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Hypocalcemia due to osteoblastic metastases and diminished parathyroid reserve in a patient with advanced breast cancer

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Summary

Symptomatic hypocalcemia is an uncommon finding in patients with malignant tumors. A patient with advanced breast cancer is described, who developed severe hypocalcemia in the course of her disease. The hypocalcemia was caused by the combination of enhanced calcium need due to progression of osteoblastic metastases and diminished parathyroid reserve due to tumorous infiltration of the parathyroid glands.

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Abbreviations

1.25 di OH D3 :

1.25 dihydroxy vitamin D3

ECC:

Endogenous creatinine clearance

Hydroxyprol.:

Hydroxyproline

PTH:

Parathyroid hormone

T4:

Thyroxine

TSH:

Thyrotropin-stimulating hormone

References

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Authors and Affiliations

  1. Department of Medicine, Division of Endocrinology, University of Nijmegen, Nijmegen, The Netherlands

    A. Hermus, L. Beex, P. van Liessum, G. Pieters, A. Smals & P. Kloppenborg

  2. Department of Pathology, St. Radboud Hospital, University of Nijmegen, Nijmegen, The Netherlands

    F. Smedts

Authors
  1. A. Hermus
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  2. L. Beex
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  3. P. van Liessum
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  4. G. Pieters
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  5. F. Smedts
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  6. A. Smals
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  7. P. Kloppenborg
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Hermus, A., Beex, L., van Liessum, P. et al. Hypocalcemia due to osteoblastic metastases and diminished parathyroid reserve in a patient with advanced breast cancer. Klin Wochenschr 66, 643–646 (1988). https://doi.org/10.1007/BF01728807

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  • DOI: https://doi.org/10.1007/BF01728807

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