Abstract
Objective
To evaluate the adequacy of visceral oxygen transport and gastric pHi after open heart surgery in patients with stable hemodynamics.
Design
Nonrandomized control trial.
Setting
A general intensive care unit in a tertiary care center.
Patients
Sixteen postoperative cardiac surgery patients were studied after stabilization of systemic hemodynamics.
Interventions
The effect of dobutamine infusion (6 μg kg−1 min−1) on systemic and regional oxygen transport was studied in ten patients, with six patients serving as controls. Systemic oxygen consumption was measured by indirect calorimetry and splanchnic and femoral blood flow, by continuous infusion of indocyanine green using regional catheters and gastric mucosal pHi by gastric tonometer.
Measurements and results
Gastric mucosal acidosis was observed in half of the patients. Dobutamine increased cardiac output (3.2±0.6 vs 4.4±0.7l· min−1·m−2;P<0.05), splanchnic blood flow (0.68±0.28 vs 0.91±0.281· min−1·m−2;p<0.05) and femoral blood flow (0.25±0.08 vs 0.32±0.11l·min−1·m−2;p<0.05). Changes in splanchnic oxygen delivery and consumption were parallel in the two study groups. In response to dobutamine, gastric pHi did not change (7.30±0.08 vs 7.31±0.06; NS), while in the control group, gastric pHi tended to decrease (7.32±0.04 vs 7.28±0.06; NS). Systemic oxygen consumption increased in response to dobutamine (141±11 vs 149±11 ml· min−1·m−2;P<0.05) but did not change in the control group.
Conclusions
We conclude that a mismatch between splanchnic oxygen delivery and demand may be present despite stabilization of systemic hemodynamics after cardiac surgery. This is suggested by the parallel changes in splanchnic oxygen delivery and consumption. Dobutamine is likely to improve splanchnic tissue perfusion at this phase.
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This study was supported in part by the senior researcher's grant no. 1945/3015/92 to Dr. Takala from the Academy of Finland
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Uusaro, A., Ruokonen, E. & Takala, J. Splanchnic oxygen transport after cardiac surgery: evidence for inadequate tissue perfusion after stabilization of hemodynamics. Intensive Care Med 22, 26–33 (1996). https://doi.org/10.1007/BF01728327
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DOI: https://doi.org/10.1007/BF01728327