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Dynamin: Motor protein or regulatory GTPase

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Conclusion

Most of the genetic and cytochemical analysis of dynamin supports a role in membrane sorting, with little indication of a role for microtubules. None the less, evidence for such a role persists fromin vitro experiments. The most obvious solution to this dilemma seems to be that, despite evidence for specificity of the interaction with microtubules fromin vitro work, microtubules mimic a yet-to-be-identified cellular regulator of dynamin function. Alternatively, microtubules may participate in the early stages of endocytosis in a previously unrecognized manner, perhaps even indirectly. Resolving these issues will clearly be of paramount interest in the next phase of experimentation.

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  1. Cell Biology Group, Worcester Foundation for Experimental Biology, 01545, Shrewsbury, MA, USA

    Richard B. Vallee

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Vallee, R.B. Dynamin: Motor protein or regulatory GTPase. J Muscle Res Cell Motil 13, 493–496 (1992). https://doi.org/10.1007/BF01737991

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