Summary
In conjunction with a theoretical calculation, a distribution of heterozygosity (more precisely, 2x(1 − x), where x is the allele frequency) was examined with special reference to the neutrality hypothesis of protein polymorphisms. Data of some 400 polymorphic proteins collectively are consistent with the theoretical expectation based on the neutrality hypothesis, although other possibilities are not ruled out.
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This study was supported in part by U.S. Public Health Service Research Grants GM 19513 and GM 20293, and by a Grant-in-Aid from the Ministry of Education, Japan.
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Maruyama, T., Yamazaki, T. Analysis of heterozygosity in regard to the neutrality theory of protein polymorphism. J Mol Evol 4, 195–199 (1974). https://doi.org/10.1007/BF01732024
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DOI: https://doi.org/10.1007/BF01732024