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Aluminum and the pathogenesis of dialysis dementia

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References

  • Alfrey, A.C., LeGendre, G.R. and Kaehny, W.D. 1976. The dialysis encephalopathy syndrome: Possible aluminum intoxication.N. Engl. J. Med.,294, 184–188.

    Google Scholar 

  • Alfrey, A.C., Mischell, J.M., Bruks, J., Contiguglia, S.R., Rudolph, H., Lewin, E. and Holmes, J.H. 1972. Syndrome of dyspraxia and multifocal seizures associated with chronic hemodialysis.Trans. Am. Soc. Artif. Int. Organs,18, 257–261.

    Google Scholar 

  • Altmann, P., Al-Salihi, F., Butter, K., Culler, P. Blair, J. Leeming, R. Cunningham, J. and Marsh, F. 1987 Serum aluminum levels and erythrocyte dihdropteridine reductase activity in patients on hemodialysis.New England J. Med.,317, 80–84

    Google Scholar 

  • Arieff, A.I., Cooper, J.D., Armstrong, D. and Lazarowitz, V.C. 1979. Dementia renal failure and brain aluminum.Annls Int. Med. 90, 741–747.

    Google Scholar 

  • Berkseth, R.O. and Shapiro, F.L. 1980 An epidemic of dialysis encephalopathy and exposure to high aluminum dialysate. In: G.E. Schreiner and J.F. Winchester (eds.),Controversies in Nephrology, vol.II, pp. 42–51. Washington DC; Georgetown University Press.

    Google Scholar 

  • Brun, A. and Dictor, M. 1981. Senile plaques and tangles in dialysis dementia.Acta Path. Microbiol. Scand. 89, 193–198.

    Google Scholar 

  • Cameron, K.R., Birchall, S.M. and Moses, M.A. 1978. Isolation of foamy virus from patient with dialysis encephalopathy.Lancet 2, 796.

    Google Scholar 

  • Cartier, F., Allain, P., Gary, J. Chatel, M. and Peckers, S. 1978. Progressive myoclonic encephalopathy in dialysis patients.Nouv. Presse Med.,7, 97–102

    Google Scholar 

  • Cheung, J.Y., Bonventre, J.V., Malis, C.D. and Leaf A. 1986. Calcium and ischemic injury.New England J. Med. 314, 1670–1676.

    Google Scholar 

  • Cogan, M. Covey, C., Arieff, A.I., Wisniewski, A., Clark, O., Lazarowitz, V.C., Leach, W. 1978. Central nervous system manifestations of hyperparathroidism.Am. J. Med. 65, 963–970.

    Google Scholar 

  • Dewberry, F.L., McKinney T.D. and Stone, W.J. 1980. The dialysis dementia syndrome: report of 14 cases and review of the literature;ASAIO Journal,3, 102–108.

    Google Scholar 

  • Dunea, G. Mahurkar, S.D., Mamdami, B. and Smith, E.C. 1978. Role of aluminum in dialysis dementia.Annls Int Med. 88, 502–504.

    Google Scholar 

  • Francis, P.T., Palmer, A.M., Sims, N.R., Bowen, D.M., Davison, A.N., Esiri, M.M., Neary, D., Snowden J.S. and Wilcock G.K. 1985. Neurochemical studies of early-onset Alzheimer's disease.New England J. Med. 313, 7–11.

    Google Scholar 

  • Fraser, C.L. and Arieff, A.L. 1987. Neurological complications of uremia. In: R.W. Schrier and C.W. Gottschalk (eds.),Strauss and Welt: Diseases of the Kidney, 4th Edition. Little, Brown & Co., Boston, pp. 3063–3092.

    Google Scholar 

  • Fraser, C. Samacki, P. and Arieff A.I. 1985. Calcium transport abnormality in uremic rat brain synaptosomes.J. Clin. Invest. 76, 1789–1795.

    Google Scholar 

  • Friedland P.R., Budinger, T.F., Ganz, E., Yano, Y., Mathis, C.A., Koss, B., Ober, B.A., Huesman, R.H., and Derenzo, S.E. 1983. Regional cerebral metabolic alterations in dementia of the Alzheimer Type: Positron emission tomography with [18F] fluorodeoxyglucose.J. Comp. Ass. Tomography,7, 590–598.

    Google Scholar 

  • Garruto, R.M., Yanagihara, R., Gajdusek, D.C. 1985. Disappearance of high-incidence amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.Neurology 35, 193–198.

    Google Scholar 

  • Garruto, R.M., Swift, C., Yanagihara, R., Fiori, C.E. and Gajdusek, D.C. 1986. Intraneuronal co-localization of silicon with calcium and aluminum in amyotrophic lateral sclerosis and parkinsonism with dementia of Guam.New England J. Med. 315, 711.

    Google Scholar 

  • Garruto, R.M., Fukatsu, R., Yanagihara, R., Gajdusek, D.C., Hook, G. and Fiori, C.E. 1983. Imaging of calcium and aluminum in neurofibrillary tangle-bearing neurons in parkinsonism-dementia of Guam.Proc. Natl Acad. Sci., USA 81, 1875–1879.

    Google Scholar 

  • Guisado R., Arieff, A.I. and Massry, S.G. 1975. Changes in the electroencephalogram in acute uremia.J. Clin. Invest. 55, 738–745.

    Google Scholar 

  • Graf, H., Stummvoll, H.K., Meisinger, V., Kovarik, J., Wolf, A. and Pinggera, W.F. 1981. Aluminum removal by hemodialysis.Kidney Int. 19, 587–591.

    Google Scholar 

  • Hainline, B., Adan, L., Sullivan, J. and Solomon, G. 1986. Increased cerebrospinal fluid aluminum and neurological deterioration following deferoxamine administration in dialysis encephalopathy.Clin. Res. 34, 221 (abstr.).

    Google Scholar 

  • Hershey, C.O., Ricanati, E.S. Hershey, L.A., Vames, A.W., Lavin P.J.M. and Strain, W.H. 1983. Silicon as a potential uremic neurotoxin: Trace element analysis in patients with renal failure.Neurol. 33. 786–798.

    Google Scholar 

  • Kaehny, W.D., Hegg, A.P. and Alfrey, A.C. 1977b. Gastrointestinal absorption of aluminum from aluminum-containing antacids.New England J. Med. 296, 1389–1390.

    Google Scholar 

  • Kaehny, W.D., Alfrey, A.C., Holman, R.E. and Shorr, W.J. 1977a. Aluminum transfer during hemodialysis.Kidney Int. 12, 361–365.

    Google Scholar 

  • Katzman, R. 1976. The prevalence in malignancy of Alzheimer's disease: A major killer.Arch. Gen. Psychiat. 40, 140–143.

    Google Scholar 

  • Katzman, R. 1986. Alzheimer's Disease.New England J. Med.,314, 964–973.

    Google Scholar 

  • Kogeorgos, J. and Scholtz, C. 1982. Neurofibrillary tangles in aluminum encephalopathy: a new finding.Neuropathol. Appl. Neurobiol. 8, 246.

    Google Scholar 

  • Kwentus, J.A., Hart, R., Lingon, N., Taylor, J. and Silverman, J.J. 1986. Alzheimer's Disease.Am. J. Med. 81, 91–96.

    Google Scholar 

  • Luxenberg, J., Feigenbaum, L.Z. and Aron, J.M. 1984. Reversible long- standing dementia with normocalcemic hyperparathyroidism.J. Amer. Geriatrics Soc.,32, 546–547.

    Google Scholar 

  • MacDonald, T.L., Humphreys, W.G. and Martin, R.B. 1987. Promotion of tubulin assembly by aluminum ionin vitro.Science,236. 813–816

    Google Scholar 

  • Mahurkar, S.D., Meyers, L., Cohen, J., Kamath, R.V. and Dunea, G. 1978. Electroencephalograpic and radionucleoitide studies in dialysis dementia.Kidney Intl.,13, 306–315.

    Google Scholar 

  • Mahurkar, S.D., Dhar, S.K., Salta, R., Meyers, L., Smith, E.G. and Dunea, G. 1973. Dialysis dementia.Lancet 1, 1412–1415.

    Google Scholar 

  • Malluche, H.H., Smith, A.J., Abreo, K. and Faugere M.C. 1984. The use of deferoxamine in the management of aluminum accumulation in bone in patients with renal failure.New England J. Med. 311, 140–144.

    Google Scholar 

  • Mathew, R.J., Rabin, P., Stone, W.J. and Wilson, W.H. 1985. Regional cerebral blood flow in dialysis encephalopathy and primary degenerative dementia.Kidney Int. 28, 64–68.

    Google Scholar 

  • McDermott, J.R., Smith, I. and Wisniewski, H.M. 1979. Brain aluminum in aging and Alzheimer disease.Neurol. 29, 809–814.

    Google Scholar 

  • Mayor, G.H., Sprague, S.M., Hourani, M.R. and Sanchez, T.V. 1980. Parathyroid hormone mediated aluminum deposition and egress in the rat.Kidney Intl.,17, 40–44.

    Google Scholar 

  • Mayor, G.H., Keiser, J.A. and Ku, P.K. 1977. Aluminum absorption and distribution: Effect of parathyroid hormone.Science 197, 1187–1189.

    Google Scholar 

  • Mayor, G.H. and Bumatowska-Hiedin, M.A. 1983. Impaired renal function and aluminum metabolism.Fed. Proc. 42, 2979–2984.

    Google Scholar 

  • Nadel, A.M. and Wilson, W.P. 1976. Dialysis encephalopathy: A possible seizure disorder.Neurol. 26, 1130–1134.

    Google Scholar 

  • Nunnelley, L.L., Smythe, W.R., Alfrey, A.C. and Ibels, L.S. 1978. Uremic hyperstannum: elevated tissue tin levels associated with uremia.J. Lab. Clin. Med.,91, 72–75.

    Google Scholar 

  • Olivieri, N.F., Bungig, R.J., Chew, E., Gallant, T., Harrison, R.V., Keenan, N., Logan, W., Mitchell, D., Ricci, G., Skarf, B., Taylor, M. and Freedman, M.H. 1986. Visual and auditory neurotoxicity in patients receiving subcutaneous deferoxamine infusions.New England J. Med.,314, 869–873.

    Google Scholar 

  • Parkinson, I.S., Ward, M.K., Feest, T.G., Fawcett, R.W.P., Kerr, D.N.S. 1979. Fracturing dialysis osteodystrophy and dialysis encephalopathy.Lancet,1, 406–409.

    Google Scholar 

  • Pearce, B.R., Palmer, A.M., Bowen, D.M., Wilcock, G.K., Esiri, M.M. and Davison, A.N. 1984. Neurotransmitter dysfunction and atrophy of the caudate nucleus in Alzheimer's disease.Neurochem. Pathol. 2, 221–232.

    Google Scholar 

  • Perl, D.P., Gajdusek, D.C., Garruto, R.M., Yanagihara, R.T. and Gibbs, C.J. 1982. Intraneuronal aluminum accumulation in amyotrophic lateral sclerosis and parkinsonism-dementia of Guam.Science,217, 1053–1055.

    Google Scholar 

  • Perl, D.P. and Brody, A.R. 1980. Alzheimer's disease: X-ray spectrometric evidence of aluminum accumulation in neurofibrillary tangle-bearing neurons.Science,208, 297–299.

    PubMed  Google Scholar 

  • Perry, T.L., Yong, V.W., Kish, S.J., Foulks, J.G., Godolphin, W.J. and Sweeney, V.P. 1985. Neurochemical abnormalities in brain of renal failure patients treated by repeated hemodialysis.J. Neurochem. 45, 1043–1048.

    Google Scholar 

  • Prior, J.C., Cameron, E.C., Knickerbocker, W.J., Sweeney, V.P. and Suchowersky, O. 1982. Dialysis encephalopathy and osteomalacic bone disease.Am. J. Med.,72, 33–42.

    Google Scholar 

  • Prusiner, S.D. 1984. Some speculations about prions, amyloid, and Alzheimer's disease.New England J. Med. 310, 661–663.

    Google Scholar 

  • Rosenblatt, S. and Faillace, L.A. 1977. Psychiatric manifestations of hyperparathyroidism.Texas Med. 73, 59–60.

    Google Scholar 

  • Rossor, M.N., Iversen, L.L., Reynolds, G.P., Mountjoy, C.Q. and Roth, M. 1984. Neurochemical characteristics of early and late onset types of Alzheimer's disease.Br. Med. J. 288, 961–964.

    Google Scholar 

  • Smythe, W.R., Alfrey, A.C., Craswell, P.W., Crouch, C.A., Ibels, L.S., Kubo, H., Nunnelley, L.L. and Rudolph H. 1982. Trace element abnormalities in chronic uremia.Annls Int. Med. 96, 302–310.

    Google Scholar 

  • Troncosno, J.C., Price, D.L., Griffin, J.W. and Parhad, I.M. 1981. Neurofibrillary axonal pathology in aluminum intoxication.Ann. Neural,12, 278–283.

    Google Scholar 

  • Ward, M.K., Feest, T.G., Ellis, H.A., Parkinson, I.S. and Kerr, D.S. 1978. Osteomalacic dialysis osteodystrophy: evidence for a water-borne etiological agent probably aluminum.Lancet 1, 841–845.

    Google Scholar 

  • Weiss, B. 1978. The behavioral toxicology of metals.Fed. Proc.,37, 22–27.

    Google Scholar 

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  1. Geriatrics Section and Department of Medicine, Veterans Administration Medical Center and University of California School of Medicine, 94121, San Francisco, California, USA

    Allen I. Arieff

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Arieff, A.I. Aluminum and the pathogenesis of dialysis dementia. Environ Geochem Health 12, 89–93 (1990). https://doi.org/10.1007/BF01734056

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