotransplantation of peripheral blood stem cells mobilized by chemotherapy and recombinant human granulocyte colony-stimulating factor in childhood neuroblastoma and non-Hodgkin's lymphoma. Br J Hematol 80:327–331
Fukunaga R, Ishizaka-Ikeda E et al. (1991) Functional domains of the granulocyte colony-stimulating factor receptor. EMBO J 10:2855–2865
Gabrilove JL, Jakubowski A et al. (1988) Phase-I study of granulocyte colony-stimulating factor in patients with transitional cell carcinoma of the urothelium. J Clin Invest 82:1454–1461
Gabrilove JL, Jakubowski A et al. (1988) Effect of granulocyte colony-stimulating factor on neutropenia and associated morbidity due to chemotherapy for transitional-cell carcinoma of the urothelium. N Engl J Med 318:1414–1422
Gianni AM, Siena S et al. (1989) Granulocyte-macrophage colony-stimulating factor to harvest circulating haematopoietic stem cells for autotransplantation. Lancet 2:580–585
Gisselbrecht C, Prentice HG et al. (1994) Placebo-controlled phase-III trial of lenograstim in bone-marrow transplantation. Lancet 343:696–700
Greenberg P, Taylor K et al. (1993) Phase-III randomised multicenter trial of G-CSF vs. Observation for myelodysplastic syndrome (MDS). Blood 82 [Suppl]:196a
Griffin JD, Young D et al, (1986) Effects of recombinant human GM-CSF on proliferation of clonogenic cells in acute myeloblastic leukemia. Blood 67:1448–1453
Groopman JE, Molina J-M et al. (1989) Hematopoietic growth factors: biology and clinical applications. N Engl J Med 321:1449–1459
Haas R, Hohaus H et al. (1992) Autologous blood stem cell transplantation in Hodgkin's disease the impact of rhG-CSF on blood stem cell collection. Bone Marrow Transplant 10:5
Hebert JC, O'Reilly M et al. (1990) Protective effect of recombinant human granulocyte colony-stimulating factor against pneumococcal infection in splenectomized mice. Arch Surg 125:1075–1078
Hellman S, Jaffe ES et al. (1989) Hodgkin's disease. In: DeVita VT, Hellman S, Rosenberg S (eds) Cancer principles and practice of oncology. Lippincott, Philadelphia, pp 1696–1740
Henderson IC, Hayes DF et al. (1988) Dose-response in the treatment of breast cancer: a critical review. J Clin Oncol 6:1501–1515
Hohaus S, Goldschmidt H et al. (1993) Successful autografting following myeloablative conditioning therapy with blood stem cells mobilized by chemotherapy plus rhG-CSF. Exp Hematol 21:508–514
Hryniuk W, Levine MN (1986) Analysis of dose intensity for adjuvant chemotherapy trials in ovarian cancer. J Clin Oncol 4:1162
Iki S, Yoshinaga K et al. (1993) Cytotoxic drug-induced pneumonia and possible augmentation by G-CSF — clinical attention. Ann Hematol 66:217–218
Inoue C, Murate T et al. (1990) Response of leukemic cells to the sequential combination of GM-CSF and G-CSF. International J Cell Cloning 8:54–62
Kanazawa M, Ishizaka A et al. (1992) Granulocyte colony-stimulating factor does not enhance endotoxin-induced acute lung injury in guinea pigs. Am Rev Resp Dis 145:1030–1035
Katoh M, Shikoshi K et al. (1993) Development of interstitial pneumonitis during treatment with granulocyte colony-stimulating factor. Ann Hematol 67:201–202
Kawakami M, Tsutsumi H et al. (1990) Levels of serum granulocyte colony-stimulating factor in patients with infections. Blood 76:1962–1964
Kawano Y, Takaue Y et al. (1993) Effects of progenitor cell dose and preleukapheresis use of human recombinant granulocyte colony-stimulating factor on the recovery of hematopoiesis after blood stem cell autografting in children. Exp Hematol 21:103–108
Kaye SB, Lewis CR et al. (1992) Randomized study of two doses of cisplatin with cyclophosphamide in epithelial ovarian cancer. Lancet 340:329–333
Koizumi T, Kubo K et al. (1993) Granulocyte colony-stimulating factor does not exacerbate endotoxin-induced lung injury in sheep. Am Rev Resp Dis 148:132–137
Laver J, Moore MAS (1989) Clinical use of recombinant human haematopoietic growth factors. Natl Cancer Inst 81:1370–1382
Lindemann A, Herrmann F et al. (1989) Hematologic effects of recombinant human granulocyte colony-stimulating factor in patients with malignancy. Blood 74:2644–2651
Lord BI, Bronchud MH et al. (1989) The kinetics of human granulopoiesis following treatment with granulocyte colony-stimulating factor in vivo. Proc Natl Acad Sci USA 86:9499–9503
Maher M, Green J et al. (1993) Randomized, placebo-controlled trial of filgrastim (r-metHuG-CSF) in patients with febrile neutropenia (FN) following chemotherapy (CT). Proc Am Soc Oncol 12:443
Maslack P, Weiss M et al. (1993) Combination of biologic agents with chemotherapy limits toxicity in the treatment of elderly patients with AML. Blood 82S:130a
Matthews JH (1993) Pulmonary toxicity of ABVD chemotherapy and G-CSF in Hodgkin's disease: possible synergy. Lancet 342:988
McGuire WP, Hoskins WJ et al. (1992) A phase-III trial of dose-intense (DI) versus standard-dose (DS) cisplatin (CDDP) and cytoxan (CTX) in advanced ovarian cancer (AOC). Proc Am Soc Clin Oncol 11:226
Mempel K, Pietsch T et al. (1991) Increased serum levels of granulocyte colony-stimulating factor (G-CSF) in patients with severe congenital neutropenia. Blood 77:1919–1922
Meropol NJ, Miller LL et al. (1992) Severe myelosuppression resulting from concurrent administration of granulocyte colony-stimulating factor and cytotoxic chemotherapy. J Nat Cancer Inst 84:1201–1203
Michon J, Hartmann O et al. (1992) Preliminary analysis of the first open-label randomized phase-III study of recombinant granulocyte colony-stimulating factor as an adjunct to combination induction chemotherapy in pediatric patients with metastatic neuroblastoma. Blood 80 [Supp] 1:248a
Minna JD, Pass H et al. (1989) Cancer of the lung. In: DeVita VT, Hellman S, Rosenberg SA (eds) Cancer principles and practice of oncology. Lippincott, Philadelphia, pp 591–705
Morstyn G, Campbell L et al. (1988) Clinical studies with granulocyte colony-stimulating factor (G-CSF) in patients receiving cytotoxic chemotherapy. Behring Inst Mitt 83:234–239
Morstyn G, Campbell L et al. (1988) Effect of granulocyte colony-stimulating factor on neutropenia induced by cytotoxic chemotherapy. Lancet 1:667–672
Nagata S, Tsuchiga M et al. (1986) Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor. Nature 319:415–418
Negrin RS, Haeuber DH et al. (1989) Treatment of myelodysplastic syndromes with recombinant human granulocyte colony-stimulating factor. A phase I–II trial. Ann Intern Med 110:976–984
Negrin RS, Haeuber DH et al. (1990) Maintenance treatment of patients with myelodysplastic syndromes using recombinant human granulocyte colony-stimulating factor. Blood 76:36–43
Nicola NA (1987) Why do hemopoietic growth factor receptors interact with each other. Immunol Today 8:134–140
Nicola NA (1989) Hemopoietic cell growth factors and their receptors. Annu Rev Biochem 58:45–77
Ohno R, Hiraoka A et al. (1993) No increase of leukemia relapse in newly diagnosed patients with acute myeloid leukemia who received granulocyte colony-stimulating factor for life-threatening infection during remission induction and consolidation therapy. Blood 81:561–562
Ohno R, Tomonaga M et al. (1990) Effect of granulocyte colony-stimulating factor after intensive induction therapy in relapsed or refractory acute leukemia. N Engl J Med 323:871–877
Ottmann OG, Ganser A et al. (1993) Simultaneous administration of granulocyte colony-stimulating factor (filgrastim) and induction chemotherapy in acute lymphoblastic leukemia (ALL). Ann Hematol 67:161–167
Ottmann OG, Hoelzer D et al. (1993) Concomitant R-metHuG-CSF (filgrastim) and intensive chemoradiotherapy as induction treatment in adult ALL: a randomised multicenter phase-III trial. Blood 82S:193a
Peters WP, Kurtzberg J et al. (1989) Comparative effects of rHuG-CSF and rHuGM-CSF on hematopoietic reconstitution and granulocyte function following high-dose chemotherapy and autologous bone marrow transplantation (ABMT). Proc Am Soc Clin Oncol 8:181
Petros WP, Peters WP (1993) Hematopoietic colony-stimulating factors and dose intensity. Semin Oncol 20:94–99
Pettengell R, Gurney H et al. (1992) Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: a randomized controlled trial. Blood 80:1430–1436
Pettengell R, Morgenstern GR et al. (1993) Peripheral blood progenitor cell transplantation in lymphoma and leukemia using a single apheresis. Blood 82:3770–3777
Philip T, Armitage JO et al. (1987) High-dose therapy and autologous bone marrow transplantation after failure of conventional chemotherapy in adults with intermediate-grade or high-grade non-Hodgkin's lymphoma. N Engl J Med 316:1493–1498
Platzer E, Welte K et al. (1985) Biological activities of a human pluripotent hematopoietic colony-stimulating factor on normal and leukemic cells. J Exp Med 162:1788–1801
Roilides E, Walsh TJ et al. (1991) Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils. J Infect Dis 163:579–583
Samson MK, Rivkin SE et al. (1984) Dose-response and dose-survival advantage for high- versus low-dose cisplatin combined with vinblastine and bleomycin in disseminated testicular cancer. Cancer 53:1029–1035
Sartorelli KH, Silver GM et al. (1991) The effect of granulocyte colony-stimulating factor (G-CSF) upon burn-induced defective neutrophil chemotaxis. J Trauma 31:523–529
Sato N, Shimizu H (1993) Granulocyte-colony stimulating factor improves an impaired bactericidal function in neutrophils from STZ-induced diabetic rats. Diabetes 42:470–473
Scherrer R, Geissler K et al. (1993) Granulocyte colony-stimulating factor (G-CSF) as an adjunct to induction chemotherapy of adult acute lymphoblastic leukemia (ALL). Ann Hematol 66:283–289
Schmitz N, Dreger P et al. (1993) A randomized, controlled, multicentre study of granulocyte colony-stimulating factor (filgrastim) in patients with Hodgkin's disease and non-Hodgkin's lymphoma undergoing autologous bone marrow transplantation. Blood 82.S:146a
Sheridan WP, Begley CG et al. (1992) Effect of peripheral-blood progenitor cells mobilised by filgrastim (G-CSF) on platelet recovery after high-dose chemotherapy. Lancet 339:640–644
Sheridan WP, Morstyn G et al. (1989) Granulocyte colony-stimulating factor and neutrophil recovery after high-dose chemotherapy and autologous bone marrow transplantation. Lancet 2:891–895
Shishido K, Nukura K et al. (1991) The effects and pharma-cokinetics of rhG-CSF on the treatment of neutropenia in patients with renal failure. Nippon Jinzo Gakkai Shi 33:973–981
Shpall EJ, Jones RB et al. (1993) Transplantation of enriched autologous CD34+ hematopoietic progenitor cells into breast cancer patients following high-dose chemotherapy. Am Soc Clin Oncol 12:105
Skipper HE (1967) Criteria associated with destruction of leukemia and solid tumor cells in animals. Cancer Res 27:2636–2645
Souza LM, Boone TC et al. (1986) Recombinant human granulocyte colony-stimulating factor: effects on normal and leukemic myeloid cells. Science 232:61–65
Stahel RA, Lorenz MJ et al. (1994) A randomized study of recombinant human granulocyte colony-stimulating factor (filgrastim) after high-dose chemotherapy and autologous bone marrow transplantation for high-risk lymphoid malignancies. J Clin Oncol, in press
Stute N, Santana VM et al. (1992) Pharmacokinetics of subcutaneous recombinant human granulocyte colony-stimulating factor in children. Blood 79:2849–2854
Tanaka H, Tokiwa T (1990) Influence of renal and hepatic failure on the pharmacokinetics of recombinant human granulocyte colony-stimulating factor (KRN8601) in the rat. Cancer Res 50:6615–6619
Taylor KM, Jagannath S et al. (1989) Recombinant human granulocyte colony-stimulating factor hastens granulocyte recovery after high-dose chemotherapy and autologous bone marrow transplantation. J Clin Oncol 7:1791–1799
Teshima H, Ishikawa J et al. (1989) Clinical effects of recombinant human granulocyte colony-stimulating factor in leukemia patients: a phase-I/II study. Exp Hematol 17:853–858
Trillet-Lenoir V, Green J et al. (1993) Recombinant granulocyte colony-stimulating factor reduces the infectious complications of cytotoxic chemotherapy. Eur J Cancer 29A:319–324
Vadhan-Raj S, Keating M et al. (1987) Effects of recombinant human granulocyte-macrophage colony-stimulating factor in patients with myelodysplastic syndromes. N Engl J Med 317:1545–1549
Valerius T, Repp R et al. (1993) Involvement of the high-affinity receptor for IgG (FcγRI; CD64) in enhanced tumor cell cytotoxicity of neutrophils during granulocyte colony-stimulating factor therapy. Blood 82:931–939
van Rijswijk R, Haanen C et al. (1989) Dose intensity of MOPP chemotherapy and survival in Hodgkin's disease. J Clin Oncol 7:1776–1782
Vellenga E, Ostapovicz D et al. (1987) Effects of recombinant IL-3, GM-CSF and G-CSF on proliferation of leukemic clonogenic cells in short-term and long-term cultures. Leukemia 1:584–589
Watari K, Asano S et al. (1989) Serum granulocyte colony-stimulating factor levels in healthy volunteers and patients with various disorders as estimated by enzyme immunoassay. Blood 73:117–122
Welte K, Mempel K et al. (1993) A randomised phase-III study of recombinant human granulocyte colony-stimulating factor (r-metHuG-CSF) in childhood high-risk acute lymphoblastic leukemia. Blood 82S:194a
Welte K, Platzer E et al. (1985) Purification and biochemical characterization of human pluripotent hematopoietic colony-stimulating factor. Proc Natl Acad Sci USA 82:1526–1530
Welte K, Zeidler C et al. (1990) Differential effects of granulocyte-macrophage colony-stimulating factor and granulocyte colony-stimulating factor in children with severe congenital neutropenia. Blood 75:1056–1063
Yasuda H, Ajiki Y et al. (1990) Therapeutic efficacy of granulocyte colony-stimulating factor alone or in combination with antibiotics againsPseudomonas aeruginosa infections in mice. Infect Immun 58:2502–2509
Yoshida Y, Hirashima K et al. (1991) A phase-II trial of recombinant human granulocyte colony-stimulating factor in the myelodysplastic syndromes. Br J Hematol 78:378–384
Zeidler C, Reiter A et al. (1993) Langzeitbehandlung mit rekombinanten humanen Granulozyten-Kolonien stimulierendem Faktor bei Patienten mit schwerer kongenitaler Neutropenie. Klin Padiatr 205:264–271
Zeidler C, Reiter A et al. (1994) Long-term effects of r-metHuG-CSF treatment in patients with severe congenital neutropenia. Rev Invest Clin [Suppl]:251
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Schwab, G., Hecht, T. Recombinant methionyl granulocyte colony-stimulating factor (filgrastim): A new dimension in immunotherapy. Ann Hematol 69, 1–9 (1994). https://doi.org/10.1007/BF01757341
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DOI: https://doi.org/10.1007/BF01757341