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Structural relatedness ofκ-casein and fibrinogenγ-chain

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Summary

κ-Caseins, involved in the milk clotting process, and human fibrinogenγ-chain, involved in the blood clotting process, show structural similarities. Several longκ-casein sections, together corresponding to 80% of the whole protein molecule, have their counterparts in theγ-chain of fibrinogen, in that 31-42% of the amino acid residues occupy identical positions. The section ofК-casein which contains the chymosin-sensitive bond has a counterpart not only in theγ but also in the Bβ-chain of fibrinogen. Furthermore, the secondary structures of theК-caseins and of theγ-chain predicted according to the method of Chou and Fasman present several common features.

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Authors and Affiliations

  1. Laboratory of Proteins, University of Paris V, 45 rue des Saints-Pères, F-75270, Paris Cedex 06, France

    Pierre Jollès

  2. Institut de Recherches sur le Cancer de Lille, F-59020, Lille Cedex, France

    Marie-Henriette Loucheux-Lefebvre

  3. Max-Planck-Institut für Biochemie, D-8033, Martinsried/München, Federal Republic of Germany

    Agnes Henschen

Authors
  1. Pierre Jollès
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  2. Marie-Henriette Loucheux-Lefebvre
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  3. Agnes Henschen
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41th communication on caseins.

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Jollès, P., Loucheux-Lefebvre, MH. & Henschen, A. Structural relatedness ofκ-casein and fibrinogenγ-chain. J Mol Evol 11, 271–277 (1978). https://doi.org/10.1007/BF01733837

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  • DOI: https://doi.org/10.1007/BF01733837

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