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Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD)

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Abstract

Brain single-photon emission tomography (SPET) withN,N″-1,2-ethylene-diylbis-l-cysteine diethyl ester dihydrochloride (ECD) was performed on ten patients with a clinically high grade late whiplash syndrome and on 11 controls. Two independent readers blinded to the clinical diagnosis were able to separate the ten patients from normal controls. All these patients had qualitative bilateral parieto-occipital hypoperfusion. To confirm this, the perfusion rate of parieto-occipital over global (perfusion index) was calculated after drawing elliptical regions of interest in transversal-oblique slices. The perfusion indices in patients were significantly lower than in controls as tested by the Mann-WhitneyU test. This quantitative study proves our recent qualitatively analysed observation (Lancet 1995; 345: 1513–1514).

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Authors and Affiliations

  1. Institute of Nuclear Medicine, University Hospital Basel, Petersgraben 4, CH-4031, Basel, Switzerland

    Andreas Otte

  2. Rehabilitation Clinic, Rheinfelden, Switzerland

    Thierry Ettlin

  3. Neurologist, Bern, Switzerland

    Lukas Fierz

Authors
  1. Andreas Otte
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  2. Thierry Ettlin
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  3. Lukas Fierz
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  4. Jan Mueller-Brand
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Otte, A., Ettlin, T., Fierz, L. et al. Parieto-occipital hypoperfusion in late whiplash syndrome: first quantitative SPET study using technetium-99m bicisate (ECD). Eur J Nucl Med 23, 72–74 (1996). https://doi.org/10.1007/BF01736993

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  • DOI: https://doi.org/10.1007/BF01736993

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