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Human dirofilariasis with reactive arthritis — Case report and review of the literature

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Summary

A 43-year-old German man suffered from an insect bite, which was followed by a severe local inflammation and lymphadenitis. A year later, he developed dry cough, chest pain, and an oligoarthritis of the ankle and knee joints. While other causes of the symptoms could be excluded, serologic findings suggested a dirofilarial infection with reactive arthritis due to the parasite. The observation points out, that in cases of unclassifiable mono- or oligoarthritis, reactive arthritis due to parasites should be considered in the spectrum of differential diagnoses. The disease is rare at present, but its frequency might be underestimated because of the diagnostic difficulties. Dirofilarial infection should be borne in mind after a stay abroad. The present case, however, shows, that the disease also occurs in patients who had not travelled to regions of risk in recent years.

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Abbreviations

D:

Dirofilaria

Elisa:

Enzyme-linked immunosorbent assay

FAT:

Fluorescent antibody test

ICS:

Intercostal space

IGE:

Immunoglobulin E

IHA:

Indirect hemagglutination

References

  1. Adkins RB, Dao AH (1984) Pulmonary dirofilariasis: a diagnostic challenge. South Med J 77:372–374

    Google Scholar 

  2. Almond NM, Parkhouse RME (1985) Nematode antigens. Curr Top Microbiol Immunol 120:173–203

    Google Scholar 

  3. Ambroise-Thomas P (1974) Immunological diagnosis of human filariasis: present possibilities, difficulties and limitations (a review). Acta Trop (Basel) 31:108–128

    Google Scholar 

  4. Awe RJ, Mattox KL, Alvarez BA, Storck WJ, Estrada R, Greenberg SD (1975) Solitary and bilateral pulmonary nodules due toDirofilaria immitis. Am Rev Resp Dis 112:445–449

    Google Scholar 

  5. Bardach H, Heimbucher J, Raff M (1981) Subkutane Dirofilaria (Nochtiella) repens-Infektion beim Menschen — Erste Fallbeschreibung in Österreich und Übersicht der Literatur. Wiener Klin Wochenschr 93:123–127

    Google Scholar 

  6. Beaver PC, Brenes R, Ardon J (1986) Dirofilaria from the index finger of a man in Costa Rica. Am J Trop Med Hyg 35:988–990

    Google Scholar 

  7. Beskin CA, Colvin SH, Beaver PC (1966) Pulmonary dirofilariasis. JAMA 198:665–667

    Google Scholar 

  8. Brine JAS, Finlay-Jones CR, Charters AD (1971) Pulmonary dirofilariasis — a case in Western Australia. Med J Austr 2:1238–1241

    Google Scholar 

  9. Bruijning CFA (1981) Human dirofilariasis. A report of the first case of ocular dirofilariasis in the Netherlands and a review of the literature. Trop Geogr Med 33:295–305

    Google Scholar 

  10. Caravelli JF, Zaman MB, Bains MS (1981) Human pulmonary dirofilariasis mimicking metastatic disease. Clin Bull 11:88–90

    Google Scholar 

  11. Case Records of the Massachusetts General Hospital (1979) N Engl J Med 300:723–729

    Google Scholar 

  12. Chesney TM, Martinez LC, Painter MW (1983) Human pulmonary dirofilarial granuloma. Ann Thorac Surg 36:214–217

    Google Scholar 

  13. Ciferri F (1981) Human pulmonary dirofilariasis in the West. West J Med 134:158–160

    Google Scholar 

  14. Ciferri F (1982) Human pulmonary dirofilariasis in the United States: a critical review. Am J Trop Med Hyg 31(2):302–308

    Google Scholar 

  15. Ciferri F (1984) Pulmonary dirofilarial granuloma (letter). Ann Thorac Surg 38:298

    Google Scholar 

  16. Conly JM, Sekla LH, Low DE (1984) Dirofilariasis presenting as a breast lump. Can Med Assoc J 130:1575–1576

    Google Scholar 

  17. Faust EC (1957) Human infection with species of Dirofilaria. Z Tropenmed Parasitenkd 8:59–68

    Google Scholar 

  18. Feld H (1973)Dirofilaria immitis (dog heartworm) as a cause of a pulmonary lesion in man. Radiology 108:311–312

    Google Scholar 

  19. Fujita K, Tanaka H, Manabu S (1970) Cross-reaction among Filarial species in hemagglutination tests. Jpn J Exp Med 40:67–77

    Google Scholar 

  20. Gershwin LJ, Gershwin ME, Leritzman J (1974) Human pulmonary dirofilariasis. Chest 66:92–96

    Google Scholar 

  21. Glickman LT, Grieve RB, Schantz PM (1986) Serologic diagnosis of zoonotic pulmonary dirofilariasis. Am J Med 80:160–164

    Google Scholar 

  22. Goodman ML, Gore I (1964) Pulmonary infarct secondary to Dirofilaria larvae. Arch Intern Med 113:702–705

    Google Scholar 

  23. Grieve RB, Lok JB, Glichman LT (1983) Epidemiology of canine heartworm infection. Epidemiol Rev 5:220–246

    Google Scholar 

  24. Grieve RB, Knight DH (1985) Anti-Dirofilaria immitis anti-body levels before and after anthelminthic treatment of experimentally infected dogs. J Parasitol 71:56–61

    Google Scholar 

  25. Harrison EG, Thompson JH (1965) Dirofilariasis of human lung. Am J Clin Pathol 43:224–234

    Google Scholar 

  26. Hawkins AG, Hsin JG, Smith RM, Stitik FP, Siddiky MA, Edwards OE (1985) Pulmonary dirofilariasis diagnosed by fine needle aspiration biopsy. A case report. Acta Cytol 29:19–22

    Google Scholar 

  27. Hendricks GL, Barnes WT, Cerman DS (1973)Dirofilaria immitis. Ann Thorac Surg 16:526–530

    Google Scholar 

  28. Herzer P, Wilske B, Preac-Music V, Schierz G, Schattenkirchner M, Zöllner N (1986) Lyme arthritis: clinical features, serological and radiological findings of cases in Germany. Klin Wochenschr 64:206–215

    Google Scholar 

  29. Hoch WS, Wershba ME, Patchefsky AS (1974) Pulmonary dirofilariasis. J Thorac Cardiovasc Surg 67:159–163

    Google Scholar 

  30. Kahn FW, Wester SM, Agger WA (1983) Pulmonary dirofilariasis and transitional cell carcinoma. Arch Intern Med 143:1259–1260

    Google Scholar 

  31. Kiesselbach K (1967) Ein Fall von Dirofilariosis in Deutschland. Dtsch Med Wochenschr 51:2353–2356

    Google Scholar 

  32. Knobloch J, Delgado EA (1985) Immunodiagnosis of cysticercosis: standardization of Elisa and its application to field conditions. Tropenmed Parasit 36:157–159

    Google Scholar 

  33. Kochar AS (1985) Human pulmonary dirofilariasis. Report of three cases and brief review of the literature. Am J Clin Pathol 84:19–23

    Google Scholar 

  34. Leonardi HK, Lapey JD, Ellis FH (1977) Pulmonary dirofilariasis: report of a human case. Thorax 32:612–615

    Google Scholar 

  35. Levinson ED, Ziter FMH, Westcott JL (1979) Pulmonary lesions due toDirofilaria immitis (dog heartworm). Radiology 131:305–307

    Google Scholar 

  36. Lewis JF, Williams RW, Tinsley EA (1969) Pulmonary “coin” lesion due toDirofilaria immitis. Arch Surg 98:388–390

    Google Scholar 

  37. Mannweiler E, Büttner DW, Mohr W, Röllinghoff W, Mühl H, Lederer I, Dietz G (1977) Beiträge zur Immundiagnostik der Filariosen bei Tropenrückkehrern sowie europäischen und autochtonen Bewohnern von Endemiegebieten. Infection 5:219–223

    Google Scholar 

  38. Martire JR, Liberman II, Goldman SM (1975)Dirofilaria immitis (dog heartworm) as a cause of pulmonary infarction in man. Md State Med J 24:62–63

    Google Scholar 

  39. Merrill JR, Otis J, Logan WD, Davis MB (1980): The dog heartworm (Dirofilaria immitis) in man. An epidemic pending or in progress? JAMA 243:1066–1068

    Google Scholar 

  40. Moorhouse DE (1978):Dirofilaria immitis: a cause of human intra-ocular infection. Infection 6:192–193

    Google Scholar 

  41. Moorhouse DE, Abrahams EW, Stephens BJ (1971) Human pulmonary dirofilariasis in Queensland. Med J Austr 2:1230–1233

    Google Scholar 

  42. Navarette AR (1972) Pulmonary dirofilariasis. Chest 61:51–55

    Google Scholar 

  43. Navarette-Reyna A, Noon G (1968) Pulmonary dirofilariasis manifested as a coin lesion. Report of a case and review of the literature. Arch Pathol 85:266–271

    Google Scholar 

  44. Neafie RC (1976) Dirofilariasis. In: Binford CH, Connor DM (eds) Pathology of tropical and extraordinary diseases, vol 2. Armed forces Institute of Pathology, Washington, D.C., pp 391–396

    Google Scholar 

  45. Neafie RC, Piggott MAgg (1971) Human pulmonary dirofilariasis. Arch Pathol 92:342–349

    Google Scholar 

  46. Nelson RP, Thomason WB (1985) Human dirofilariasis of the bladder. J Urol 133:677–678

    Google Scholar 

  47. Neppert J (1974) Cross-reacting antigens among some Filariae and other nematodes. Tropenmed Parasit 25:454–463

    Google Scholar 

  48. Pacheo G (1966) Progressive changes in certain serological responses toDirofilaria immitis infection in the dog. J Parasit 52:311–317

    Google Scholar 

  49. Pampiglione S, Rivasi F, Trotti GC (1984) Human pulmonary dirofilariasis in Italy (letter). Lancet I:333

    Google Scholar 

  50. Prioleau WH, Parker EF, Brodham RR, Gregorie HB (1976)Dirofilaria immitis (dog heartworm) as a pulmonary lesions in humans. Ann Thorac Surg 21:382–385

    Google Scholar 

  51. Riskin MW, Toppell KL (1977) Pulmonary dirofilariasis: another coin lesion. South Med J 70:502–503

    Google Scholar 

  52. Robinson NB, Chevez CM, Conn JH (1977) Pulmonary dirofilariasis in man. A case report and review of the literature. J Thorac Cardiovasc Surg 74:403–408

    Google Scholar 

  53. Rüdt R (1986) Die reaktive Arthritis bei Parasiteninfestation. Akt Rheumatol II:19–22

    Google Scholar 

  54. Sato M, Koyama A, Iwai K, Kawabota Y, Kojima S (1985) Human pulmonary dirofilariasis with special reference to the ELISA for the diagnosis and follow-up study. Z Parasitenkd 71:361–563

    Google Scholar 

  55. Schlotthauer JC, Harrison EG, Thompson JH (1969) Dirofilariasis — an emerging zoonosis? Arch Environ Health 19:887–890

    Google Scholar 

  56. Smith HA, Jones TC (1961) Veterinary pathology. Lea and Febiger, Philadelphia, pp 516–519

    Google Scholar 

  57. Soulsby EJL (1968) Helminths. In: Arthropods and Protozoa of domesticated animals. Baikier, Tindall and Cassell, London, pp 294–298

    Google Scholar 

  58. Spear HC, Daughtry DC, Chesny JG, Gentsch TO, Larsen PB (1968) Solitary pulmonary lesion due to Dirofilaria. N Engl J Med 278:832–833

    Google Scholar 

  59. Steere AC, Malawista SE, Snydman DR, Andiman WS (1976) A cluster of arthritis in children and adults in Lyme, Connecticut. Arthritis Rheum 19:824

    Google Scholar 

  60. Tada I, Sakegnchi Y, Eto K (1979) Dirofilaria in the abdominal cavity of a man in Japan. Am J Trop Med Hyg 28:988–990

    Google Scholar 

  61. Takeuchi T, Asami K, Kobayashi S et al. (1981)Dirofilaria immitis infection in man: report of a case of the infection of the heart and inferior vena cava from Japan. Am J Trop Med Hyg 30:966–969

    Google Scholar 

  62. Tannehill AW, Hatch HB (1968) Coin lesions of the lung toDirofilaria immitis. Dis Chest 53:369–371

    Google Scholar 

  63. Tsung SH, Lin JI, Han D (1982) Pulmonary dirofilariasis in man. Am J Med Sci 283:106–110

    Google Scholar 

  64. Tuazon RA, Firestine F, Blanstein AU (1967) Human pulmonary dirofilariasis manifesting as a coin lesion. A case report. JAMA 199:103–104

    Google Scholar 

  65. Welch JS, Dobson C (1974) The prevalence of antibodies toDirofilaria immitis in Aboriginal and Caucasian Australians. Trans R Soc Trop Med Hyg 68:466–472

    Google Scholar 

  66. Yoshimura H, Ykogawa M (1970) Dirofilaria causing infarct in human lung. Am J Trop Med Hyg 19:63–67

    Google Scholar 

  67. Yoshimura H, Akao N, Kondo K, Ohnishi Y (1980) Human Dirofilariasis in Japan. Case report and review of the literature. Int J Zoon 7:107–114

    Google Scholar 

  68. Zeidler H (1986) Infekt-Ätiologie reaktiver Arthritiden (Abstract) Z Rheumatol 45:174–175

    Google Scholar 

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Langer, H.E., Bialek, R., Mielke, H. et al. Human dirofilariasis with reactive arthritis — Case report and review of the literature. Klin Wochenschr 65, 746–751 (1987). https://doi.org/10.1007/BF01736812

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  • DOI: https://doi.org/10.1007/BF01736812

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