Summary
We have studied the presence of immunoreactive parathyroid hormone (PTH) in the central nervous system and pituitary of sheep. The PTH concentrations were measured radioimmunologically by two different region-specific antibodies. We could demonstrate PTH in various areas of the brain, whole pituitary, parathyroid glands and plasma of 21 sheep. Measurable concentrations of the two different parathyroid regions (35–84 and 44–68 amino acids fragments) were found in all samples.
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Abbreviations
- ACTH:
-
Adrenocorticotrophic hormone
- CT:
-
Calcitonin
- CSF:
-
Cerebrospinal fluid
- CPM:
-
Counts per min
- Leu-ENK:
-
Leucine-enkephalin
- Met-ENK:
-
Methionine-enkephalin
- PTH:
-
Immunoreactive parathyroid hormone
- RIA:
-
Radioimmunoassay
- TSH:
-
Thyroid stimulating hormone
- T4 :
-
Thyroxine
- T3 :
-
Triiodothyronine
References
Arnaud CD, Taso HS, Littledike T (1971) Radioimmunoassay of human parathyroid hormone in serum. J Clin Invest 50:21–34
Balabanova S, Töllner U, Richter HP, Pohlandt F, Gaedicke G, Teller WM (1984) Immunoreactive parathyroid hormone, calcium and magnesium in human cerebrospinal fluid. Acta Endocrinal (Kbh)106:227–233
Becker KL, Snider RH, Moore CF, Monaghan KG, Silva OL (1979) Calcitonin in extrathyroidal tissues of man. Acta Endocrinol (Kbh)92:746–751
Broadwell RD, Brightman MW (1975) Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood. J Comp Neurol 166:257–284
De Rotte AA, Bouman HJ, van Wimersma Greidanus TB (1980) Relationships between alpha-MSH levels in blood and in cerebrospinal fluid. Brain Res 5:375–381
Gerner RH, Sharp B, Catlin DH (1982) Peripherally administeredβ-endorphin increases cerebrospinal fluid endorphin immunoreactivity. J Clin Endocrinol Metabol 55:358–360
Haberman E (1972) Bee and wasp venoms. Science 177:314–322
Hill DE, Schedewie HK, Chalub L, Sziszak TH, Boughter M, Owen J (1978) Evidence for transthecal transfer of insulin in subhuman primates. Clin Res 26:71A
Houghten RA, Swann RW, Li CH (1980)β-Endorphin: stability, clearance behavior, and entry into the central nervous system after intravenous injection of the tritiated peptide in rats and in rabbits. Proc Natl Acad Sci USA 8:4588–4591
Martin R, Geis R, Holl R, Schäfer M, Voigt KH (1983) Co-existence of unrelated peptides in oxytocin and vasopressin terminals of rat neurohypophyses: immunoreactive methionine-enkephalin, leucine-enkephalin- and cholecystokinin-like substances. Neuroscience 8:213–227
Marx SJ, Sharp ME, Krudy A, Rosenblatt M, Mallette L (1981) Radioimmunoassay for the middle region of human parathyroid hormone: studies with a radioiodinated synthetic peptide. J Clin Endocrinol Metab 53:76–84 (1970)
Yamaguchi T, Yamaguchi M, Lajtha A (1970) Inhibition of dipeptide transport in mouse brain slices. J Neurol Sci 10:323–329
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Balabanova, S., King, O., Teller, W.M. et al. Distribution and concentration of immunoreactive parathyroid hormone in brain and pituitary of sheep. Klin Wochenschr 63, 419–422 (1985). https://doi.org/10.1007/BF01733667
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DOI: https://doi.org/10.1007/BF01733667