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Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions

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Summary

After oral administration of 5-aminosalicylic acid a substantial proportion of the acetylated form is excreted in the faeces. We have studied the role of the faecal microflora in acetylating 5-aminosalicylic acid.

In faeces incubated under both aerobic and anaerobic conditions there was acetylation of 5-aminosalicylic acid. Of the anaerobic bacteria isolated from a 108 faecal dilution 44% were able to acetylate 5-aminosalicylic acid.

We conclude that the normal faecal microflora contribute to the acetylation of 5-aminosalicylic acid.

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Authors and Affiliations

  1. Department of Medicine, Division of Gastroenterology, St. Radboud Hospital, P.O. Box 9101, 6500, Nijmegen, The Netherlands

    R. A. van Hogezand, A. van Schaik, P. A. M. van Hees & J. H. M. van Tongeren

  2. Department of Central Animal Laboratory, University of Nijmegen, P.O. Box 9101, 6500, Nijmegen, The Netherlands

    H. M. Kennis & J. P. Koopman

  3. Department of Gastroenterology and Hepatology, University Hospital, Building 1, C4-PO12 Rijnsburgerweg 10, 2333 AA, Leiden, The Netherlands

    R. A. van Hogezand

Authors
  1. R. A. van Hogezand
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  2. H. M. Kennis
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  3. A. van Schaik
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  4. J. P. Koopman
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  5. P. A. M. van Hees
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  6. J. H. M. van Tongeren
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van Hogezand, R.A., Kennis, H.M., van Schaik, A. et al. Bacterial acetylation of 5-aminosalicylic acid in faecal suspensions cultured under aerobic and anaerobic conditions. Eur J Clin Pharmacol 43, 189–192 (1992). https://doi.org/10.1007/BF01740669

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  • DOI: https://doi.org/10.1007/BF01740669

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