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Progressive multifocal leukoencephalopathy: Neurological findings and evaluation of magnetic resonance imaging and computed tomography

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Abstract

On the basis of two of our cases we report here on the clinical symptoms and neuroradiological findings in patients with progressive multifocal leukoencephalopathy. Emphasis is put on the value of MRI in early stages of this disease, especially, and on the increased information provided by this method as compared to CT-scanning.

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References

  1. Aksamit AJ, P Mourrain, JL Sever, EO Major: Progressive multifocal leukoencephalopathy: investigation of three cases using in situ hybridization with JC virus biotinylated DNA probe. Ann Neurol 18 (1985) 490–496

    Google Scholar 

  2. Åström KE, EL Mancall, EP Richardson, Jr.: Progressive multifocal leukoencephalopathy: Hitherto unrecognized complication of chronic lymphatic leukemia and Hodgkin's disease. Brain 81 (1958) 93–110

    Google Scholar 

  3. Bolton CF, B Rozdilsky: Primary progressive multifocal leukoencephalopathy. A case report. Neurology 21 (1971) 72–77

    Google Scholar 

  4. Carroll BA, B Lane, D Norman, D Enzmann: Diagnosis of progressive multifocal leukoencephalopathy by computed tomography. Radiology 122 (1977) 137–141

    Google Scholar 

  5. Cavanagh JB, D Greenbaum, AHE Marshall, LJ Rubinstein: Cerebral demyelination associated with disorders of the reticuloendothelial system. Lancet II (1959) 524–529

    Google Scholar 

  6. Conomy JP, MA Weinstein, D Agamanolis, WS Holt: Computed tomography in progressive multifocal leukoencephalopathy. Am J Roentgenol 127 (1976) 663–665

    Google Scholar 

  7. Faris AA, AJ Martinez: Primary progressive multifocal leukoencephalopathy. A central nervous system disease caused by a slow virus. Arch Neurol 27 (1972) 357–360

    Google Scholar 

  8. Gagne F, J-P Bouchard, J-P Bernier: Leucoéncephalopathie multifocale progressive. Acta Neuropathol (Berl) 38 (1977) 167–169

    Google Scholar 

  9. Hedley-Whyte ET, BP Smith, HR Tyler, WP Peterson: Multifocal leukoencephalopathy with remission and five year survival. J Neuropathol Exp Neurol 25 (1966) 107–116

    Google Scholar 

  10. Johnson RT: Viral Infections of the Nervous System. Raven Press, New York 1984

    Google Scholar 

  11. Krupp LB, RB Lipton, NE Leeds, J Llena, CR Smith, MS Swerdlow: A recent cluster of progressive multifocal leukoencephalopathy: Clinical, radioraphic, and epidemiological features. Ann Neurol 16 (1984) 152

    Google Scholar 

  12. Krupp LB, RB Lipton, ML Swerdlow, NE Leeds, J Llena: Progressive multifocal leukoencephalopathy: Clinical and radiographic features. Ann Neurol 17 (1985) 344–349

    Google Scholar 

  13. McCormick WF, SS Schochet Jr, HE Sarles, JR Calverley: Progressive multifocal leukoencephalopathy in renal transplant recipients. Arch Intern Med 136 (1976) 829–834

    Google Scholar 

  14. Miller JR, RE Barrett, CB Britton, ML Tapper, GS Bahr, PJ Bruno, MD Marquardt, AP Hays, JG McMurtry, JB Weissman, MS Bruno: Progressive multifocal leukoencephalopathy in a male homosexual with T-cell immune deficiency. N Engl J Med 307 (1982) 1436–1437

    Google Scholar 

  15. Narayan O, JB Penney, RT Johnson, RM Herndon, LP Weiner: Etiology of progressive multifocal leukoencephalopathy. Identification of Papovavirus. New Engl J Med 13 (1973) 1278–1282

    Google Scholar 

  16. Padgett BL, DL Walker, GM Zu Rhein: Cultivation of Papova-like virus from human brain with progressive multifocal leukoencephalopathy. Lancet 1 (1971) 1257–1260

    Google Scholar 

  17. Price RW, S Nielsen, B Horten, M Rubino, B Padgett, D Walker: Progressive multifocal leukoencephalopathy: A burnt-out case. Ann Neurol 13 (1983) 485–490

    Google Scholar 

  18. Zu Rhein GM, SM Chou: Particles resembling papovaviruses in human cerebral demyelinating disease. Science 148 (1965) 1477

    Google Scholar 

  19. Ries F: Progressive multifokale Leukoenzephalopathie bei Hämophilie A: Besteht ein Zusammenhang mit AIDS? Nervenarzt 56 (1985) 442–448

    Google Scholar 

  20. Schröder R, W Schorre, HE Schaefer: Die progressive multifokale Leukoenzephalopathie. Med Welt 34 (1983) 900–905

    Google Scholar 

  21. Silverman L, LJ Rubinstein: Electron microscopic observations on a case of progressive multifocal leukoencephalopathy. Acta Neuropathol (Berlin) 5 (1965) 215

    Google Scholar 

  22. Sponzilli EE, JK Smith, N Malamud, J McCulloch: Progressive multifocal leukoencephalopathy: A complication of immunosuppressive treatment. Neurology 25 (1975) 664–668

    Google Scholar 

  23. Walker DL, BL Padgett, GM Zu Rhein, AE Albert, RF Marsh: Current Study of an Opportunistic Papovavirus. In:Zeman W, EW Lennette, JG Brunson (eds): Slow Virus Diseases. The Williams & Wilkins Company, Baltimore 1974

    Google Scholar 

  24. Weiner LP, RM Herndon, O Narayan, RI Johnson, K Shah, LJ Rubinstein, TJ Preziosi, FK Conley: Isolation of virus related to SV 40 from patients with progressive multifocal leukoencephalopathy. N Engl J Med 8 (1972) 385–389

    Google Scholar 

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Authors and Affiliations

  1. Department of Neurology, University of Essen, West Germany

    Susanne Koeppen & Hans-Joachim Lehmann

  2. Neurologische Universitätsklinik der Gesamthochschule Essen, Hufelandstraße 55, D-4300, Essen 1, West Germany

    Susanne Koeppen & Hans-Joachim Lehmann

Authors
  1. Susanne Koeppen
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  2. Hans-Joachim Lehmann
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Koeppen, S., Lehmann, HJ. Progressive multifocal leukoencephalopathy: Neurological findings and evaluation of magnetic resonance imaging and computed tomography. Neurosurg. Rev. 10, 127–132 (1987). https://doi.org/10.1007/BF01741449

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  • DOI: https://doi.org/10.1007/BF01741449

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